Professor, Psychiatry, Uniformed Services Hebert SOM

Psychiatry

Dr. Juan M. Saavedra, MD

Juan M. Saavedra practices Psychiatry. Juan M. Saavedra is also a published doctor. He has 101 publication published. The most recent publication is: Melatonin receptors mediate contraction of a rat cerebral artery. Dr. Juan M. Saavedra accepts all Medicare patients.

Publications

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKÎ²-dependent AMPK activation.
Neurorestoration after traumatic brain injury through angiotensin II receptor blockage.
Neuroprotective Effects of Angiotensin Receptor Blockers.
Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARÎ³ activation.
Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders.
Angiotensin II AT(1) receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restr...
Angiotensin II AT(1) Receptor Blockers Ameliorate Inflammatory Stress: A Beneficial Effect for the Treatment of Brain Disorders.
Angiotensin II AT(1) receptor blockade ameliorates brain inflammation.
In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland.
Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery.
In Memoriam: John William Daly (1933-2008).
Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen.
Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivo.
Angiotensin II AT1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal gland.
The challenge of genetic studies in hypertension.
Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain.
The discovery of a novel macrophage binding site.
A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.
Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats.
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats.
Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, an...
Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress.
Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain.
Molecular cloning, characterization, and distribution of the gerbil angiotensin II AT2 receptor.
Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury.
Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription.
Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inh...
Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene.
The future of Latin American science.
Estrogen upregulates renal angiotensin II AT(2) receptors.
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist.
Site-directed mutagenesis of the gerbil and human angiotensin II AT(1) receptors identifies amino acid residues attributable to the binding affinity for the nonpeptidi...
Pineal muscarinic phosphoinositide responses: age-associated sensitization, agonist-induced desensitization and increase in melatonin release from cultured pineal glands.
Differential development of insulin-like growth factor I binding in the suprachiasmatic nucleus and median eminence of the rat hypothalamus.
Differential development of insulin-like growth factor-I binding in the hypothalamus of hamster and rat.
Differential sensitivity to cations of the melatonin receptors in the rat area postrema and suprachiasmatic nuclei.
The chick retinal melatonin receptor revisited: localization and modulation of agonist binding with guanine nucleotides.
Melatonin receptors mediate contraction of a rat cerebral artery.
Vascular melatonin receptors.
Characterization of melatonin receptors in the rat area postrema: modulation of affinity with cations and guanine nucleotides.
Localization of neuropeptide Y binding sites in the zona glomerulosa of the bovine adrenal gland.
Autoradiographic studies of 5HT2 receptors.
Angiotensin-converting enzyme in discrete areas of the rat forebrain and pituitary gland.
Brain TRH, monoamines, tyrosine hydoxylase, and tryptophan hydroxylase in the woodchuck, Maromota monax, during the hibernation season.
Somatostatin inhibits the isoproterenol-stimulated adenylate cyclase in the intermediate lobe of the male rat pituitary gland.
Early increase in adrenomedullary catecholamine synthesis in sinoaortic denervated rats.
Quantitative autoradiographic determination of angiotensin-converting enzyme (kininase II) binding in individual rat brain nuclei with 125I-351A, a specific enzyme inh...
Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in discrete areas of the rat limbic system.
Increased brain stem and decreased hypothalamic adrenaline-forming enzyme after acute and repeated immobilization stress in the rat.
Common receptors for hallucinogens in rat brain: a comparative autoradiographic study using [125I]LSD and [125I]DOI, a new psychotomimetic radioligand.
Cholinergic stimulation of phosphoinositide hydrolysis in the rat pineal gland.
Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number.
Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in the individual rat hypothalamic nuclei.
Lack of vasopressin increases hypothalamic atrial natriuretic peptide binding sites.
Quantitative autoradiography of beta-adrenoceptors in the cardiac vagus ganglia of the rat.
Opportunities and limitations of genetic analysis of hypertensive rat strains.
Autoradiography of LSD and 2,5-dimethoxyphenylisopropylamine psychotomimetics demonstrates regional, specific cross-displacement in the rat brain.
Localization and characterization of atrial natriuretic peptide binding sites in discrete areas of rat brain and pituitary gland by quantitative autoradiography.
Letter: Sympathoadrenal medullary activity in young, spontaneously hypertensive rats.
Brain catecholamines during development of DOCA-salt hypertension in rats.
Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats.
Fastigial stimulation in rats releases adrenomedullary catecholamines.
Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat.
Correlations of smoothness index and trough-to-peak ratio with left ventricular mass index changes induced by lercanidipine in hypertensive patients. A pilot trial.
Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists.
Estrogen-induced efflux of endogenous catecholamines from the hypothalamus in vitro.
Angiotensin II AT1 receptor antagonism downregulates stress-related gene expression in brain microvessels from spontaneously hypertensive and normotensive rats.
Changes in dopamine, noradrenaline and adrenaline in specific septal and preoptic nuclei after acute immobilization stress.
Angiotensin II AT1 and AT2 receptor types regulate basal and stress-induced adrenomedullary catecholamine production through transcriptional regulation of tyrosine hyd...
Dietary sodium and renal alpha 2-adrenergic receptors in Dahl hypertensive rats.
The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression.
Association between increased serotonin metabolism in rat brainstem nuclei and development of spontaneous hypertension.
Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted mice.
Effects of catecholamines, adrenergic substances and their blocking agents on the searching behavior of mice.
Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats.
Adrenaline, noradrenaline and dopamine levels in specific brain stem areas of acutely immobilized rats.
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice.
High-protein carboxymethylase activity and low endogenous methyl acceptor proteins in posterior pituitary lobe of rats lacking neurophysin-vasopressin (Brattleboro rats).
Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress.
Effect of surgical isolation of the hypothalamus on its neurotransmitter content.
Angiotensin and cerebral blood flow.
Estradiol increases dopamine turnover in intermediate and posterior pituitary lobes of ovariectomized rats.
Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319.
Coexistence of several putative neurotransmitters in single identified neurons of Aplysia.
Nonpeptide angiotensin AT1 and AT2 receptor ligands modulate the upper limit of cerebral blood flow autoregulation in rats.
Octopamine: presence in single neurons of Aplysia suggests neurotransmitter function.
[125I]CGP 42112 reveals a non-angiotensin II binding site in 1-methyl-4-phenylpyridine (MPP+)-induced brain injury.
Biogenic amines and related enzymes in the circumventricular organs of the rat.
Angiotensin-II receptor subtypes in median eminence and basal forebrain areas involved in regulation of pituitary function.
Catecholamines in the raphe nuclei of the rat.
Differential development of angiotensin II receptor subtypes in the rat brain.
Control of pineal N-acetylserotonin by a beta adrenergic receptor.
Brain angiotensin II, an important stress hormone: regulatory sites and therapeutic opportunities.
Central and peripheral catecholamine innervation of the rat intermediate and posterior pituitary lobes.
Reproductive hormones modulate angiotensin II AT1 receptors in the dorsomedial arcuate nucleus of the female rat.
Changes in epinephrine in individual hypothalamic nuclei after immobilization stress.
Characterization of AT2 receptor expression in NIH 3T3 fibroblasts.
Biochemical and histochemical studies of biogenic amines in spinal cord trauma.

Procedures Preformed

Psychiatric Evaluation

Conditions Treated

Schizophrenia

Doctors Specialties

Psychiatry

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