professor of oncoloy, medicine, and immunology and microbiology
Hematology
Dr. Lawrence G. Lum, MD
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Doctor Lawrence G. Lum, MD is an expert in the field of Hematology. He went to University of California San Francisco School of Medicine. University of California San Francisco School of Medicine is a top medical university. University of California San Francisco School of Medicine is ranked 3 in research and 3 in primary care medicine Lawrence has written publications. He has 101 publications published with PubMed. The lastest publication is: 'T cell activation modulates retrovirus-mediated gene expression.' Dr. Lawrence G. Lum is registered with Medicare and accepts Medicare payments.
Publications
- Targeting Clonogenic Myeloma Precursor Cells Decreases These Cells and Induces Transferable Antimyeloma Immunity.
- Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
- Low blood lymphocyte count at 30 days post transplant predicts worse acute GVHD and survival but not relapse in a large retrospective cohort.
- Hematopoietic Cell Transplantation and Cellular Therapeutics in the Treatment of Childhood Malignancies.
- Incidence, Risk Factors, and Outcome of Cytomegalovirus Viremia and Gastroenteritis in Patients with Gastrointestinal Graft-versus-Host Disease.
- The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
- Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT.
- Maspin expression in prostate tumor elicits host anti-tumor immunity.
- Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens.
- Successful hematopoietic stem cell collection in patients who fail initial plerixafor mobilization for autologous stem cell transplant.
- High Incidence of Severe aGVHD with Tacrolimus and Mycophenolate Mofetil in a Large Cohort of Related and Unrelated Allogeneic Transplant Patients.
- KIF14 Promotes AKT Phosphorylation and Contributes to Chemoresistance in Triple-Negative Breast Cancer.
- Extensive Toxic Epidermal Necrolysis Versus Acute Graft Versus Host Disease After Allogenic Hematopoietic Stem-Cell Transplantation: Challenges in Diagnosis and Manage...
- Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
- Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: A pilot study.
- Signaling: Making a leaner Hedgehog.
- Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma.
- A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer.
- The Development of Highly Potent Inhibitors for Porcupine.
- Long-term follow up of patients proceeding to transplant using plerixafor mobilized stem cells and incidence of secondary myelodysplastic syndrome/AML.
- Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies.
- Generation and immunologic functions of Th17 cells in malignant gliomas.
- Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells.
- A Phase I Dose-Escalation Trial of High-Dose Melphalan with Palifermin for Cytoprotection Followed by Autologous Stem Cell Transplantation for Patients with Multiple M...
- Anti-CD3 × anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets.
- Anti-Thymocyte Globulin (Thymoglobulin), Tacrolimus, and Sirolimus as Acute Graft-versus-Host Disease Prophylaxis for Unrelated Hematopoietic Stem Cell Transplantation.
- Melphalan 180 mg/m(2) can be Safely Administered as Conditioning Regimen prior to an Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma Patients with Crea...
- Targeting T cells with bispecific antibodies for cancer therapy.
- The immunological contribution of NF-?B within the tumor microenvironment: A potential protective role of zinc as an anti-tumor agent.
- Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-?1 activity.
- A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived s...
- Large pericardial effusion as a complication in adults undergoing SCT.
- Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.
- Activated T cells from umbilical cord blood armed with anti-CD3 × anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal alloge...
- In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells.
- Induction of specific cellular and humoral responses against renal cell carcinoma after combination therapy with cryoablation and granulocyte-macrophage colony stimula...
- Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
- Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited.
- Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: utility of cycle threshold values of qualita...
- Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart.
- Cancer therapy with bispecific antibodies: Clinical experience.
- Triple MEL100 therapy in multiple myeloma.
- Nonabsorbable corticosteroids use in the treatment of gastrointestinal graft-versus-host disease.
- A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.
- Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction.
- Antibody targeting of stem cells to infarcted myocardium.
- Tissue engineering and stem cell therapy for myocardial repair.
- Prevalence of off-target effects in Drosophila RNA interference screens.
- A genomewide screen for components of the RNAi pathway in Drosophila cultured cells.
- The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
- Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study.
- Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation.
- The new face of bispecific antibodies: targeting cancer and much more.
- Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model.
- Retargeting T cells and immune effector cells with bispecific antibodies.
- Virtual reality of stem cell transplantation to repair injured myocardium.
- Preclinical studies comparing different bispecific antibodies for redirecting T cell cytotoxicity to extracellular antigens on prostate carcinomas.
- T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B cells and bypass complement-mediated rituximab resistance in vitro.
- Extensive phosphorylation of Smoothened in Hedgehog pathway activation.
- Anti-CD3 x anti-HER2 bispecific antibody effectively redirects armed T cells to inhibit tumor development and growth in hormone-refractory prostate cancer-bearing seve...
- The Hedgehog response network: sensors, switches, and routers.
- How important is HER2/neu amplification and expression when selecting patients for HER2/neu-targeted therapies?
- Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model.
- Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).
- Differentiation hotspots: the deterioration of hierarchy and stochasm.
- Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium.
- Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
- Phase I/II study of treatment of stage IV breast cancer with OKT3 x trastuzumab-armed activated T cells.
- The marrow stem cell: the continuum.
- Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells.
- Potential role for ADAM15 in pathological neovascularization in mice.
- Marrow stem cell potential within a continuum.
- Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.
- The new stem cell biology.
- Life or death of T cells with antigen-specific receptors--using T cells for cancer adoptive immunotherapy/gene therapy.
- Immune modulation in cancer patients after adoptive transfer of anti-CD3/anti-CD28-costimulated T cells-phase I clinical trial.
- Activated T-cell and bispecific antibody immunotherapy for high-risk breast cancer. Bench to bedside.
- Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors.
- Anti-CD3/anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma.
- Anti-CD3/anti-CD28 monoclonal antibody-coated suture enhances the immune response of patients with head and neck squamous cell carcinoma.
- T cells coactivated with immobilized anti-CD3 and anti-CD28 as potential immunotherapy for cancer.
- T cell-based immunotherapy for cancer: a virtual reality?
- T cell activation modulates retrovirus-mediated gene expression.
- Anti-CD3-activated splenocytes enhance survival in lethally irradiated mice after transplant of syngeneic hematopoietic stem cells.
- Clinical course and outcome of patients with Hodgkin''s disease who progress after autologous transplantation.
- Sinus disease in the bone marrow transplant population: incidence, risk factors, and complications.
- Signal transduction by B and T cells early after bone marrow transplantation: B cell calcium flux responses are intact whereas lack of CD4 cells accounts for impaired ...
- Prevention of hemorrhagic cystitis following allogeneic bone marrow transplant preparative regimens with cyclophosphamide and busulfan: role of continuous bladder irri...
- Bone marrow transplantation for multiple myeloma: the Wayne State experience.
- Prospective comparative trial of autologous versus allogeneic bone marrow transplantation in patients with non-Hodgkin's lymphoma.
- Graft failure in children receiving HLA-mismatched marrow transplants with busulfan-containing regimens.
- A 70-amino acid zinc-binding polypeptide fragment from the regulatory chain of aspartate transcarbamoylase causes marked changes in the kinetic mechanism of the cataly...
- Phase I study of alpha-interferon augmentation of cyclosporine-induced graft versus host disease in recipients of autologous bone marrow transplantation.
- Correlation of colony-forming cells, long-term culture initiating cells and CD34+ cells in apheresis products from patients mobilized for peripheral blood progenitors ...
- Preclinical studies using immobilized OKT3 to activate human T cells for adoptive immunotherapy: optimal conditions for the proliferation and induction of non-MHC-rest...
- Constitutive and mitogen-stimulated cytokine mRNA expression by peripheral blood mononuclear cells from most autologous and allogeneic bone marrow transplant recipient...
- Coactivation with anti-CD28 monoclonal antibody enhances anti-CD3 monoclonal antibody-induced proliferation and IL-2 synthesis in T cells from autologous bone marrow t...
- Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination.
- Preclinical studies for adoptive immunotherapy in bone marrow transplantation. Generation of anti-CD3 activated cytotoxic T cells from normal donors and autologous bon...
- Targeted delivery of siRNA to activated T Cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.
Schools
University Of Ca School Of Med
Moffitt Hospital University Of Ca
University Of Co School Of Med
Doctors Specialties
- Pediatrics
- Hematology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Blue Care Network PCP Focus Network
- Group Employees PPO
- Great West Healthcare-Cigna PPO
- Cofinity PPO
- Commercial Insurance Company
- Choice Care PPO
- Medicaid
- Medicare MCR
- Priority PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Education
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University of Colorado -
UCSF -
University of California San Francisco School of Medicine
Hospital
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DMC - Detroit Receiving Hospital -
DMC Harper University Hospital -
University of Texas Southwestern Medical Center
Drug Facts
| NPI NUMBER | 1689671455 | |
| NPPES Provider LastName | LUM | |
| NPPES Provider FirstName | LAWRENCE | |
| NPPES Provider ZIPCode | 482012013 | |
| NPPES Provider State | MI | |
| Specialty Description | Hematology/Oncology | |
| Total Claim Count | 54.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1689671455 |
| Last Name Of The Provider | LUM |
| First Name Of The Provider | LAWRENCE |
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