Professor, Pathology, USC School of Medicine
Pathology
Dr. Joseph A. Dubeau, MD
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Joseph Dubeau works in the field of Pathology. He received awards:"America's Top Doctors", "Top Doctors:LA Area", "America's Top Doctors for Cancer" and "Top Doctors:Southern California". Doctor Joseph A. Dubeau, MD is a published physician. He has 85 publications published. The most current publication "Differences in p16 gene methylation and expression in benign and malignant ovarian tumors."
Publications
- Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.
- Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications.
- Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism.
- Coming into focus: the nonovarian origins of ovarian cancer.
- The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.
- Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs.
- Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent.
- HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer.
- Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
- Pathological characteristics of BRCA-associated breast cancers in Hispanics.
- Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
- 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas.
- BRCA genes: lessons learned from experimental and clinical cancer.
- Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.
- Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.
- HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.
- Hemimethylation footprints of DNA demethylation in cancer.
- Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
- The cell of origin of ovarian epithelial tumours.
- Lymphocyte gene rearrangement studies in formalin-fixed, paraffin-embedded pathology specimens.
- BRCA1-induced ovarian oncogenesis.
- Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.
- Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.
- Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas.
- Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
- The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.
- Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
- Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.
- TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences.
- Intercellular adhesion molecule-1 and childhood asthma.
- A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others.
- Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells.
- Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer.
- Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
- Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy.
- Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone.
- Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells.
- The TATA-binding protein as a regulator of cellular transformation.
- Huntington disease expansion mutations in humans can occur before meiosis is completed.
- Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis.
- Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages.
- p53: a key player in the telomere dynamics.
- Effect of reproductive hormones on ovarian epithelial tumors: II. Effect on angiogenic activity.
- Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity.
- Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth.
- Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children.
- Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children.
- Telomerase and malignant transformation.
- Collection of buccal cell DNA in seventh-grade children using water and a toothbrush.
- Ovarian tumor development: insights from ovarian embryogenesis.
- Conseusus statements on prognostic factors in epithelial ovarian carcinoma. Report of the Consensus Meeting organized by the European Society of Gynaecological Oncolog...
- Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25.
- The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?
- Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential.
- Differences in p16 gene methylation and expression in benign and malignant ovarian tumors.
- Genetics and biology of gynecologic cancer.
- Telomerase and cancer management: silver bullet or fool's gold?
- Detection of ovarian cancer cells: comparison of a telomerase assay and cytologic examination.
- Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases.
- Biology of ovarian cancer.
- Telomerase activity in benign and malignant epithelial ovarian tumors.
- Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis.
- WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.
- Potential role of the inactivated X chromosome in ovarian epithelial tumor development.
- Histologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas.
- Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinobl...
- Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas.
- Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.
- Long-term effects of pulmonary shrapnel injury. Report of a case with carcinoma and residual shrapnel tract.
- The mechanism of replication of phiX174. XVII. Purification and partial characterization of the gene A and A proteins.
- The mechanism of replication of phi X 174. XVIII. Gene A and A* proteins of phi X 174 bind tightly to phi X 174 replicative form DNA.
- A new in vivo model to study invasion and metastasis of human bladder carcinoma.
- Growth of normal and neoplastic urothelium and response to epidermal growth factor in a defined serum-free medium.
- Differential regulation of plasminogen activators by epidermal growth factor in normal and neoplastic human urothelium.
- Studies on immunoglobulin gene rearrangement in formalin-fixed, paraffin-embedded pathology specimens.
- Southern blot analysis of DNA extracted from formalin-fixed pathology specimens.
- Human decidua is a major source of renin.
- Detection of ras point mutations by polymerase chain reaction using mutation-specific, inosine-containing oligonucleotide primers.
- Rapid degradation of extracellular matrix proteins by normal human uroepithelial cells.
- Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas.
- C-myc proto-oncogene amplification detected by polymerase chain reaction in archival human ovarian carcinomas.
- Mechanisms of human bladder tumor invasion: role of protease cathepsin B.
- Culture of human fetal ovarian epithelium in a chemically-defined, serum-free medium: a model for ovarian carcinogenesis.
- Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:LA Area
- America's Top Doctors for Cancer
- Top Doctors:Southern California
Education
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McGill University Faculty of Medicine
Hospital
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Keck Hospital of USC
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