Professor, Radiation Oncology, University of Washington School of Medicine
Radiology
Dr. Mark T. Groudine, MD
Mark Groudine works in the field of Radiology. He has 1 awards "Whos Who in Medicine and Healthcare". Mark Groudine is a published physician as well. He has 100 publications published. The latest was: Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region.
Publications
- Something Silent This Way Forms: The Functional Organization of the Nuclear Repressive Compartment.
- UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions.
- An expansive human regulatory lexicon encoded in transcription factor footprints.
- An encyclopedia of mouse DNA elements (Mouse ENCODE).
- What can systems theory of networks offer to biology?
- The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.
- Cohesin Mediates Chromatin Interactions That Regulate Mammalian {beta}-globin Expression.
- Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.
- Dynamics and control of state-dependent networks for probing genomic organization.
- A functional element necessary for fetal hemoglobin silencing.
- Form follows function: The genomic organization of cellular differentiation.
- The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.
- The human beta-globin replication initiation region consists of two modular independent replicators.
- Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.
- Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics.
- On emerging nuclear order.
- Functional and mechanistic diversity of distal transcription enhancers.
- Networking the nucleus.
- Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
- Getting connected in the globin interactome.
- Enhancers: the abundance and function of regulatory sequences beyond promoters.
- Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
- Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.
- Developmental and species-divergent globin switching are driven by BCL11A.
- The nucleus inside out--through a rod darkly.
- The emergence of lineage-specific chromosomal topologies from coordinate gene regulation.
- Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells.
- H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription.
- Coordinate gene regulation during hematopoiesis is related to genomic organization.
- Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
- An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.
- Transcriptional interference among the murine beta-like globin genes.
- The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation.
- Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription.
- Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.
- Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.
- DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states.
- Gene order and dynamic domains.
- Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells.
- A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements.
- A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus.
- The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.
- Chromatin insulation by a transcriptional activator.
- Controlling the double helix.
- Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells.
- Fast neutron teletherapy for advanced carcinomas of the oral cavity and soft palate.
- Fast neutron teletherapy for advanced carcinomas of the oropharynx.
- Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.
- Fast neutron teletherapy for advanced carcinoma of hypopharynx and supraglottic larynx.
- Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis.
- TRAPping enhancer function.
- DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation.
- Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing.
- The undiscovered country: chromosome territories and the organization of transcription.
- ChIPs of the beta-globin locus: unraveling gene regulation within an active domain.
- Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions.
- Targeting silence: the use of site-specific recombination to introduce in vitro methylated DNA into the genome.
- Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation.
- Nuclear relocation of a transactivator subunit precedes target gene activation.
- Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites.
- The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.
- C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?
- Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter.
- Vitamin D(3) enhances the expression of I-mfa, an inhibitor of the MyoD family, in osteoblasts.
- The control of mammalian DNA replication: a brief history of space and timing.
- Nuclear compartmentalization and gene activity.
- Inhibition of Tcf3 binding by I-mfa domain proteins.
- Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.
- Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation.
- Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region.
- Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.
- Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.
- Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus.
- Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression.
- Dynamic analysis of proviral induction and De Novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcri...
- A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin.
- Looping versus linking: toward a model for long-distance gene activation.
- Analysis of mammalian cis-regulatory DNA elements by homologous recombination.
- Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.
- Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region.
- Long-distance transcriptional enhancement by the histone acetyltransferase PCAF.
- The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.
- Requirement of the mouse I-mfa gene for placental development and skeletal patterning.
- The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes.
- Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3'' enhancer.
- The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.
- Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3.
- Cell cycle perturbations in acute myeloid leukemia samples following in vitro exposures to therapeutic agents.
- DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs.
- The CDKN2A tumor-suppressor locus--a tale of two proteins.
- Deregulation of cell cycle control in hematologic malignancies.
- A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.
- Tumour-suppressor genes. Killer in search of a motive?
- Cyclin E-CDK2 is a regulator of p27Kip1.
- Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.
- Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines.
- Measurement of spontaneous and therapeutic agent-induced apoptosis with BCL-2 protein expression in acute myeloid leukemia.
- An upstream activator of transcription coordinately increases the level and epigenetic stability of gene expression.
- I-mf, a novel myogenic repressor, interacts with members of the MyoD family.
Schools
Perelman School of Medicine University of Pennsylvania
University Wa Med Center
Doctors Specialties
- Radiology
Accepted Insurances
Awards
- Whos Who in Medicine and Healthcare
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