Physician

Cardiology

Michael Pack works in the field of Cardiology. He over the years received 2 awards: "Meaningful Use Stage 1 Certification" and "Fellow (FACC)". Michael Pack is also published. He has 36 publications published. The lastest publication: "Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells.'

Publications

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• Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1).
• Zebrafish models of human liver development and Disease.
• CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
• Decreased levels of the RNA splicing factor Prpf3 in mice and zebrafish do not cause photoreceptor degeneration.
• Analysis of the zebrafish proteome during embryonic development.
• Prostaglandin E synthases in zebrafish.
• Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.
• Developmental expression of functional cyclooxygenases in zebrafish.
• p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis.
• Analysis of small molecule metabolism in zebrafish.
• Genetic analysis of digestive physiology using fluorescent phospholipid reporters.
• Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish.
• Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells.
• Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.
• Zebrafish as a model for pancreatic cancer research.
• Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine.
• Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers Syndrome.
• Intestinal growth and differentiation in zebrafish.
• Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.
• The nuclear pore complex protein elys is required for genome stability in mouse intestinal epithelial progenitor cells.
• Transgenic labeling of the zebrafish pronephric duct and tubules using a promoter from the enpep gene.
• Characterization of zebrafish intestinal smooth muscle development using a novel sm22?-b promoter.
• Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis Syndrome, regulates biliary development downstream of the ...
• Reiterative use of the notch signal during zebrafish intrahepatic biliary development.
• Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins.
• Zebrafish hhex regulates liver development and digestive organ chirality.
• Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine.
• Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.
• Unique and conserved aspects of gut development in zebrafish.
• The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development.
• Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille Syndrome phenocopy.
• Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell.
• TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
• Exocrine pancreas development in zebrafish.
• Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.

Schools

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• KS UNIV OF MED amp BIOSCI COLL OF OSTEO MED

Procedures Preformed

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• Ablation for Treatment of Cardiac Arrhythmias
• Cardiac Catheterization (incl. Coronary Angiography)
• Cardiac Imaging
• Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
• View All

Conditions Treated

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• Aneurysm and Dissection of Heart
• Angina and Acute Coronary Syndrome
• Aortic Aneurysm
• Aortic Dissection
• View All

Doctors Specialties

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• Cardiology

Accepted Insurances

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Awards

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• Meaningful Use Stage 1 Certification
• Fellow (FACC)

Education

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• University of Arizona
• Kansas City University of Medicine and Biosciences

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