UF Chief, Pulmonary, Critical Care and Sleep Medicine
Pulmonology
Dr. Mark L. Brantly, MD
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Dr. Mark L. Brantly practices Pulmonology. He went to medical school at University of Florida College of Medicine. University of Florida College of Medicine is ranked 43 in research and 78 in primary care medicine He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Mark L. Brantly, MD is also published. He has 98 publications published. The lastest publication: "Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors.' He accepts all Medicare patients.
Publications
- Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and Metabolism.
- Genome-wide Study of Percent Emphysema on CT in the General Population: The MESA Lung/SHARe Study.
- Reprogramming adipose tissue derived mesenchymal stem cells (AT-MSCs) into pluripotent stem cells by a mutant AAV vector.
- Appropriateness of Newborn Screening for Alpha-1 Antitrypsin Deficiency; Analysis and Recommendations from a Workshop.
- Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphang...
- Safety and Pharmacokinetics of 120 mg/kg versus 60 mg/kg Weekly Intravenous Infusions of Alpha-1 Proteinase Inhibitor in Alpha-1 Antitrypsin Deficiency: A Multicenter,...
- Biochemical Efficacy and Safety of a New, Ready-to-Use, Liquid Alpha-1-Proteinase Inhibitor, GLASSIA (Alpha-Proteinase Inhibitor (Human), Intravenous).
- Alpha-1 Antitrypsin Augmentation Therapy and Biomarkers of Elastin Degradation.
- The challenge of detecting alpha-1 antitrypsin deficiency.
- Development, validation and use of ELISA for antibodies to human alpha-1 antitrypsin.
- Liver Test Results Do Not Identify Liver Disease in Adults With α(1)-Antitrypsin Deficiency.
- Alphaâ-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis.
- Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1.
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.
- IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.
- Phase I trial of intramuscular injection of a recombinant adeno-associated Virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.
- Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in Chronic liver diseases? Interim results of a large case-control study.
- Genetic testing of minors for alpha1-antitrypsin deficiency.
- Cytotoxic concentrations of alpha-defensins in the Lungs of individuals with alpha 1-antitrypsin deficiency and moderate to severe Lung disease.
- Genetic testing for alpha1-antitrypsin deficiency.
- Z alpha1-antitrypsin polymerizes in the Lung and acts as a neutrophil chemoattractant.
- Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
- Role of human neutrophil peptides in Lung inflammation associated with alpha1-antitrypsin deficiency.
- Phase I trial of intramuscular injection of a recombinant adeno-associated Virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults.
- Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute Registry.
- Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency.
- Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies.
- Pharmacokinetic comparability of Prolastin(R)-C to Prolastin(R) in alpha(1)-antitrypsin deficiency: a randomized study.
- Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
- Quantitative airway assessment on computed tomography in patients with alpha1-antitrypsin deficiency.
- Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank.
- Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the Disease.
- Prevalence of alpha-1 antitrypsin deficiency in poorly controlled Asthma--results from the ALA-ACRC low-dose theophylline trial.
- Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
- Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice.
- Heritability of Lung function in severe alpha-1 antitrypsin deficiency.
- Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
- Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency.
- [American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency].
- Antibody response to aerosolized transgenic human alpha1-antitrypsin.
- Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes.
- Characterization of the molecular basis of the alpha 1-antitrypsin F allele.
- Molecular analysis of the heterogeneity among the P-family of alpha-1-antitrypsin alleles.
- Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern.
- Alpha 1-antitrypsin Wbethesda: molecular basis of an unusual alpha 1-antitrypsin deficiency variant.
- Characterization of the intracellular mechanism causing the alpha-1-antitrypsin Nullgranite falls deficiency state.
- Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing ...
- The alpha 1-antitrypsin gene and its mutations. Clinical consequences and strategies for therapy.
- Anti-neutrophil-elastase defenses of the lower Respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin.
- Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.
- Molecular basis of the liver and Lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
- Characterization of the coding sequence of the normal M4 alpha 1-antitrypsin gene.
- Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.
- Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.
- Repair of the secretion defect in the Z form of alpha 1-antitrypsin by addition of a second mutation.
- Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a re...
- alpha 1-Antitrypsin nullGranite Falls, a nonexpressing alpha 1-antitrypsin gene associated with a frameshift to stop mutation in a coding exon.
- Emphysema associated with complete absence of alpha 1- antitrypsin in serum and the homozygous inheritance [corrected] of a stop codon in an alpha 1-antitrypsin-coding...
- Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase.
- Characterization of the gene and protein of the alpha 1-antitrypsin "deficiency" allele Mprocida.
- Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with Pulmonary symptoms.
- Molecular basis of alpha-1-antitrypsin deficiency.
- Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes.
- Alpha 1-antitrypsin deficiency and Emphysema caused by homozygous inheritance of non-expressing alpha 1-antitrypsin genes.
- Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.
- Evaluation of tamoxifen as a therapy to augment alpha-1-antitrypsin concentrations in Z homozygous alpha-1-antitrypsin-deficient subjects.
- Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblast growth.
- Heparin as a pharmacologic intervention to induce positive scintiscan in occult gastrointestinal bleeding.
- Heterozygosity for an exon 12 splicing mutation and a W234G missense mutation in an American child with Chronic tyrosinemia type 1.
- Is rotaVirus a population of reassortants?
- Clinical features and molecular characteristics of alpha 1-antitrypsin deficiency.
- Metallothionein synthesis and degradation in Indian childhood cirrhosis fibroblasts.
- Characterization of a human alpha 1-antitrypsin null allele involving aberrant mRNA splicing.
- Genetic diversity from a limited repertoire of mutations on different common allelic backgrounds: alpha 1-antitrypsin deficiency variant Pduarte.
- Abnormal synthesis of dolichol-linked oligosaccharides in carbohydrate-deficient glycoprotein syndrome.
- Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I.
- Clinical features of individuals with PI*SZ phenotype of alpha 1-antitrypsin deficiency. alpha 1-Antitrypsin Deficiency Registry Study Group.
- Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of alpha 1-antitrypsin deficiency. Alpha 1-Antitrypsin Deficiency Regist...
- alpha1-antitrypsin gene mutation hot spot associated with the formation of a retained and degraded null variant [corrected; erratum to be published].
- Rapid development of hepatic alpha1-antitrypsin globules after liver transplantation for Chronic hepatitis C.
- Genetic defects and clinical characteristics of patients with a form of oculocutaneous albinism (Hermansky-Pudlak syndrome).
- Alpha 1-antitrypsin nonsense mutation associated with a retained truncated protein and reduced mRNA.
- Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency.
- Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated Virus vectors.
- Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors.
- Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of Emphysema in alpha1-antitrypsin deficiency.
- Pulmonary function and high-resolution CT findings in patients with an inherited form of Pulmonary fibrosis, Hermansky-Pudlak syndrome, due to mutations in HPS-1.
- Molecular mechanisms of alpha1-antitrypsin null alleles.
- Formation and current results of a patient-organized registry for alpha(1)-antitrypsin deficiency.
- Inhibition of recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from Cystic fibrosis patients.
- Pulmonary dysfunction in adults with nephropathic cystinosis.
- Biochemical efficacy and safety of a new pooled human plasma alpha(1)-antitrypsin, Respitin.
- Effect of pirfenidone on the Pulmonary fibrosis of Hermansky-Pudlak syndrome.
- Hermansky-Pudlak syndrome: radiography and CT of the chest compared with Pulmonary function tests and genetic studies.
- Alpha1-antitrypsin: not just an antiprotease: extending the half-life of a natural anti-inflammatory molecule by conjugation with polyethylene glycol.
- In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated Virus vectors expressing siRNA.
- Efficient and accurate approaches to the laboratory diagnosis of alpha1-antitrypsin deficiency: The promise of early diagnosis and intervention.
Schools
University Of Florida
Eastern Va Med School
Procedures Preformed
- Bronchoscopy
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Asthma
- Atelectasis
- Bronchiectasis
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Doctors Specialties
- Pulmonology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Eastern Virginia Medical School -
University of Florida College of Medicine
Hospital
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UF Health Shands Hospital
Drug Facts
| NPI NUMBER | 1619918646 | |
| NPPES Provider LastName | BRANTLY | |
| NPPES Provider FirstName | MARK | |
| NPPES Provider ZIPCode | 326103003 | |
| NPPES Provider State | FL | |
| Specialty Description | Pulmonary Disease | |
| Total Claim Count | 188.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1619918646 |
| Last Name Of The Provider | BRANTLY |
| First Name Of The Provider | MARK |
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