Physician
Ophthalmology
Dr. Leo T. Chylack Jr., MD
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Chylack works in the field of Ophthalmology. He studied medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Chylack has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Mechanism of "hypoglycemic" cataract formation in the rat lens. II. Further studies on the role of hexokinase instability.'
Publications
- Appraisal of lens opacity with mometasone furoate/formoterol fumarate combination in patients with COPD or asthma.
- NASCA Report 2: Longitudinal Study of Relationship of Exposure to Space Radiation and Risk of Lens Opacity.
- NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.
- Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching.
- Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density.
- Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration.
- Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities.
- Dietary fat intake and early age-related lens opacities.
- Long-term nutrient intake and 5-year change in nuclear lens opacities.
- LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.
- Overall adherence to the dietary guidelines for americans is associated with reduced prevalence of early age-related nuclear lens opacities in women.
- Weight status, abdominal adiposity, diabetes, and early age-related lens opacities.
- Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells.
- Clinical application of the lens opacities classification system III in the performance of phacoemulsification.
- Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities.
- Radiation cataractogenesis: epidemiology and biology.
- Letter: Photomacrography of the crystalline normal and cataractous lens.
- HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis.
- Effects of iron ions, protons and X rays on human lens cell differentiation.
- Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group.
- [Antioxidant micronutrients and cataract. Review and comparison of the AREDS and REACT cataract studies].
- Comparison of microdissected sections from the human cataractous lens by antisera to synthetic peptides.
- Quantitation of high molecular weight protein aggregates in opaque and transparent parts from the same human cataractous lens.
- Early-onset pauciarticular juvenile rheumatoid arthritis associated with human leukocyte antigen-DRw5, iritis, and antinuclear antibody.
- Cataracts in the exfoliation syndrome (fibrillopathia epitheliocapsularis).
- Calcium-containing opacities in the human lens.
- Response of the lens to oxidative-osmotic stress.
- Phase separation in rat lenses cultured in low glucose media.
- Classification of human senile cataractous changes by the American Cooperative Cataract Research Group (CCRG) method. I. Instrumentation and technique.
- The effect of freezing on human cortical cataracts.
- The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.
- Differences in the susceptibility of various aldose reductases to inhibition. II.
- Classification of human senile cataractous change by the American Cooperative Cataract Research Group (CCRG) method: III. The association of nuclear color (sclerosis) ...
- Classification of human senile cataractous change by the American Cooperative Cataract Research Group (CCRG) method: II. Staged simplification of cataract classification.
- Direct measurement of polyol pathway activity in the ocular lens.
- GSSG-reducing activity in lenses deficient in glucose-6-phosphate dehydrogenase.
- Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: selectivity among HLA-DR5 haplotypes.
- Classification of human cataractous change by the American Cooperative Cataract Research Group method.
- Change in the protein tertiary structure with non-enzymatic glycosylation of calf alpha-crystallin.
- Supplementing glucose metabolism in human senile cataracts.
- Calf lens phosphofructokinase: purification by single-step affinity chromatography and partial characterization.
- Age and the control of glycolysis in the rat lens.
- Altered phosphate metabolism in the intact rabbit lens under high glucose conditions and its prevention by an aldose reductase inhibitor.
- Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus.
- Mechanisms of senile cataract formation.
- Early-onset pauciarticular juvenile rheumatoid arthritis. A histopathologic study.
- Kinetics of calf lens phosphofructokinase activity at physiological substrate concentrations.
- A biochemical evaluation of a cataract induced in a high-glucose medium.
- Nature and distribution of two distinct forms of hexokinase within the mammalian lens.
- The interaction of the lens and the vitreous. I. The high glucose cataract in a lens-vitreous preparation.
- Sugar cataract.
- Thermo-instability of rat lens hexokinase.
- The interaction of the lens and the vitreous. II. The influence of the vitreous on lens trauma, water and electrolyte balance and osmotic stress.
- Human lens hexokinase.
- Control of glycolysis in the lens.
- Spectroscopic studies on human lens crystallins.
- Fluorescence studies on tryptophan and sulfhydryl group changes of bovine lens crystallins in a photodynamic system.
- Light scattering of whole excised human cataractous lenses. Relationships between different light scattering parameters.
- Glucose metabolism in the calf lens.
- Sorbitol/fructose metabolism in the lens.
- Validity and reproducibility of the Cooperative Cataract Research Group (CCRG) cataract classification system.
- The effect of oxidation on sorbitol pathway kinetics.
- Freezable and non-freezable water content of cataractous human lenses.
- Inexpensive stereoscopic CCRG camera for lens/cataract photography in vitro.
- Acute glucose-derived osmotic stress in rabbit lenses.
- Sorbitol production in the lens: a means of counteracting glucose-derived osmotic stress.
- Dynamic light scattering in the intact rabbit lens. Its relation to protein concentration.
- Topographic correspondence between total and non-freezable water content and the appearance of cataract in human lenses.
- Glucose metabolism by human cataracts in culture.
- In vivo measurement of the aging rabbit lens using quasielastic light scattering.
- Non-enzymatic glycosylation in human diabetic lens crystallins.
- Change in sulfhydryl group microenvironment of calf lens alpha-crystallin by 300 nm light.
- Progress toward developing a cataract classification system.
- Quantitative detection of the molecular changes associated with early cataractogenesis in the living human lens using quasielastic light scattering.
- Sources of variance in the objective documentation of human cataractous change with Topcon SL-45 and Neitz-CTR retroillumination photography and computerized image ana...
- Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels.
- Lens hexokinase deactivation by near-UV irradiation.
- Standardization and analysis of digitized photographic data in the longitudinal documentation of cataractous growth.
- Front surface fluorometric study of lens insoluble proteins.
- Antioxidant status in persons with and without senile cataract.
- Lens Opacities Classification System.
- Evaluation of a Lens Opacities Classification System.
- Glucose flux and the redox state of pyridine dinucleotides in the rat lens.
- The protective effect of glucose on soluble rat lens hexokinase in the presence of oxidative stress.
- Regional sensitivity to hypoglycemia within the rabbit lens epithelium.
- Lens opacities classification system II (LOCS II)
- An enriched set of features of nuclear cataract identified by multidimensional scaling.
- Allopurinol use and the risk of cataract formation.
- Strategies for measuring the rate of age-related cataract formation in vivo.
- Elemental and structural studies of the rat galactose cataract.
- Objective measurement of cortical and subcapsular opacification in retroillumination photographs.
- Intermediary metabolism of the lens: a historical perspective 1928-1989.
- Recent studies on photodamage to the eye with special reference to clinical phototherapeutic procedures.
- The Lens Opacities Case-Control Study. Risk factors for cataract.
- Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention.
- Indirect spectral transmission ratio measurements of the aging crystalline lens nucleus.
- The characterization of the hexokinases in several tissues of the calf eye.
- Mechanism of "hypoglycemic" cataract formation in the rat lens. I. The role of hexokinase instability.
- Ocular manifestations of juvenile rheumatoid arthritis.
- Mechanism of "hypoglycemic" cataract formation in the rat lens. II. Further studies on the role of hexokinase instability.
Schools
Harvard Medical School
Boston City Hospital
Mass Ee Infirm
Doctors Specialties
- Ophthalmology
Accepted Insurances
Education
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Massachusetts Eye & Ear Infirmary -
Boston University Medical Center -
Harvard Medical School
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