Professor of Obstetrics and Gynecology, Washington University St Louis

Obstetrics & Gynecology

Kelle Moley practices Obstetrics & Gynecology. She attended Yale University School of Medicine. Yale University School of Medicine is a one of the best medicals schools. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care She over the years received 2 awards: "Regional Top Doctor" and "Elected Member". Kelle Moley is also published. She has 101 publications published. The lastest publication: "HCFA links Medicare's future with capitation. Interview by Janet Firshein.'

Publications

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• The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.
• Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in Mice.
• Maternal Obesity, Cage Density, and Age Contribute to Prostate Hyperplasia in Mice.
• Metabolic Determinants of Mitochondrial Function in Oocytes.
• Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd(ts)] is mediated through crosstalk between Ahr-Nrf2 pathway and MAPK signaling.
• Obesity and PCOS: The Effect of Metabolic Derangements on Endometrial Receptivity at the Time of Implantation.
• TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin.
• Modeling the Effect of Cigarette Smoke on Hexose Utilization in Spermatocytes.
• Glucose Transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
• Modulation of cell cycle progression in the spermatocyte cell line [GC-2spd(ts) Cell-Line] by cigarette smoke condensate (CSC) via arylhydrocarbon receptor-nuclear fac...
• The aryl hydrocarbon receptor is important for proper seminiferous tubule architecture and sperm development in mice.
• Glucose Transporter-8 (GLUT8) Mediates Glucose Intolerance and Dyslipidemia in High-Fructose Diet-Fed Male Mice.
• DHEA-mediated inhibition of the pentose phosphate pathway alters oocyte lipid metabolism in mice.
• False-positive results in home ovulation prediction devices due to very low concentrations of human chorionic gonadotropin.
• Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems.
• The apical sorting signal for human GLUT9b resides in the N-terminus.
• Molecular Analysis of Cell Type-Specific Gene Expression Profile During Mouse Spermatogenesis by Laser Microdissection and qRT-PCR.
• Decreased Spermatogenesis, Fertility, and Altered Slc2A Expression in Akt1-/- and Akt2-/- Testes and Sperm.
• Smaller fetal size in singletons after infertility therapies: the influence of technology and the underlying infertility.
• Elevated serum α-linolenic acid levels are Associated with decreased chance of pregnancy after in vitro fertilization.
• Sex Steroid Hormones and Reproductive Disorders: Impact on Women's Health.
• Dehydroepiandrosterone Inhibits Glucose Flux Through the Pentose Phosphate Pathway in Human and Mouse Endometrial Stromal Cells, Preventing Decidualization and Implant...
• Preimplantation Exposure of Mouse Embryos to Palmitic Acid Results in Fetal Growth Restriction Followed by Catch-Up Growth in the Offspring.
• Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles.
• The impact of obesity on egg quality.
• Associations between free fatty acids, cumulus oocyte complex morphology and Ovarian function during in vitro fertilization.
• Improved Insulin Sensitivity by GLUT12 Overexpression in Mice.
• Quantitative Analysis of Glucose Transporter mRNAs in Endometrial Stromal Cells Reveals Critical Role of GLUT1 in Uterine Receptivity.
• Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles.
• Asymmetric syncytial expression of GLUT9 splice variants in human term placenta and alterations in diabetic Pregnancies.
• Automated microinjection of recombinant BCL-X into mouse zygotes enhances embryo development.
• Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research.
• Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.
• Diet-induced obesity model: abnormal oocytes and persistent growth Abnormalities in the offspring.
• Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice.
• Glucose transporters in gametes and preimplantation embryos.
• Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells.
• Follicular origins of modern reproductive endocrinology.
• Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes.
• Facilitative glucose transporter 9, a unique hexose and urate transporter.
• Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium.
• Morbid obesity is Associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome.
• Facilitative glucose transporter 9 (GLUT9), a unique hexose and urate transporter.
• Facilitative glucose transporter type 1 is differentially regulated by progesterone and estrogen in murine and human endometrial stromal cells.
• Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model.
• SLC2A9 is a high-capacity urate transporter in humans.
• Role of glucose in cloned mouse embryo development.
• Encouraging patient-driven single-embryo transfer.
• The facilitative glucose transporter GLUT3: 20 years of distinction.
• Maternal tobacco use and its preimplantation effects on fertility: more reasons to stop smoking.
• The impact of type 1 and type 2 diabetes mellitus on the oocyte and the preimplantation embryo.
• Epigenetics and assisted reproductive technologies: human imprinting Syndromes.
• Oocyte and preimplantation embryo perturbations: long-term effects on offspring. Preface.
• One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring.
• Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.
• AMP kinase activation increases glucose uptake, decreases apoptosis, and improves Pregnancy outcome in embryos exposed to high IGF-I concentrations.
• Disordered meiotic regulation of oocytes by duration of diabetes mellitus in BBdp rat.
• The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm.
• A randomized, prospective study comparing laser-assisted hatching and assisted hatching using acidified medium.
• AMPK regulation of mouse oocyte meiotic resumption in vitro.
• Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts.
• Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes.
• Radiologic and surgical demonstration of uterine polyposis.
• Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies.
• The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo.
• Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.
• Factors Associated with preterm delivery in mothers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS registry.
• Association between BeckWith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients.
• TRAIL and KILLER are expressed and induce apoptosis in the murine preimplantation embryo.
• Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.
• Septate uterus With cervical duplication and longitudinal vaginal septum: a report of five new cases.
• GLUT9 is differentially expressed and targeted in the preimplantation embryo.
• Syntaxin 4 expression affects glucose transporter 8 translocation and embryo survival.
• Studies With GIP/Ins cells indicate secretion by gut K cells is KATP channel independent.
• Immunohistologic staining of muscle and embryos to detect insulin-stimulated translocation of glucose transporters.
• Single-embryo measurement of basal- and insulin-stimulated glucose uptake.
• Metabolic changes in the glucose-induced apoptotic blastocyst suggest alterations in mitochondrial physiology.
• Glucose transporter 8 expression and translocation are critical for murine blastocyst survival.
• Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
• Preimplantation exposure to high insulin-like growth factor I concentrations results in increased resorption rates in vivo.
• Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage.
• Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus.
• The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.
• Glucose transporter isoform-3 mutations cause early Pregnancy loss and fetal growth restriction.
• Utilization of DR1 as true RARE in regulating the Ssm, a novel retinoic acid-target gene in the mouse testis.
• A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity.
• Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth f...
• Somatic cell-like features of cloned mouse embryos prepared With cultured myoblast nuclei.
• Male mice that do not express group VIA phospholipase A2 produce spermatozoa With impaired motility and have greatly reduced fertility.
• Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy.
• HCFA links Medicare's future With capitation. Interview by Janet Firshein.
• Dose-response effects of glucose, insulin, and glucagon on mouse pre-embryo development.
• Polony analysis of gene expression in ES cells and blastocysts.
• Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.
• Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte.
• Glucosamine inhibits decidualization of human endometrial stromal cells and decreases litter sizes in mice.
• The Fatty Acid Beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice.
• Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.
• Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity.
• GATA4 regulates Sertoli cell function and fertility in adult male mice.

Schools

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• Yale University

• Barnes Jewish Hospital S Campus

Procedures Preformed

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• Fluid Contrast Ultrasound
• Hysteroscopy

Conditions Treated

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• Encounters for High-Risk Pregnancies
• Endometriosis
• Hematologic Abnormalities Associated With Pregnancy
• Menstrual Disorders (incl. Dysmenorrhea)
• View All

Doctors Specialties

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• Obstetrics
• Gynecology

Accepted Insurances

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Awards

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• Regional Top Doctor
• Elected Member

Education

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• Washington University - Barnes-Jewish Hospital
• Yale University School of Medicine

Hospital

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• Barnes-Jewish Hospital
• St. Louis Children's Hospital

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