Professor, Pediatric Hematology and Oncology, Baylor College of Medicine
Pediatric Hematology & Oncology
Dr. Kenneth McClain, MD
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Kenneth McClain is an expert in the field of Pediatric Hematology & Oncology. He graduated from University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine He over the years received 1 awards: "Super Doctor". Kenneth McClain, MD is a published doctor and has 100 publications published. The lastest was: 'Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma.'
Publications
- Treatment of Langerhans cell histiocytosis: it is time to learn from the past: response to Minkov and Rodriguez-Galindo.
- Up-front therapy for LCH: is it time to test an alternative to vinblastine/prednisone?
- Differentiating skin-limited and multisystem langerhans cell histiocytosis.
- Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
- Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.
- BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
- Pediatric Burkitt's Lymphoma and Diffuse B-Cell Lymphoma: Are Surveillance Scans Required?
- Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai-Dorfman Disease.
- Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.
- Human herpesvirus 6 and cytomegalovirus infections in children with human immunodeficiency virus infection and cancer.
- Need for a cooperative study: Pulmonary Langerhans cell histiocytosis and its management in adults.
- Molecular analysis and pathology of a second pediatric HIV-associated Burkitt Lymphoma.
- Hemophagocytic syndrome in children: an important diagnostic consideration in fever of unknown origin.
- Hemophagocytic lymphohistiocytosis masquerading as child abuse: presentation of three cases and review of central nervous system findings in hemophagocytic lymphohisti...
- Risk factors for pediatric human immunodeficiency virus-related malignancy.
- Hemophagocytic syndrome after Kawasaki Disease.
- Adult Langerhans cell histiocytosis limited to the skin.
- Langerhans cell histiocytosis patients have HLA Cw7 and DR4 types associated with specific clinical presentations and no increased frequency in polymorphisms of the tu...
- Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group.
- Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis.
- Anti-CD52 antibody, alemtuzumab, binds to Langerhans cells in Langerhans cell histiocytosis.
- Atypical cellular Disorders.
- Drug therapy for the treatment of Langerhans cell histiocytosis.
- Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine.
- A phase II trial using thalidomide for Langerhans cell histiocytosis.
- Precursor B-cell Acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis.
- EBV+ lymphoproliferative Disease following prolonged chemotherapy for refractory LCH.
- Langerhans cell histiocytosis: a review of past, current and future therapies.
- In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis.
- Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis.
- Disparity in the management of iron overload between patients with sickle cell Disease and thalassemia who received transfusions.
- Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis.
- Diabetes insipidus in Langerhans cell histiocytosis: When is treatment indicated?
- Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions.
- Hemophagocytic lymphohistiocytosis in a patient with x-linked lymphoproliferative Disease.
- Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine/cytosine arabinoside.
- Hemophagocytic lymphohistiocytosis in Texas: observations on ethnicity and race.
- Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman Disease.
- Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells.
- Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality.
- Erdheim-Chester: beyond the lesion.
- Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions.
- How we treat hemophagocytic lymphohistocytosis.
- Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis.
- Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis.
- Aseptic meningitis in a child after systemic treatment with high dose cytarabine.
- DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in Langerhans cell histiocytosis (LCH).
- Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell Lymphoma in a child with AIDS.
- Evaluation of human herpesvirus type 8 infection in childhood langerhans cell histiocytosis.
- Acquired immune deficiency, myelodysplasia, and Acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocyt...
- HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
- Increased blood Myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis.
- Cancers in children with HIV infection.
- Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma.
- Langerhans cell histiocytosis: lack of a viral etiology.
- Reactivations in multisystem Langerhans cell histiocytosis: data of the international LCH registry.
- Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society.
- The spectrum of mucosa-associated lymphoid tissue lesions in pediatric patients infected with HIV: A clinicopathologic study of six cases.
- Tumors of smooth-muscle origin in HIV-infected children.
- Viruses and Langerhans cell histiocytosis: is there a link?
- A familial lymphoproliferative disorder presenting with primary pulmonary manifestations.
- Persistence of self-renewing leukemia cell progenitors during remission in children with B-precursor Acute lymphoblastic leukemia.
- Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection.
- Hemophagocytic lymphohistiocytosis associated with precursor B Acute lymphoblastic leukemia.
- B19 parvovirus-induced Anemia in a normal child. Initial bone marrow erythroid hyperplasia and response to intravenous immunoglobulin.
- Hodgkin's Disease associated with central pontine myelinolysis.
- Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B Acute lymphoblastic leukemia.
- Virus-associated histiocytic proliferations in children. Frequent association with Epstein-Barr virus and congenital or acquired immunodeficiencies.
- Recurrent human parvovirus B19-induced Anemia: initial manifestation of humoral immunodeficiency.
- Histiocytic Disorders: recent insights into pathophysiology and practical guidelines.
- Epstein-Barr virus--determined clonality in posttransplant lymphoproliferative Disease.
- Measurement of residual leukemia during remission in childhood Acute lymphoblastic leukemia.
- Respiratory contamination of polymerase chain reactions by human herpesvirus 6.
- The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome?
- Heterogeneity in lineage derivation of Philadelphia-positive Acute lymphoblastic leukemia expressing p190BCR-ABL or p210BCR-ABL: determination by analysis of individua...
- Infection-associated hemophagocytic syndrome. Evidence for Epstein-Barr virus gene expression.
- Immunotherapy of melanoma: a dichotomy in the requirement for IFN-gamma in vaccine-induced antitumor immunity versus adoptive immunotherapy.
- Epstein-Barr virus associated B cell lymphoproliferative Disorders following bone marrow transplantation.
- Using granulocyte colony-stimulating factor for Neutropenia during neonatal sepsis.
- Primary leptomeningeal B-cell Lymphoma in a 8-year-old child.
- Molecular and virologic characteristics of lymphoid malignancies in children with AIDS.
- Epstein-Barr virus and HIV-AIDS-associated Diseases.
- Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin Disease.
- Prolongation of the prothrombin time after organophosphate poisoning.
- Congenital parvovirus infection.
- Role of staging bone marrow examination in children with Hodgkin Disease.
- Adenovirus and childhood immune thrombocytopenic purpura.
- Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS.
- B-cell lymphoproliferative Disorders in children after bone marrow transplantation: radiologic manifestations.
- Chronic neutropenia of childhood: frequent association with parvovirus infection and correlations with bone marrow culture studies.
- Bone marrow involvement in histiocytosis X.
- Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS.
- Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative Disease.
- Immunodeficiency states and related malignancies.
- Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: a Pediatric Oncology Group study.
- The role of tranexamic acid in the treatment of giant hemangiomas in newborns.
- Epstein-Barr-virus-related post-bone-marrow-transplant lymphoproliferative Disease: association with cytomegalovirus infection and Down syndrome donor marrow.
- Small noncleaved B cell Burkitt-like Lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired...
- Incidence of childhood and adolescent cancer in Texas.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Johns Hopkins Hospital
National Institute HlthNichd
University Of Minnesota
Conditions Treated
- Acute Leukemia
- Anemia
- Chronic Myeloid Leukemia (CML)
- Deep Vein Thrombosis (DVT)
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
- Aetna
- Amerigroup (Wellpoint)
- Assurant Health
- Blue Card PPO
- Blue Choice
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- Emblem Health
- Health Alliance
- Choice Care PPO
- Preferred PPO
- Medicaid
- Medicare MCR
- Molina
- MultiPlan PPO
- PHCS Network PPO
- Principal Life
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Super Doctor
Education
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National Institutes of Health Clinical Center -
Johns Hopkins University -
University of Chicago Pritzker School of Medicine
Hospital
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Texas Children's Hospital
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