Professor of Psychiatry
Psychiatry
Dr. John R. Kelsoe, MD
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John R. Kelsoe is an expert in the field of Psychiatry. He attended University of Alabama School of Medicine. University of Alabama School of Medicine is ranked 37 in research and 17 in primary care medicine Doctor John R. Kelsoe, MD is a published physician. He has 94 publications published. The most current publication "Sleep and dreams in Vietnam PTSD and depression."
Publications
- Differential responses to lithium in hyperexcitable neurons from patients with Bipolar disorder.
- Calcium channel genes associated with Bipolar disorder modulate lithium's amplification of circadian rhythms.
- Toward a Valid Animal Model of Bipolar Disorder: How the Research Domain Criteria Help Bridge the Clinical-Basic Science Divide.
- Rare variants in neuronal excitability genes influence risk for Bipolar disorder.
- Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia.
- Genetic pleiotropy between multiple sclerosis and schizophrenia but not Bipolar disorder: differential involvement of immune-related gene loci.
- The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in Bipolar disorder.
- Circadian polymorphisms in night owls, in Bipolars, and in non-24-hour sleep cycles.
- Identification of Pathways for Bipolar Disorder: A Meta-analysis.
- Heritability and linkage analysis of personality in Bipolar disorder.
- Polygenic dissection of diagnosis and clinical dimensions of Bipolar disorder and schizophrenia.
- Heritability and genome-wide SNP linkage analysis of temperament in Bipolar disorder.
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA-B Genotype and Carbamazepine Dosing.
- All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs.
- Improved detection of common variants associated with schizophrenia and Bipolar disorder using pleiotropy-informed conditional false discovery rate.
- Association of dopamine transporter gene variants with childhood ADHD features in Bipolar disorder.
- Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among Bipolar disorder susceptibility variants.
- Genome-Wide Association Study of Irritable vs. Elated Mania Suggests Genetic Differences between Clinical Subtypes of Bipolar Disorder.
- Evidence for association of Bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, ift27 and parvalbumin.
- Genome-wide association study of temperament in Bipolar disorder reveals significant associations with three novel Loci.
- Principles of pharmacogenetics and pharmacogenomics.
- Mitochondrial mutations and polymorphisms in psychiatric Disorders.
- High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia.
- Polymorphisms in melatonin synthesis pathways: possible influences on depression.
- Functional genetic variation in the Rev-Erb? pathway and lithium response in the treatment of Bipolar disorder.
- Genome-Wide Association of Bipolar Disorder Suggests an Enrichment of Replicable Associations in Regions near Genes.
- Delayed sleep phase syndrome is related to seasonal affective Disorder.
- Receptor targets for antidepressant therapy in Bipolar disorder: An overview.
- Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia.
- Suggestive evidence for linkage of ADHD features in Bipolar disorder to chromosome 10p14.
- CRY2 is associated with depression.
- Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in Bipolar disorder.
- Singleton deletions throughout the genome increase risk of Bipolar disorder.
- Transcription factor SP4 is a susceptibility gene for Bipolar disorder.
- Promoter variant in the GRK3 gene associated with Bipolar disorder alters gene expression.
- Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in Bipolar disorder families.
- Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine.
- Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with Bipolar disorder.
- Cosegregation of Bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family.
- Combined analysis from eleven linkage studies of Bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.
- Lack of support for a genetic association of the XBP1 promoter polymorphism with Bipolar disorder in probands of European origin.
- Loci on chromosomes 6q and 6p interact to increase susceptibility to Bipolar affective disorder in the national institute of mental health genetics initiative pedigrees.
- Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene.
- Genomewide linkage analyses of Bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative.
- Genome scan meta-analysis of schizophrenia and Bipolar disorder, part III: Bipolar disorder.
- Some possible genetic parallels across alcoholism, Bipolar disorder and schizophrenia.
- Finding genes for Bipolar disorder in the functional genomics era: from convergent functional genomics to phenomics and back.
- PharmGKB summary: carbamazepine pathway.
- Genomewide association studies: history, rationale, and prospects for psychiatric Disorders.
- Association analysis of GRK3 gene promoter variants in cocaine abuse.
- A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.
- Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals.
- A quantitative neuromotor predictor of antidepressant non-response in patients with Major depression.
- Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion.
- Arguments for the genetic basis of the Bipolar spectrum.
- Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep.
- Functional genomics approaches to understanding brain Disorders.
- A linkage disequilibrium study of Bipolar disorder and microsatellite markers on 22q13.
- Temperament in the clinical differentiation of depressed Bipolar and unipolar major depressive patients.
- Examination of the clock gene Cryptochrome 1 in Bipolar disorder: mutational analysis and absence of evidence for linkage or association.
- TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament.
- A comparison of recovered Bipolar patients, healthy relatives of Bipolar probands, and normal controls using the short TEMPS-A.
- Familiality of temperament in Bipolar disorder: support for a genetic spectrum.
- Genomics and the Human Genome Project: implications for psychiatry.
- New models of collaboration in genome-wide association studies: the Genetic Association Information Network.
- Further evidence for association of GRK3 to Bipolar disorder suggests a second disease mutation.
- Mood-incongruent psychotic features in Bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33.
- The pharmacogenetics of lithium response depends upon clinical co-morbidity.
- Large-scale genome-wide association analysis of Bipolar disorder identifies a new susceptibility locus near ODZ4.
- Familial aggregation of postpartum mood symptoms in Bipolar disorder pedigrees.
- The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.
- Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric Disorders.
- Association study of microsatellite markers on chromosome 22q11-13 with schizophrenia and mood Disorder in Chinese Han population.
- Pharmacogenetics of lithium response in Bipolar disorder.
- Behavioural neuroscience: A gene for impulsivity.
- Genome-wide association analysis of age at onset and psychotic symptoms in Bipolar disorder.
- Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
- Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from Bipolar disorder patients.
- Delayed sleep phase cases and controls.
- Genome-wide parametric linkage analyses of 644 Bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.
- Evidence of association between brain-derived neurotrophic factor gene and Bipolar disorder.
- Circadian polymorphisms associated with affective Disorders.
- Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study.
- Early parental loss and development of adult psychopathology.
- Specific [3H]-N-methyl scopolamine binding without cholinergic function in cultured adult skin fibroblasts.
- Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study.
- Muscarinic receptor density in skin fibroblasts and autopsied brain tissue in affective Disorder.
- Rapid-eye movement sleep and muscarinic receptor binding in rats are augmented during withdrawal from chronic scopolamine treatment.
- Kinetic evidence for decreased methionine adenosyltransferase activity in erythrocytes from schizophrenics.
- Gender differences in outpatient research subjects with affective Disorders: a comparison of descriptive variables.
- Sleep and dreams in Vietnam PTSD and depression.
- Towards the clinical implementation of pharmacogenetics in Bipolar disorder.
- Whole brain expression of Bipolar disorder associated genes: structural and genetic analyses.
Schools
University of Alabama At Birmingham
Washington University
UCSD
Nimh
Conditions Treated
- Bipolar Disorder
- Major Depressive Disorder
Doctors Specialties
- Psychiatry
Accepted Insurances
Education
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National Institutes of Health Clinical Center -
University of California San Diego -
Washington University - Barnes-Jewish Hospital -
University of Alabama School of Medicine
Hospital
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Rady Children's Hospital - San Diego
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