Professor and Vice Chairman, Dept. of Medicine, Tufts Medical Center

Infectious Disease

Linden practices Infectious Disease. He graduated from Warren Alpert Medical School of Brown University. He received awards:"Regional Top Doctor", "Elected Member", "American Society for Clinical Investigation (ASCI)", "Teaching Citation", "Fellow", "Daland Fellowship", "Maxwell Finland Award" and "Sigma Xi". Linden is also published. He has 31 publications published. The lastest publication: "Adaptor Protein-3-Mediated Trafficking of TLR2 Ligands Controls Specificity of Inflammatory Responses but Not Adaptor Complex Assembly.' He accepts Medicare.

Publications

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• Adaptor Protein-3-Mediated Trafficking of TLR2 Ligands Controls Specificity of Inflammatory Responses but Not Adaptor Complex Assembly.
• Is there a place for xenodiagnosis in the clinic?
• Xenodiagnosis to Detect Borrelia burgdorferi Infection: A First-in-Human Study.
• KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer.
• Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing.
• TRIF mediates TLR2 dependent inflammatory responses to Borrelia burgdorferi.
• Oral vaccination with vaccinia virus expressing the tick antigen subolesin inhibits tick feeding and transmission of Borrelia burgdorferi.
• Lyme disease.
• Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.
• Identification of interspecies interactions affecting Porphyromonas gingivalis virulence phenotypes.
• Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease.
• Nest box-deployed bait for delivering oral vaccines to white-footed mice.
• Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance.
• Role of adrenomedullin in Lyme disease.
• Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis.
• Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
• Matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi.
• Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes.
• Taking a bite out of vector-transmitted infectious diseases.
• Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A.
• Role of aggrecanase 1 in Lyme arthritis.
• Update on the prevention, diagnosis, and treatment of Lyme disease.
• Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
• Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs.
• Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to inte...
• Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi.
• Role of novel protein kinase C isoforms in Lyme arthritis.
• Transposon mutagenesis as an approach to improved understanding of Borrelia pathogenesis and biology.
• A Two-Component System Regulates Hemin Acquisition in Porphyromonas gingivalis.
• Defining essential genes and identifying virulence factors of Porphyromonas gingivalis by massively parallel sequencing of transposon libraries (Tn-seq).

Schools

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• Brown University Alpert Medical School

• St Elizabeth39s Hospitalboston

• New England Med Center Ma

Doctors Specialties

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• Infectious Disease Medicine
• Infectious Disease

Accepted Insurances

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Awards

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• Regional Top Doctor
• Elected Member
• American Society for Clinical Investigation (ASCI)
• Teaching Citation
• Fellow
• Daland Fellowship
• Maxwell Finland Award
• Sigma Xi

Education

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• Warren Alpert Medical School of Brown University
• Brown University

Hospital

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• Tufts Medical Center

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1144336785
Last Name Of The Provider	HU
First Name Of The Provider	LINDEN
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