Professor, Pathology, UCSD School of Medicine
Pathology
Dr. Michael J. Kelner, MD
|
|
Give Review
Michael Kelner practices Pathology. He attended University of Minnesota Medical School. University of Minnesota Medical School is ranked 40 in research and 10 in primary care medicine Michael Kelner is a published doctor as well. He has 73 publications published. The latest was: Metabolism of antitumor acylfulvene by rat liver cytosol. Michael J. Kelner is registered with Medicare and accepts Medicare payments.
Publications
- Hydroxyurea derivatives of irofulven with improved antitumor efficacy.
- A rare and unique case of aggressive IgE-λ plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass.
- Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
- Stability of levothyroxine sodium 0.4 microg/mL in 0.9% sodium chloride injection.
- Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with g...
- Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.
- Phase I/II study of continuous-infusion troxacitabine in refractory acute myeloid leukemia.
- Synthesis and biological activity of enantiomers of antitumor irofulven.
- Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.
- Reaction of irofulven with zinc and acid.
- Sesquiterpenes from Omphalotus illudens.
- Enhanced antitumor activity of irofulven in combination with antimitotic agents.
- Design and Synthesis of Antitumor Acylfulvenes.
- Oxidation of glutathione by methylene blue is equivalent in G-6-PD deficient and normal erythrocytes.
- Inhibition of erythrocyte superoxide dismutase by diethyldithiocarbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production.
- Methylene blue directly oxidizes glutathione without the intermediate formation of hydrogen peroxide.
- PDGF-induces the glutathione-dependent enzyme PGH2/PGE2 isomerase in NIH3T3 and pEJ transformed fibroblasts.
- Mechanism of prostaglandin E2 release and increase in PGH2/PGE2 isomerase activity by PDGF: involvement of nitric oxide.
- Newer cardiac agents: antiarrhythmics and antianginal agents.
- Definitive liquid-chromatographic demonstration that N-ethylglycine is the metabolite of lidocaine that interferes in the Kodak sarcosine oxidase-coupled method for cr...
- The effect of gamma hydroxybutyrate on serum osmolality.
- Transfection with human copper-zinc superoxide dismutase induces bidirectional alterations in other antioxidant enzymes, proteins, growth factor response, and paraquat...
- Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat...
- Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen...
- Superoxide dismutase abolishes the platelet-derived growth factor-induced release of prostaglandin E2 by blocking induction of nitric oxide synthase: role of superoxide.
- Heterologous expression of selenium-dependent glutathione peroxidase affords cellular resistance to paraquat.
- Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.
- Glutathione-dependent enzymes alone can produce paraquat resistance.
- Inactivation of intracellular copper-zinc superoxide dismutase by copper chelating agents without glutathione depletion and methemoglobin formation.
- Potential of methylene blue to block oxygen radical generation in reperfusion injury.
- Methylene blue competes with paraquat for reduction by flavo-enzymes resulting in decreased superoxide production in the presence of heme proteins.
- Paraquat resistance associated with reduced NADPH reductase in an energy-dependent paraquat-accumulating cell line.
- Heterologous expression of carbonyl reductase: demonstration of prostaglandin 9-ketoreductase activity and paraquat resistance.
- Preclinical evaluation of illudins as anticancer agents.
- Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S.
- Distribution of microsomal glutathione transferase 1 in mammalian tissues. A predominant alternate first exon in human tissues.
- HPLC determination of a new anticancer agent (acylfulvene) in serum.
- Thioureas react with superoxide radicals to yield a sulfhydryl compound. Explanation for protective effect against paraquat.
- Alteration of growth rate and fibronectin by imbalances in superoxide dismutase and glutathione peroxidase activity.
- Structural organization of the human microsomal glutathione S-transferase gene (GST12).
- Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence.
- Metabolism of antitumor hydroxymethylacylfulvene by rat liver cytosol.
- Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan.
- In vitro and in vivo studies on the anticancer activity of dehydroilludin M.
- Preclinical evaluation of illudins as anticancer agents: basis for selective cytotoxicity.
- Metabolism of antitumor acylfulvene by rat liver cytosol.
- On the mechanism of toxicity of illudins: the role of glutathione.
- Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants i...
- Nonresponsiveness of the metastatic human lung carcinoma MV522 xenograft to conventional anticancer agents.
- Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft.
- Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3''-nontranscribed region: transcriptional response to exogenous redox...
- Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstr...
- Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines.
- Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft.
- Acylfulvenes, a new class of potent antitumor agents.
- Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity aga...
- Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxid...
- Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells.
- Characterization of acylfulvene histiospecific toxicity in human tumor cell lines.
- Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents.
- (Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
- Sesquiterpenes from the basidiomycete Omphalotus illudens.
- Preparation and biological activity of amino acid and peptide conjugates of antitumor hydroxymethylacylfulvene.
- Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues.
- Preparation of crotaline F-ab antivenom (CroFab) with automated mixing methods: in vitro observations.
- CroFab reconstitution in various media: an in vitro solubility study.
- Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehens...
- Synthesis and antitumor activity of amine analogs of irofulven.
- Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung...
- Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pa...
- Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3.
- Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.
Schools
University of Mn Med Sch
San Francisco General Hospital
University Calif
Doctors Specialties
- Chemical Pathology
- Pathology
Accepted Insurances
Education
-
University of California San Diego -
University of Minnesota Medical School
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1174679849 |
| Last Name Of The Provider | KELNER |
| First Name Of The Provider | MICHAEL |
| View All |
Similar Doctors
|
|
Dr. David N. Bailey, MD |
|
|
Dr. Slawomir T. Niewiadomski, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Seong H. Ra, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Julia Phillipson, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Noel Weidner, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Raymond H. Summers II, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. David A. Herold, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amadeo Pesce, PHD |