Professor, Vice Chief, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery Director, Head and Neck Cancer Center Moores Cancer Center University of California, San Diego
Otolaryngology (ENT)
Dr. Joseph A. Califano III, MD
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Joseph Califano is an expert in the field of Otolaryngology (ENT). He researched medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He over the years received 9 awards: "CMS Meaningful Use Stage 1 Certification", "Top Doctor", "America's Top Doctors for Cancer", "Baltimore's Top Doctors", "Presidential Citation", "1st place, Basic Science", "1st Place", "Elected Member" and "Fellow (FAAO-HNS)". Joseph Califano is a published physician. He published 100 publications, including: 'Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer.'
Publications
- Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer.
- Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.
- Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma.
- Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients by a Comprehensive Performance Improvement Intervention.
- Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal Cancer.
- Tadalafil augments tumor specific immunity in patients with Head and neck squamous cell carcinoma.
- Sequencing the head and neck Cancer genome: implications for therapy.
- Evaluation of prophylaxis treatment of Candida in alaryngeal patients with tracheoesophageal Voice prostheses.
- Pharyngocutaneous fistula after total laryngectomy: A single-institution experience, 2001-2012.
- Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck Cancer.
- Correcting transcription factor gene sets for copy number and promoter methylation variations.
- Serum biomarkers for detection of Head and neck squamous cell carcinoma.
- Clinical, Genomic and Metagenomic Characterization of Oral Tongue Squamous Cell Carcinoma in Patients Who Do Not Smoke.
- The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell Cancers.
- Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck Cancer.
- Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck Cancer.
- Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma.
- Transcervical ultrasonography is feasible to visualize and evaluate base of tongue Cancers.
- Impact of pharyngeal closure technique on fistula after salvage laryngectomy.
- HPV-related oropharyngeal carcinoma with Overt Level II and/or III metastases at presentation: The risk of subclinical Disease in ipsilateral levels IB, IV and V.
- TransOral Robotic Surgery Experience in 44 Cases.
- Recurrence patterns and management of oral cavity preMalignant lesions.
- Identification of guanine nucleotide-binding protein ?-7 as an epigenetically silenced gene in head and neck Cancer by gene expression profiling.
- DNA copy number variations characterize benign and Malignant thyroid tumors.
- An update regarding objective assessment in residency-based training for transOral robotic surgery.
- The gastrointestinal manifestations of telomere-mediated Disease.
- Suprabasin is hypomethylated and associated with metastasis in Salivary adenoid cystic carcinoma.
- MAGEB2 is Activated by Promoter Demethylation in Head and Neck Squamous Cell Carcinoma.
- Objective assessment in residency-based training for transOral robotic surgery.
- Neck dissection through a facelift incision.
- Dose-Dependent Activation of Putative Oncogene SBSN by BORIS.
- Hyperfractionated Radiotherapy with Concurrent Cisplatin/5-Fluorouracil for Locoregional Advanced Head and Neck Cancer: Analysis of 105 Consecutive Patients.
- Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes.
- Comparison of Promoter Hypermethylation Pattern in Salivary Rinses Collected with and without an Exfoliating Brush from Patients with HNSCC.
- Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck Cancer.
- Tissue imprint for molecular mapping of deep surgical margins in patients with Head and neck squamous cell carcinoma.
- Prescription medication abuse and illegitimate internet-based pharmacies.
- Promoter methylation and loss of p16(INK4a) gene expression in head and neck Cancer.
- Exome sequencing of Head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.
- A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: Creation and rationale for inclusion of tumor (T) characteristics.
- Detection of promoter hypermethylation in salivary rinses as a biomarker for Head and neck squamous cell carcinoma surveillance.
- An epigenetic marker panel for detection of lung Cancer using cell-free serum.
- Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in Malignant melanoma.
- Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma.
- NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in Oral Cavity Squamous Cell Carcinoma tissues and saliva.
- BORIS binding to the promoters of Cancer testis antigens, MAGEA2, MAGEA3 and MAGEA4, is associated with their transcriptional activation in lung Cancer.
- Integrated, genome-wide screening for hypomethylated oncogenes in salivary Gland adenoid cystic carcinoma.
- Enforced Expression of miR-101 inhibits prostate Cancer cell growth by modulating cyclooxygenase-2 pathway in vivo.
- A survey of methylated candidate Tumor suppressor genes in nasopharyngeal carcinoma.
- Conservative management of transnasal intracranial injury.
- The role of MAGEA2 in head and neck Cancer.
- TransOral robotic surgery of the vocal cord.
- Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemOtherapy and radiation therapy for oropharyngeal squamous cell carcinoma.
- Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization.
- Promoter methylation in Head and neck squamous cell carcinoma cell lines is significantly different than methylation in primary tumors and xenografts.
- The value of chest CT in the diagnosis and management of tracheobronchial foreign bodies.
- Promoter hypermethylation in Indian primary Oral squamous cell carcinoma.
- KIF1A and EDNRB are differentially methylated in primary HNSCC and Salivary rinses.
- Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity Cancer and premalignancy.
- Mitochondrial DNA mutation in normal margins and tumors of recurrent Head and neck squamous cell carcinoma patients.
- Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome.
- The epidermal growth factor receptor axis: support for a new target for Oral premalignancy.
- Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission.
- Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of Head and neck squamous cell carcinoma growth in vitro and in vivo.
- Identification of hypermethylated genes associated with cisplatin resistance in human Cancers.
- Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas.
- TKTL1 is activated by promoter hypomethylation and contributes to Head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alp...
- Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes.
- Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary Gland tumors.
- Advances and Perspectives in the Molecular Diagnosis of Head and Neck Cancer.
- The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins.
- Defining the risk of involvement for each Neck nodal level in patients with early T-stage node-positive oropharyngeal carcinoma.
- Novel integrative methods for gene discovery associated with Head and neck squamous cell carcinoma development.
- Severe hypocalcemia complicating thyroid surgery after Roux-en-Y gastric bypass procedure.
- Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in Head and neck s...
- Mitochondrial mutations in adenoid cystic carcinoma of the salivary Glands.
- Integrative discovery of epigenetically derepressed Cancer testis antigens in NSCLC.
- MicroRNA alterations in Head and neck squamous cell carcinoma.
- Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in Cancer cells.
- Cystic lymph node metastasis in patients with head and neck Cancer: An HPV-associated phenomenon.
- ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate Cancer.
- Identification of genes differentially expressed in benign versus Malignant thyroid tumors.
- DCC promoter hypermethylation in esophageal squamous cell carcinoma.
- Methylation of the DFNA5 increases risk of lymph node metastasis in human breast Cancer.
- Vitamin E succinate induces ceramide-mediated apoPtosis in head and neck squamous cell carcinoma in vitro and in vivo.
- Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for Head and neck squamous cell carcinoma.
- TP53 mutations and survival in squamous-cell carcinoma of the Head and neck.
- Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck Cancer.
- A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma.
- DNA global hypomethylation in squamous cell head and neck Cancer associated with smoking, alcohol consumption and stage.
- Mitochondrial mutations are a late event in the progression of head and neck squamous cell Cancer.
- Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell Cancers of the head and neck.
- The role of pre-operative CT-guided FNAB for parapharyngeal space Tumors.
- Supracricoid laryngectomy outcomes: The Johns Hopkins experience.
- Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid Cancer.
- Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces Tumorigenesis and...
- Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/persistent laryngeal Cancer.
- Deleted in colorectal Cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma.
- Estimate of the commercial value of underage drinking and adult abusive and dependent drinking to the alcohol industry.
Schools
Harvard Medical School
Johns Hopkins University School Med
Procedures Preformed
- Antrostomy and Antrotomy (Sinus Surgery)
- Diagnostic Nasal and-or Sinus Endoscopy
- Excision of Facial Bone
- Excision of Parotid, Sublingual, or Submandibular Gland
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Conditions Treated
- Acute Laryngitis
- Acute Tonsillitis
- Allergic Rhinitis
- Bell's Palsy
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Doctors Specialties
- Ear, Nose, and Throat
- Otolaryngology (ENT)
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Top Doctor
- America's Top Doctors for Cancer
- Baltimore's Top Doctors
- Presidential Citation
- 1st place, Basic Science
- 1st Place
- Elected Member
- Fellow (FAAO-HNS)
Education
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Johns Hopkins Carey Business School -
Johns Hopkins University -
Harvard Medical School
Hospital
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UC San Diego Health
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