Professor of Medicine, UCLA-David Geffen School of Medicine
Cardiology
Dr. Linda L. Demer, MD
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Linda Demer works in the field of Cardiology. She attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care She received awards:"Elected Member". Linda L. Demer, MD is a published doctor and has 99 publications published. The lastest was: 'Osteopontin. Between a rock and a hard plaque.'
Publications
- Conflicting forces of warfarin and matrix gla protein in the Artery wall.
- Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease.
- Inflammatory, metabolic, and genetic mechanisms of vascular calcification.
- FGF23 protein expression in Coronary arteries is associated with impaired kidney function.
- Effects of bioactive lipids and lipoproteins on bone.
- Mechanism of Hyperlipidemia-induced parathyroid hormone (PTH) resistance: A role of PTH receptor and reactive oxygen species in preosteoblasts.
- Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.
- Regulatory circuits controlling vascular cell calcification.
- Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells.
- Preferred Mitotic Orientation in Pattern Formation by Vascular Mesenchymal Cells.
- Patterns of periodic holes created by increased cell motility.
- Focal High Cell Density Generates a Gradient of Patterns in Self-Organizing Vascular Mesenchymal Cells.
- Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics.
- A Dynamic Model of Calcific Nodule Destabilization in Response to Monocytes- and Oxidized Lipids-Induced Matrix Metalloproteinases.
- Calcific Aortic valve disease: not simply a degenerative process: a review and agenda for research from the national heart and lung and blood institute Aortic stenosis...
- The role of cellular cholesterol metabolism in vascular cell calcification.
- Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids.
- Thematic series on the pathobiology of vascular calcification: an introduction.
- Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells.
- Runx2-Upregulated Receptor Activator of Nuclear Factor {kappa}B Ligand in Calcifying Smooth Muscle Cells Promotes Migration and Osteoclastic Differentiation of Macroph...
- Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro.
- Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss.
- Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability.
- Mechanisms linking osteoporosis with cardiovascular calcification.
- Nanoscale architecture in atherosclerotic calcification.
- Hyperlipidemia impairs osteoanabolic effects of PTH.
- Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification.
- Vitamin D and osteogenic differentiation in the Artery wall.
- Vascular calcification: pathobiology of a multifaceted Disease.
- A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells".
- Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
- Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.
- Mineralocorticoid receptor activation promotes vascular cell calcification.
- Mechanical response of a calcified plaque model to fluid shear force.
- Pitting phosphate transport inhibitors against vascular calcification.
- Return to ectopia: stem cells in the Artery wall.
- Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase an...
- Skeleton key to vascular Disease.
- Mesenchymal stem cells and the Artery wall.
- Vascular calcification: mechanisms and clinical ramifications.
- Pattern formation by vascular mesenchymal cells.
- Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses.
- Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo.
- Multilineage potential of cells from the Artery wall.
- Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture.
- Monocyte recruitment to endothelial cells in response to oscillatory shear stress.
- Vascular calcification and its relation to bone calcification: possible underlying mechanisms.
- Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells.
- High-density lipoprotein regulates calcification of vascular cells.
- Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt).
- 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.
- Adipose rex: fat and fats that rule differentiation.
- Monocyte/macrophage regulation of vascular calcification in vitro.
- Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification.
- The roles of lipid oxidation products and receptor activator of nuclear factor-?B signaling in atherosclerotic calcification.
- PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification.
- The bone-vascular axis in chronic kidney Disease.
- Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids.
- Systems biology of vascular calcification.
- The hemosteoblast: friend or foe?
- Expression and function of PPARgamma in rat and human vascular smooth muscle cells.
- Systolic blood pressure and mortality.
- Assessing stenosis severity: Coronary flow reserve, collateral function, quantitative Coronary arteriography, positron imaging, and digital subtraction angiography. A ...
- Determinants of instantaneous pressure in canine left ventricle. Time and volume specification.
- Regulatory mechanisms in vascular calcification.
- T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.
- Murine models of atherosclerotic calcification.
- Regulation of RANKL-induced osteoclastic differentiation by vascular cells.
- Novel mechanisms in accelerated vascular calcification in renal Disease patients.
- Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids.
- Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells.
- Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.
- Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.
- Osteopontin. Between a rock and a hard plaque.
- Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory.
- cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.
- Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?
- Active serum vitamin D levels are inversely correlated with Coronary calcification.
- Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of Coronary calcium mass measured by electron-beam computed tomography.
- Role of molecular regulation in vascular calcification.
- Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcificat...
- Calcifying subpopulation of bovine Aortic smooth muscle cells is responsive to 17 beta-estradiol.
- Lipid hypothesis of cardiovascular calcification.
- The atherosclerosis-calcification link?
- Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers.
- The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture.
- Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.
- Physician-scientists as missing persons. Association of Subspecialty Professors.
- Bone morphogenetic protein expression in human atherosclerotic lesions.
- A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human Aortic smooth muscle cells.
- Effect of calcification and formalin fixation on in vitro distensibility of human femoral arteries.
- Mechanical stimulation induces intercellular calcium signaling in bovine Aortic endothelial cells.
- TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.
- Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.
- Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen.
- Atherosclerotic calcification: relation to developmental osteogenesis.
- Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics.
- A skeleton in the atherosclerosis closet.
Schools
Johns Hopkins University School Of Medicine
Baylor College Of Med
University Tex Med School
Procedures Preformed
- Cardiac Imaging
- Cardiac Myocardial Perfusion Imaging
- Chest CT (incl. Heart and Lungs)
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomegaly
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
Education
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University of Texas Health Science Center -
Baylor College of Medicine -
Johns Hopkins University School of Medicine
Hospital
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Ronald Reagan UCLA Medical Center
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