Associate Professor, Pathology, University of Pittsburgh School of Medicine

Pathology

Mark H. Yazer, MD practices Pathology. Doctor Mark H. Yazer, MD has written publications. He has 79 publications published with PubMed. The lastest publication is: 'Things aren't always as they seem: what the randomized trials of red blood cell transfusion tell us about adverse outcomes (CME).'

Publications

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• Pretransfusion testing and transfusion of uncrossmatched erythrocytes.
• Things aren't always as they seem: what the randomized trials of red blood cell transfusion tell us about adverse outcomes (CME).
• Implementation of a simple electronic transfusion alert system decreases inappropriate ordering of packed red blood cells and plasma in a multi-hospital health care sy...
• Low frequency of anti-D alloimmunization following D+ platelet transfusion: the Anti-D Alloimmunization after D-incompatible Platelet Transfusions (ADAPT) study.
• Relative IgA-deficient recipients have an increased risk of severe allergic transfusion reactions.
• Letter on Bacterial contamination in platelet concentrates.
• Complications following an unnecessary peri-operative plasma transfusion and literature review.
• Trends in RBC Ordering and Use After Implementing Adaptive Alerts in the Electronic Computerized Physician Order Entry System.
• Stationary versus agitated storage of whole blood during acute normovolemic hemodilution.
• A centralized recipient database enhances the serologic safety of RBC transfusions for patients with sickle cell disease.
• Evaluation of real-time clinical decision support systems for platelet and cryoprecipitate orders.
• Stored platelet functionality is not decreased after warming with a fluid warmer.
• Clinical validation of risk stratification criteria for peripartum hemorrhage.
• Blood utilization after primary total joint arthroplasty in a large hospital network.
• Effect of blood bank storage on the rheological properties of male and female donor red blood cells.
• Routine use of a rapid test to detect bacteria at the time of issue for nonleukoreduced, whole blood-derived platelets.
• Ascorbic acid improves membrane fragility and decreases haemolysis during red blood cell storage.
• Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization.
• Changes in mechanical fragility and free hemoglobin levels after processing salvaged cardiopulmonary bypass circuit blood with a modified ultrafiltration device.
• How do I implement a hospital-based blood management program?
• The volume of returned red blood cells in a large blood salvage program: where does it all go? (CME).
• Transfusion-associated circulatory overload after plasma transfusion.
• Hemolysis and red blood cell mechanical fragility in shed blood after total knee arthroplasty.
• Quantification of changes in oxygen release from red blood cells as a function of age based on magnetic susceptibility measurements.
• A Novel A Subtype Allele that Demonstrates Allelic Competition.
• Hepatic function after genetically engineered pig liver transplantation in baboons.
• Receipt of older RBCs does not predispose D-negative recipients to anti-D alloimmunization.
• Weak A phenotypes associated with novel ABO alleles carrying the A2-related 1061C deletion and various missense substitutions.
• Cryoprecipitate prepared from plasma frozen within 24 hours after phlebotomy contains acceptable levels of fibrinogen and VIIIC.
• Use of the RQI test for bacterial screening of whole blood platelets.
• The role of the elution in antibody investigations.
• Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization?
• Enhanced detection of blood bank sample collection errors with a centralized patient database.
• Coagulation factor levels in plasma frozen within 24 hours of phlebotomy over 5 days of storage at 1 to 6 degrees C.
• Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.
• Investigation into A antigen expression on O2 heterozygous group O-labeled red blood cell units.
• A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices.
• Detection of anti-D in D- recipients transfused with D+ red blood cells.
• Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation.
• Modification of suction-induced hemolysis during cell salvage.
• Case report and literature review: transient Inab phenotype and an agglutinating anti-IFC in a patient with a gastrointestinal problem.
• The cis-AB blood group phenotype: fundamental lessons in glycobiology.
• Amino-acid substitution in the disordered loop of blood group B-glycosyltransferase enzyme causes weak B phenotype.
• The importance of disordered loops in ABO glycosyltransferases.
• Use of a pH meter for bacterial screening of whole blood platelets.
• What a difference 2 nucleotides make: a short review of ABO genetics.
• The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC.
• Tolerance to incompatible ABO blood group antigens is not observed following homograft implantation.
• The impact of suctioning RBCs from a simulated operative site on mechanical fragility and hemolysis.
• Significant association between ABO blood group and pancreatic cancer.
• The how''s and why''s of evidence based plasma therapy.
• Clinical studies of the effect of blood storage on patient outcomes.
• The M142T mutation causes B3 phenotype: three cases and an in vitro expression study.
• Preface. Transfusion in the year 2020: the future of blood transfusion.
• Genetically engineered pigs as a source for clinical red blood cell transfusion.
• On the complexity of D antigen typing: a handy decision tree in the age of molecular blood group diagnostics.
• Messages from national blood data collection reports.
• Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies.
• Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart grafts.
• The blood bank "black box" debunked: pretransfusion testing explained.
• The role of the Coombs test in evaluating hemolysis in adults.
• A dispermic chimera with mixed field blood group B and mosaic 46,XY/47,XYY karyotype.
• Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?
• What every physician should know about transfusion reactions.
• The Pittsburgh centralized transfusion model: less is more.
• The genetic and phenotypic basis of blood group A subtypes in Koreans.
• Kinetic studies on Korean serum cis-AB enzymes reveal diminished A and B transferase activities.
• The serological and genetic basis of the cis-AB blood group in Korea.
• ABO sequence analysis in a family with weak expression of blood group B.
• A novel B(var) allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele.
• The O2 allele: questioning the phenotypic definition of an ABO allele.
• Chimerism and mosaicism are important causes of ABO phenotype and genotype discrepancies.
• Serial oxygen equilibrium and kinetic measurements during RBC storage.
• The use of the mechanical fragility test in evaluating sublethal RBC injury during storage.
• Transfusion practice and safety: current status and possibilities for improvement.
• The Cromer blood group system: a review.
• Menopausal status affects the susceptibility of stored RBCs to mechanical stress.
• ABO-mismatched transfusions are not over-represented in febrile non-haemolytic transfusion reactions to platelets.

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Hospital

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• UPMC Passavant

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