Professor, Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
Endocrinology
Dr. Mark A. Magnuson, MD
Mark Magnuson works in the field of Endocrinology. He received awards:"Elected Member". Mark A. Magnuson, MD is a published doctor. He has 101 publications published. The most current publication "Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system."
Publications
- Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.
- Insm1 promotes neurogenic proliferation in delaminated otic progenitors.
- Dominant and context-specific control of endodermal organ allocation by Ptf1a.
- The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth.
- Pancreas-specific cre driver lines and considerations for their prudent use.
- Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
- Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.
- Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
- Research Resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Consortium Interconnectivity Network: A Pilot Program to Aggregate...
- Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.
- Nkx2.2 repressor complex regulates islet ?-cell specification and prevents ?-to-?-cell reprogramming.
- Engineering Artificial Signaling Centers to Polarize Embryoid Body Differentiation.
- Loss of Foxd3 Results in Decreased {beta}-Cell Proliferation and Glucose Intolerance During Pregnancy.
- An RMCE-derived cyan fluorescent protein reporter allele for Pdx1.
- Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro.
- Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel.
- Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic {beta}-Cells Through Glycolysis and Calcium Channels.
- Control of pancreatic β cell regeneration by glucose metabolism.
- Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
- Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice.
- MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
- Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
- Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
- Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.
- Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.
- Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.
- Hepatic energy state is regulated by glucagon receptor signaling in mice.
- Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
- mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.
- New complexity in differentiating stem cells toward hepatic and pancreatic fates.
- Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.
- A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
- Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.
- Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.
- Hepatic glucose sensing: does flux matter?
- pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.
- A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
- Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.
- Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
- Obesity and the beta cell: lessons from leptin.
- Pancreatic glucokinase is activated by insulin-like growth factor-I.
- Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
- Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
- Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.
- Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
- Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.
- Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
- Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
- RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function.
- Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
- The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
- Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor.
- Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
- Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice.
- Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption.
- Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of bet...
- 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent...
- Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.
- Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.
- Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
- Strategies for the use of site-specific recombinases in genome engineering.
- Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.
- Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
- Generation of a conditional allele of the mouse prostaglandin EP4 receptor.
- Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection.
- Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
- Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.
- Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
- Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.
- Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats.
- Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].
- Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
- Of mice and MEN1: Insulinomas in a conditional mouse knockout.
- Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
- Gene-altered mice and metabolic flux control.
- Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
- Allosteric activators of glucokinase: potential role in diabetes therapy.
- Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
- Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
- Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model.
- Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
- Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
- A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.
- The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
- Generation and functional confirmation of a conditional null PPARgamma allele in mice.
- Conditional inactivation of the TGF-beta type II receptor using Cre:Lox.
- In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle.
- Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas.
- Caveats and considerations for performing pancreas-specific gene manipulations in the mouse.
- Rictor is a novel target of p70 S6 kinase-1.
- Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.
- Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.
- Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development.
- Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.
- Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.
- Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
- Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.
- Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor.
- Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucos...
- Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Schools
University of Ia Roy J amp L Carver Com
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
-
Vanderbilt University -
University of Rochester
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