Professor, Internal Medicine, University of Michigan Medical School
Gastroenterology
Dr. Juanita L. Merchant, MD
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Dr. Juanita L. Merchant is an expert in the field of Gastroenterology. She attended Yale University School of Medicine. Yale University School of Medicine is a top medical university. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care She over the years received 3 awards: "CMS Meaningful Use Stage 1 Certification", "Elected Member" and "Investigator Alumnus". Juanita L. Merchant is a published physician. She has 101 papers published. The most current publication "Sp1 phosphorylation by Erk 2 stimulates DNA binding." Juanita Merchant accepts Medicare payments and is registered with Medicare.gov.
Publications
- Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.
- Increased Expression of DUOX2 is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.
- Stress Hematopoiesis Is Regulated by the Krüppel-Like Transcription Factor ZBP-89.
- Identification of a Functional TPH1 Polymorphism Associated With Irritable Bowel Syndrome Bowel Habit Subtypes.
- Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
- Inhibition of Hedgehog signaling in the gastroIntestinal tract: Targeting the cancer microenvironment.
- Dual Oxidases Control Release of Hydrogen Peroxide by the Gastric Epithelium to Prevent Helicobacter felis Infection and Inflammation in Mice.
- Gli1 deletion prevents helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
- ZBP-89 Regulates Expression of Tryptophan Hydroxylase I and Mucosal Defense Against Salmonella Typhimurium in Mice.
- Butyrate increases IL-23 production by stimulated dendritic cells.
- Plasma Shh levels reduced in pancreatic cancer patients.
- Transgenic Expression of Interferon-γ in Mouse Stomach Leads to Inflammation, Metaplasia, and Dysplasia.
- A high-fat diet regulates gastrin and acid secretion through primary cilia.
- Conditional Deletion of Menin Results in Antral G Cell Hyperplasia and Hypergastrinemia.
- IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice.
- Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma.
- Hedgehog Signaling in Gut Development, Physiology, and Cancer.
- Menin and JunD regulate gastrin gene expression through proximal DNA elements.
- Gastric tuft cells express DCLK1 and are expanded in hyperplasia.
- Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion.
- Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice.
- Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements.
- Hedgehog is an anti-inflammatory epithelial signal for the Intestinal lamina propria.
- Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog.
- Underrepresentation of underrepresented minorities in academic medicine: the need to enhance the pipeline and the pipe.
- Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastroIntestinal patterning.
- Induction of follistatin precedes gastric transformation in gastrin deficient mice.
- Somatostatin stimulates menin gene expression by inhibiting protein kinase A.
- Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice.
- What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis.
- Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89.
- Prospective identification of a multilineage progenitor in murine stomach epithelium.
- Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation.
- Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete Intestinal metaplasia.
- ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate.
- Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and Disease.
- Inhibition of growth hormone receptor gene expression by saturated fatty acids: role of Kruppel-like zinc finger factor, ZBP-89.
- Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia.
- Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
- Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense.
- Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.
- Intestinal alkaline phosphatase gene expression is activated by ZBP-89.
- Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function.
- Inflammation, atrophy, gastric cancer: connecting the molecular dots.
- Interferon gamma induction of gastric mucous neck cell hypertrophy.
- Helicobacter pylori cag-type IV secretion System facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils.
- Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells.
- Evidence that Loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer.
- Helicobacter-induced Intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin.
- The Epstein-Barr virus protein BMRF1 activates gastrin transcription.
- Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment.
- Inflammation and cancer III. Somatostatin and the innate immune System.
- Treatment of Helicobacter gastritis with IL-4 requires somatostatin.
- ZBP-89 mediates butyrate regulation of gene expression.
- Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89.
- A model for integrative study of human gastric acid secretion.
- Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer.
- Hypergastrinemia in response to gastric inflammation suppresses somatostatin.
- Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice.
- Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis.
- ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells.
- Hedgehog signaling in gastric physiology and cancer.
- Hedgehog signaling and gastroIntestinal cancer.
- Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe?
- ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
- Regulated expression of the human gastrin gene in mice.
- A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion.
- H pylori infection causes chronic Pancreatitis in Mongolian gerbils.
- P53 mutants suppress ZBP-89 function.
- An isoform of ZBP-89 predisposes the colon to Colitis.
- Identification of zinc finger binding protein 89 (ZBP-89) as a transcriptional activator for a major bovine growth hormone receptor promoter.
- Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori.
- Epithelial cell turnover in relation to ongoing damage of the gastric mucosa in patients with early gastric cancer: increase of cell proliferation in paramalignant les...
- Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma.
- Modulating the cytokine response to treat Helicobacter gastritis.
- Transcription factor ZBP-89 is required for STAT1 constitutive expression.
- Acinetobacter lwoffii infection and gastritis.
- ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells.
- Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells.
- Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer.
- The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.
- ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression.
- TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms.
- The zinc finger repressor, ZBP-89, binds to the silencer element of the human vimentin gene and complexes with the transcriptional activator, Sp1.
- Epidermal growth factor stimulation of the human gastrin promoter requires Sp1.
- Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis.
- ZBP-89, a Krüppel-type zinc finger protein, inhibits cell proliferation.
- EGF stimulates gastrin promoter through activation of Sp1 kinase activity.
- cAMP regulates gastrin gene expression.
- Use of flow cytometry to quantify mouse gastric epithelial cell populations.
- Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activit...
- Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice.
- ZBP-89-induced apoptosis is p53-independent and requires JNK.
- ZBP-89 promotes growth arrest through stabilization of p53.
- Sp1 phosphorylation by Erk 2 stimulates DNA binding.
- Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter.
- Sp1 affinity for GC-rich elements correlates with ornithine decarboxylase promoter activity.
- EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures.
- Identification of a cis-regulatory element mediating somatostatin inhibition of epidermal growth factor-stimulated gastrin gene transcription.
- ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.
Schools
Yale University
Massachusetts General Hospital
University Of California Los Angeles
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Benign Neoplasm of the Digestive System
- Cholecystitis and Gallstones
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Investigator Alumnus
Education
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Massachusetts General Hospital -
Yale University School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1164505095 |
| Last Name Of The Provider | MERCHANT |
| First Name Of The Provider | JUANITA |
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