Professor, Internal Medicine, Ohio State University College of Medicine
Infectious Disease
Dr. Larry S. Schlesinger, MD
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Dr. Larry S. Schlesinger works in the field of Infectious Disease. He went to Rutgers Robert Wood Johnson Medical School. Rutgers Robert Wood Johnson Medical School has a rank of 74 in research and a 67 in primary care Larry S. Schlesinger, MD is a published MD as well. He has 77 publications published. The latest was: -Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206).
Publications
- γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206).
- Keratinocyte Growth Factor Administration Attenuates Murine Pulmonary Mycobacterium tuberculosis Infection through Granulocyte-Macrophage Colony-stimulating Factor (GM...
- Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.
- Design and synthesis of novel anti-tuberculosis agents from the celecoxib pharmacophore.
- Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.
- The Global One Health Paradigm: Challenges and Opportunities for Tackling Infectious Diseases at the Human, Animal, and Environment Interface in Low-Resource Settings.
- Mycobacterium tuberculosis Decreases Human Macrophage IFN-γ Responsiveness through miR-132 and miR-26a.
- Macrophage immunoregulatory pathways in tuberculosis.
- Characterization of lung inflammation and its impact on macrophage function in aging.
- Estrogen modulation of endosome-associated toll-like receptor 8: An IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.
- Molecular composition of the alveolar lining fluid in the aging lung.
- Exploitation of the Macrophage Mannose Receptor (CD206) in Infectious Disease Diagnostics and Therapeutics.
- Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity.
- Host-pathogen interactions in tuberculosis patients with type 2 diabetes mellitus.
- Delivery of host cell-directed therapeutics for intracellular pathogen clearance.
- GALLIUM NITRATE IS EFFICACIOUS IN MURINE MODELS OF TUBERCULOSIS AND INHIBITS KEY BACTERIAL FE-DEPENDENT ENZYMES.
- Macrophages in tuberculosis: friend or foe.
- Changes in the major cell envelope components of Mycobacterium tuberculosis during in vitro growth.
- Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis.
- A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.
- Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis.
- Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene.
- Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.
- A Mathematical Model of CR3/TLR2 Crosstalk in the Context of Francisella tularensis Infection.
- Characterization of Clinical and Environmental Mycobacterium avium Spp. Isolates and Their Interaction with Human Macrophages.
- MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis.
- Pulmonary surfactant protein-A and surfactant lipids up-regulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages.
- Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization.
- The acid phosphatase AcpA is secreted in vitro and in macrophages by Francisella spp.
- Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.
- Comparative Transcriptional Study of the Putative Mannose Donor Biosynthesis Genes in Virulent Mycobacterium tuberculosis and Attenuated Mycobacterium bovis BCG Strains.
- Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.
- Pseudomonas aeruginosaPsl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization.
- Structural differences in lipomannans from pathogenic and non-pathogenic mycobacteria that impact CD1b-restricted T cell responses.
- Human Lung Hydrolases Delineate Mycobacterium tuberculosis-Macrophage Interactions and the Capacity To Control Infection.
- Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin.
- Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune res...
- Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes.
- Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids.
- Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent.
- Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma.
- Pseudo-outbreak of "Mycobacterium paraffinicum" infection and/or colonization in a tertiary care medical center.
- Concerns about "Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study".
- Modeling the immune rheostat of macrophages in the lung in response to infection.
- Pharmacological exploitation of an off-target antibacterial effect of the cyclooxygenase-2 inhibitor celecoxib against Francisella tularensis.
- Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.
- MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.
- Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by hum...
- Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan.
- Evasion of complement-mediated lysis and complement C3 deposition are regulated by Francisella tularensis lipopolysaccharide O antigen.
- The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.
- Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages.
- Characterization of "Mycobacterium paraffinicum" associated with a pseudo-outbreak.
- Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion.
- Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis.
- Francisella tularensis induces IL-23 production in human monocytes.
- Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages.
- AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence.
- Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages.
- Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages.
- Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recogniti...
- Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.
- Mycobacterium tuberculosis binding to human surfactant proteins A and D, fibronectin, and small airway epithelial cells under shear conditions.
- Endocytic pathway for surfactant protein A in human macrophages: binding, clathrin-mediated uptake, and trafficking through the endolysosomal pathway.
- The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis.
- Pulmonary surfactant protein A activates a phosphatidylinositol 3-kinase/calcium signal transduction pathway in human macrophages: participation in the up-regulation o...
- Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity.
- Complement protein C3 binding to Mycobacterium tuberculosis is initiated by the classical pathway in human bronchoalveolar lavage fluid.
- The nature of extracellular iron influences iron acquisition by Mycobacterium tuberculosis residing within human macrophages.
- Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis.
- Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages.
- Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors.
- Surfactant protein D inhibition of human macrophage uptake of Mycobacterium tuberculosis is independent of bacterial agglutination.
- Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes.
- Phagocytosis via Complement or Fc-Gamma Receptors Is Compromised in Monocytes from Type 2 Diabetes Patients with Chronic Hyperglycemia.
- Modeling the Mycobacterium tuberculosis Granuloma - the Critical Battlefield in Host Immunity and Disease.
Schools
Rutgers Medical School
University Mich Med Center
UCLA Med Center
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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UCLA Medical Center -
University of Michigan Hospitals and Health Centers -
Rutgers Robert Wood Johnson Medical School
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