Physician
Internal Medicine
Dr. Kathleen A. Collins, MD
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Kathleen A. Collins practices Internal Medicine. She went to medical school at University of California San Diego School of Medicine. University of California San Diego School of Medicine is ranked 17 in research and 19 in primary care medicine She received 1 awards: "CMS Meaningful Use Stage 1 Certification". Doctor Kathleen A. Collins, MD is a published doctor as well. She has 64 publications published. The latest was: HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
Publications
- Control of telomerase action at human telomeres.
- The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
- Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
- Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.
- Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.
- HIV-1 accessory proteins adapt cellular adaptors to facilitate immune evasion.
- Tetrahymena Telomerase Holoenzyme Assembly, Activation, and Inhibition by Domains of the p50 Central Hub.
- Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.
- The architecture of Tetrahymena telomerase holoenzyme.
- tRNA Binding, Structure, and Localization of the Human Interferon-Induced Protein IFIT5.
- Initiation by a eukaryotic RNA-dependent RNA polymerase requires looping of the template end and is influenced by the template-tailing activity of an associated uridyl...
- High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase.
- Subnuclear shuttling of human telomerase induced by transformation and DNA damage.
- Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote.
- A single RNA-dependent RNA polymerase assembles with mutually exclusive nucleotidyl transferase subunits to direct different pathways of small RNA biogenesis.
- Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.
- Roles for RNA in telomerase nucleotide and repeat addition processivity.
- Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function.
- A novel RNA binding domain in tetrahymena telomerase p65 initiates hierarchical assembly of telomerase holoenzyme.
- The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation.
- Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation.
- Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.
- Reconstitution of simian virus 40 DNA replication with purified proteins.
- Initiation of SV40 DNA replication: mechanism and control.
- Naturally attenuated HIV--lessons for AIDS vaccines and treatment.
- Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme.
- Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.
- An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance.
- Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA.
- Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
- Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase.
- Transcriptional regulation of the human prointerleukin 1 beta gene.
- The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.
- HIV''s evasion of the cellular immune response.
- HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
- HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.
- HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.
- Hematopoietic stem/precursor cells as HIV reservoirs.
- Down-modulation of CD8?? is a fundamental activity of primate lentiviral Nef proteins.
- ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking i...
- The emerging role of HLA-C in HIV-1 infection.
- The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells.
- HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
- HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.
- Towards a cure for HIV: the identification and characterization of HIV reservoirs in optimally treated people.
- Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells.
- HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.
- Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.
- This bud's for Vpu.
- HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.
- A novel trafficking signal within the HLA-C cytoplasmic tail allows regulated expression upon differentiation of macrophages.
- The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmi...
- HLA-B44 polymorphisms at position 116 of the heavy chain influence TAP complex binding via an effect on peptide occupancy.
- Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.
- HIV-1 Nef disrupts antigen presentation early in the secretory pathway.
- Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation ...
- HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.
- Resistance of HIV-infected cells to cytotoxic T lymphocytes.
- How HIV evades CTL recognition.
- Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
- Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.
- Species-specific effects of HIV-1 Nef-mediated MHC-I downmodulation.
- Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking.
Schools
David Geffen School Of Medicine At UCLA University Of California Los Angeles
Kaiser Permanente Med Center Sf
Pacific Presby Med Center
Procedures Preformed
- Cardiac Imaging
- Cardiac Myocardial Perfusion Imaging
- Chest CT (incl. Heart and Lungs)
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
- View All
Doctors Specialties
- Cardiology
- Internal Medicine
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Kaiser Foundation Hospital -
University of California San Diego School of Medicine
Hospital
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Carle Foundation Hospital -
Presence Covenant Medical Center
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