Clinical Fellow in Surgery, Massachusetts General Hospital
Neurosurgery
Dr. Kristopher T. Kahle, MD
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Dr. Kristopher T. Kahle practices Neurosurgery. He graduated from Yale University School of Medicine. Yale University School of Medicine is a one of the best medicals schools. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine Kristopher Kahle is a published doctor and has 95 publications published. The lastest was: 'Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia.'
Publications
- Hydrocephalus in children.
- A novel method to study cerebrospinal fluid dynamics in rats.
- Response to comments on "Local impermeant anions establish the neuronal chloride concentration".
- Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2-Mediated Chloride Extrusion in Peripheral Neuropathic P...
- Local impermeant anions establish the neuronal chloride concentration.
- Dysregulation of diverse ion transport pathways controlling cell volume homoestasis contribute to neuroglial cell injury following ischemic stroke.
- Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2.
- Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema.
- Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury.
- The incidence of complications in elective cranial neurosurgery associated with dural closure material.
- Endoscopic burr hole evacuation of an acute subdural hematoma.
- Outcomes in Severe Middle Cerebral Artery Ischemic Stroke.
- The SLC12 family of electroneutral cation-coupled chloride cotransporters.
- Induced and Sustained Hypernatremia for the Prevention and Treatment of Cerebral Edema Following Brain Injury.
- The DECRA Trial and Decompressive Craniectomy in Diffuse Traumatic Brain Injury: Is Decompression Really Ineffective?
- Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: As good as it gets, or an iatrogenic secondary insult?
- Deep brain stimulation for medically refractory life-threatening status dystonicus in children.
- The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury.
- A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis.
- Novel Treatment Targets for Cerebral Edema.
- Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques.
- Diffuse central neurocytoma with craniospinal dissemination.
- Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect foll...
- Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy.
- Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease.
- Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics.
- Familial Chiari malformation: case series.
- Diuretics and epilepsy: Will the past and present meet?
- Craniectomy in diffuse traumatic brain injury.
- Surgical treatment and outcomes of metastatic breast cancer to the spine.
- Determinants of initial bone graft volume loss in posterolateral lumbar fusion.
- Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection.
- WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters.
- Determination of geographic variance in stroke prevalence using Internet search engine analytics.
- Giant thoracic meningocele associated with neurofibromatosis 1.
- Response to ''a claim for caution in the use of promising bumetanide to treat neonatal seizures''.
- Managing malignant cerebral infarction.
- Dural Scalp and Intracranial Hemangiomas Causing Hydrocephalus and Venous Sinus Thrombosis in an Infant.
- Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport.
- Hyponatremia associated with Ipilimumab-induced hypophysitis.
- Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals.
- Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital.
- EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer.
- Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.
- Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4.
- Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury.
- Functional genomics to explore cancer cell vulnerabilities.
- Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport.
- Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1.
- Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child.
- Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
- The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures.
- Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
- A novel protein kinase signaling pathway essential for blood pressure regulation in humans.
- Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy.
- Molecular physiology of the WNK kinases.
- An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.
- WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
- WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters.
- Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.
- WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway.
- WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
- WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.
- Hypertension, age, and location predict rupture of small intracranial aneurysms.
- Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch.
- Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
- WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
- WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
- WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
- Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
- ERK8, a new member of the mitogen-activated protein kinase family.
- Chordoma: current concepts, management, and future directions.
- DNA damage response and repair: insights into strategies for radiation sensitization of gliomas.
- Glioblastoma mimicking an arteriovenous malformation.
- Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample.
- Cerebral revascularization for the treatment of complex intracranial aneurysms of the posterior circulation: microsurgical anatomy, techniques and outcomes.
- Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms.
- Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity.
- Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample.
- En bloc excision of a dermal sinus tract.
- Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.
- The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture.
- Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis.
- Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature.
- Roles of the cation-chloride cotransporters in neurological disease.
- WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).
- WNK kinases: molecular regulators of integrated epithelial ion transport.
- ERK7 is an autoactivated member of the MAPK family.
- Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport.
- WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.
- Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia.
- The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters.
- Treatment of Edema Associated With Intracerebral Hemorrhage.
- Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia.
Schools
Yale University
Doctors Specialties
- Neurosurgery
Accepted Insurances
Education
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Massachusetts General Hospital -
Yale University School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1063603181 |
| Last Name Of The Provider | KAHLE |
| First Name Of The Provider | KRISTOPHER |
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