Physician
Pediatric Hematology & Oncology
Dr. Matthew H. Porteus, MD
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Matthew Porteus works in the field of Pediatric Hematology & Oncology. He studied medicine at Stanford University School of Medicine. Stanford University School of Medicine is one of the top medical schools in the US. Stanford University School of Medicine is ranked 2 in research and 25 in primary care medicine Matthew Porteus is a published doctor and has 62 publications published. The lastest was: 'Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus.'
Publications
- Improved outcomes after autologous bone marrow transplantation for children with relapsed or refractory Hodgkin Lymphoma: twenty years experience at a single institution.
- Quantifying on- and off-target genome editing.
- Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.
- Genome Editing of Mouse Fibroblasts by Homologous Recombination for Sustained Secretion of PDGF-B and Augmentation of Wound Healing.
- Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing.
- SAPTA: a new design tool for improving TALE nuclease activity.
- Nuclease-mediated gene editing by homologous recombination of the human globin locus.
- An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level.
- A Crisper Look at Genome Editing: RNA-guided Genome Modification.
- A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered ade...
- Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases.
- Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs.
- Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells.
- Creating higher titer lentivirus with caffeine.
- MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.
- Gene correction by homologous recombination with zinc finger nucleases in primary cells from a mouse model of a generic recessive genetic disease.
- Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.
- Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels.
- Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation.
- Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
- Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.
- A look to future directions in gene therapy research for monogenic diseases.
- Mammalian gene targeting with designed zinc finger nucleases.
- Gene targeting using zinc finger nucleases.
- Chimeric nucleases stimulate gene targeting in human cells.
- Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks.
- Strategies to increase genome editing frequencies and to facilitate the identification of edited cells.
- Genome editing in mouse spermatogonial stem/progenitor cells using engineered nucleases.
- Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.
- Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification.
- Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus.
- Characteristics and outcome of children with Beckwith-Wiedemann syndrome and Wilms' tumor: a report from the National Wilms Tumor Study Group.
- Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus.
- The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos.
- DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain.
- Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segme...
- The spatial localization of Dlx-2 during tooth development.
- Coccidioidal antigen reactive CD4+ T-lymphocytes in the cerebrospinal fluid in coccidioides immitis meningitis.
- Subtractive hybridization system using single-stranded phagemids with directional inserts.
- Deletion of chromosome 1p: a short review.
- Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain.
- A partial cDNA sequence of the Dlx-2 cDNA.
- Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon.
- DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2.
- Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
- Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells.
- Highly efficient endogenous human gene correction using designed zinc-finger nucleases.
- Using homologous recombination to manipulate the genome of human somatic cells.
- Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.
- Plant biotechnology: Zinc fingers on target.
- Design and testing of zinc finger nucleases for use in mammalian cells.
- Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair.
- Zinc fingers hit off target.
- Seeing the light: integrating genome engineering with double-strand break repair.
- Translating the lessons from gene therapy to the development of regenerative medicine.
- Creating zinc finger nucleases to manipulate the genome in a site-specific manner using a modular-assembly approach.
- Testing a three-finger zinc finger nuclease using a GFP reporter system.
- Creating zinc finger nucleases using a modular-assembly approach.
- Benefits of utilizing gene-modified iPSCs for clinical applications.
- Homologous recombination-based gene therapy for the primary immunodeficiencies.
- Gene editing: not just for translation anymore.
Schools
Stanford University School Of Medicine
Children39s Hospital Boston
Chldns Hospital Dana Farber Canc Institute
Conditions Treated
- Acute Leukemia
- Lymphoma
- Mycosis Fungoides
- Myeloproliferative Disorders
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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Boston Children's Hospital -
Stanford University School of Medicine
Hospital
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Lucile Packard Children's Hospital Stanford -
Stanford Health Care
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