Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Mass Gen Hosp
Neurology
Dr. Kevin J. Staley, MD
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Kevin Staley is an expert in the field of Neurology. He went to University of California San Diego School of Medicine. University of California San Diego School of Medicine is ranked 17 in research and 19 in primary care medicine He received 1 awards: "Regional Top Doctor". Kevin Staley is a published doctor as well. He has 101 publications published. The latest was: Developmental expression of C1C-2 in the rat nervous system.
Publications
- Acute and Chronic Efficacy of Bumetanide in an in vitro Model of Posttraumatic Epileptogenesis.
- Novel determinants of the neuronal Cl- concentration.
- Response to comments on "Local impermeant anions establish the neuronal chloride concentration".
- Local impermeant anions establish the neuronal chloride concentration.
- Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's Disease model.
- Epilepsy therapy development: Technical and methodologic issues in studies with animal models.
- Diphenytoin, Riluzole and Lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity.
- PI3K-Akt Signaling Activates mTOR-Mediated Epileptogenesis in Organotypic Hippocampal Culture Model of Post-Traumatic Epilepsy.
- Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic Acid in adult hippocampal interneurons.
- Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro.
- Diuretics and epilepsy: Will the past and present meet?
- Response to ''a claim for caution in the use of promising bumetanide to treat neonatal seizures''.
- Interictal spikes: Harbingers or causes of epilepsy?
- The time course of acquired epilepsy: Implications for therapeutic intervention to suppress epileptogenesis.
- Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport.
- Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.
- The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.
- Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin.
- Is neuronal death necessary for acquired epileptogenesis in the immature brain?
- EEG spike activity precedes epilepsy after kainate-induced status epilepticus.
- Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy.
- Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.
- Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus.
- Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport.
- Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1.
- Development of spontaneous recurrent seizures after kainate-induced status epilepticus.
- Hyperactive interneurons impair learning in a neurofibromatosis model.
- Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia.
- The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures.
- Does plasticity of the GABA(A) reversal potential contribute to epileptogenesis?
- Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.
- Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons.
- Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
- Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models.
- NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network.
- Neurons skip a beat during fast ripples.
- Desynchronization of glutamate release prolongs synchronous CA3 network activity.
- How does the balance of excitation and inhibition shift during epileptogenesis?
- Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.
- Interictal spikes and epileptogenesis.
- Laser scanning photostimulation: new evidence for enhanced recurrent excitation in a model of posttraumatic epilepsy.
- A thalamic sleep tonic.
- Wrong-way chloride transport: is it a treatable cause of some intractable seizures?
- Adenosine and ATP link PCO2 to cortical excitability via pH.
- NKCC1 transporter facilitates seizures in the developing brain.
- Chronic cortical injury and epileptogensis: a possible role for intracellular chloride homeostasis.
- Mechanisms of fast ripples in the hippocampus.
- Role of the depolarizing GABA response in epilepsy.
- Transition from interictal to ictal activity in limbic networks in vitro.
- Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus.
- Convulsant and anticonvulsant effects on spontaneous CA3 population bursts.
- The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies?
- Diuretics as Antiepileptic Drugs: Should We Go with the Flow?
- Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends.
- The association between ambulance hospital turnaround times and patient acuity, destination hospital, and time of day.
- Transfection with hsp70i protects rat dorsal root ganglia neurones and glia from heat stress.
- Transgenic modelling of neurodegenerative events gathers momentum.
- Stroke: recovery inhibitors under attack.
- The human fetal auditory evoked potential.
- Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.
- Network mechanisms for fast ripple activity in epileptic tissue.
- Salt and wounds: a new mechanism for neuropathic pain.
- Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition.
- A woman''s prerogative.
- Carts, Horses, and Push-Pull Regulation of EGABA in Neonatal Seizures.
- Recognition of partially occluded and rotated images with a network of spiking neurons.
- Epileptic seizure detection.
- Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.
- High times for memory: cannabis disrupts temporal coordination among hippocampal neurons.
- Neuroscience. Epileptic neurons go wireless.
- Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy.
- A new form of feedback at the GABA(A) receptor.
- A new synaptic plasticity rule for networks of spiking neurons.
- A novel apparatus for lateral fluid percussion injury in the rat.
- Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines.
- Do interictal spikes drive epileptogenesis?
- The role of an inwardly rectifying chloride conductance in postsynaptic inhibition.
- The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy.
- Effects of synaptic depression and recovery on synchronous network activity.
- Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel.
- Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis.
- Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system.
- Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport.
- Quantal GABA release: noise or not?
- Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses.
- Presynaptic modulation of CA3 network activity.
- Developmental expression of C1C-2 in the rat nervous system.
- Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibit...
- Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors.
- Cell properties in the epileptic hippocampus.
- Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells.
- Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release.
- Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings.
- Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance.
- The balance between excitation and inhibition in dentate granule cells and its role in epilepsy.
- The electrophysiology of dentate gyrus granule cells in whole-cell recordings.
- Statistical model relating CA3 burst probability to recovery from burst-induced depression at recurrent collateral synapses.
- The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.
- Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury.
- Kynurenic acid has a dual action on AMPA receptor responses.
Schools
University of California At San Diego
Conditions Treated
- Cerebrovascular Disease
- Migraine
Doctors Specialties
- Pediatric Neurology
- Neurology
Accepted Insurances
Awards
- Regional Top Doctor
Education
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University of California San Diego -
University of California San Diego School of Medicine
Hospital
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Brigham and Women's Hospital -
Massachusetts General Hospital
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