Physician
Pathology
Dr. Jose A. Cancelas, MD
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Jose Cancelas is an expert in the field of Pathology. Jose A. Cancelas, MD is also a published doctor. He has 100 paper published. The most recent paper is: Peripheral blood CD34+ cell immunomagnetic selection in breast cancer patients: effect on hematopoietic progenitor content and hematologic recovery after high-dose che...
Publications
- Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence.
- Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.
- p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche.
- Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial.
- Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network.
- The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collect...
- Additive solution-7 reduces the red blood cell cold storage lesion.
- Overnight, room temperature hold of whole blood followed by 42-day storage of red blood cells in additive solution-7.
- The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.
- Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.
- Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.
- Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.
- Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature.
- In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution.
- p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
- Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated ?1/?2-integrin trafficking.
- Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.
- A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers.
- Lack of communication rusts and ages stem cells.
- Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
- Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.
- A conundrum in mammalian hematopoietic stem cell polarity.
- Stored red blood cell viability is maintained after treatment with a second-generation S-303 pathogen inactivation process.
- Infusion of P-Capt prion-filtered red blood cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation.
- R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.
- In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light-treated whole blood.
- Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.
- Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.
- Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors.
- Cancer stem cells: a stride towards cancer cure?
- Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
- Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
- Rho GTPases in hematopoiesis and hemopathies.
- Rho GTPases in hematopoietic stem cell functions.
- Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus.
- Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.
- FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.
- Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.
- Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.
- Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.
- Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
- Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.
- Rho GTPases and regulation of hematopoietic stem cell localization.
- Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
- Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.
- Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.
- Stem cell collection and gene transfer in Fanconi anemia.
- Children are not little adults: just ask their hematopoietic stem cells.
- Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.
- In vitro and in vivo evaluation of LEUKOSEP HRC-600-C leukoreduction filtration system for red cells.
- The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.
- Stem cell mobilization by beta2-agonists.
- A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.
- Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.
- Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy.
- Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.
- Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.
- Procoagulant activity of T lymphoblastoid cells due to exposure of negatively charged phospholipid.
- Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer.
- Activation of glycogen synthase a in hepatocytes exposed to alpha-D-glucose pentaacetate.
- [Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases].
- Native valve endocarditis due to Candida parapsilosis: a late complication after bone marrow transplantation-related fungemia.
- Effects of oral pentoxifylline on TNF-alpha levels, transplant-related toxicities and engraftment after bone marrow transplantation.
- Immunomagnetic bone marrow purging in children with acute lymphoblastic leukemia.
- Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
- [Pentoxifylline is not useful in the prevention of toxicity associated with bone marrow transplantation].
- Parathyroid hormone-related peptide stimulates DNA synthesis and insulin secretion in pancreatic islets.
- [Hypereosinophilic syndrome induced by GM-CSF in a patient with AIDS. Possible response to alpha-interferon treatment].
- Imprecision of counting CFU-GM colonies and CD34-expressing cells.
- Expansion of cord blood progenitor cells.
- Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patient...
- Expression of phosphatidylinositol anchored membrane proteins in paroxysmal nocturnal haemoglobinuria after bone marrow transplantation.
- Posttransfusion hepatitis after induction chemotherapy in acute nonlymphoblastic leukemia: implications for long-term management and outcome.
- CD34+ cell positive selection from mobilized peripheral blood by an indirect immunomagnetic method: effect of the type of mobilization and assessment of tumor depletio...
- Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells.
- Isolation of CD34+ hematopoietic progenitor cells in chronic myeloid leukemia by magnetic activated cell sorting (MACS).
- Mobilization of peripheral stem cells with intensive chemotherapy (ICE regimen) and G-CSF in chronic myeloid leukemia.
- Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantat...
- Feasibility of ESHAP + G-CSF as peripheral blood hematopoietic progenitor cell mobilisation regimen in resistant and relapsed lymphoma: a single-center study of 22 pat...
- Comparison of volumetric capillary cytometry with standard flow cytometry for routine enumeration of CD34+ cells.
- Myeloablation enhances engraftment of transduced murine hematopoietic cells, but does not influence long-term expression of the transgene.
- Efficient peripheral blood stem cell mobilization with low-dose G-CSF (50 microg/m2) after salvage chemotherapy for lymphoma.
- High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells.
- Effect of glycosylation of recombinant human granulocytic colony-stimulating factor on expansion cultures of umbilical cord blood CD34+ cells.
- Peripheral blood CD34+ cell immunomagnetic selection in breast cancer patients: effect on hematopoietic progenitor content and hematologic recovery after high-dose che...
- Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells.
- Multi-institutional randomized control study of haemolysis in stored red cell units prepared manually or by an automated system.
- On how Rac controls hematopoietic stem cell activity.
- Coagulation factor content of plasma produced from whole blood stored for 24 hours at ambient temperature: results from an international multicenter BEST Collaborative...
- Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.
- Rac guanosine triphosphatases represent a potential target in AML.
- Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and...
- Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells.
- Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
- Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.
- Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
- Rational design and applications of a Rac GTPase-specific small molecule inhibitor.
- Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
- Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an autom...
Doctors Specialties
- Pathology
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