Physician

Endocrinology

Dr. Michael Kaleko, MD

Dr. Michael Kaleko is an expert in the field of Endocrinology. Michael Kaleko is a published doctor and has 56 publications published. The lastest was: 'Haemophilia A gene therapy.'

Publications

Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression.
Adenovirus-mediated factor VIII gene expression results in attenuated anti-factor VIII-specific immunity in hemophilia A mice compared with factor VIII protein infusion.
Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.
Generation and characterization of E1/E2a/E3/E4-deficient adenoviral vectors encoding human factor VIII.
Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity i...
In vivo dose threshold effect of adenovirus-mediated factor VIII gene therapy in hemophiliac mice.
Adenoviral vector-mediated expression of physiologic levels of human factor VIII in nonhuman primates.
In vivo evaluation of a novel epitope-tagged human factor VIII-encoding adenoviral vector.
In vivo evaluation of an adenoviral vector encoding canine factor VIII: high-level, sustained expression in hemophiliac mice.
Efficient adenoviral vector transduction and expression of functional human factor VIII in cultured primary human hepatocytes.
Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.
Evaluation of an adenoviral vector encoding full-length human factor VIII in hemophiliac mice.
Haemophilia A gene therapy.
Circumvention of immunity to the adenovirus major coat protein hexon.
Multivalent cations and ligand affinity of the type 1 insulin-like growth factor receptor on P2A2-LISN muscle cells.
An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene.
Sustained phenotypic correction of murine hemophilia A by in vivo gene therapy.
Gene therapy for hemophilia A.
Complete short-term correction of canine hemophilia A by in vivo gene therapy.
Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector.
High-level tissue-specific expression of functional human factor VIII in mice.
Sustained expression of therapeutic levels of human factor VIII in mice.
Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice.
Type-1 insulin-like growth factor receptor overexpression produces dual effects on myoblast proliferation and differentiation.
Ligand-dependent inhibition of myoblast differentiation by overexpression of the type-1 insulin-like growth factor receptor.
In vivo gene delivery and expression of physiological levels of functional human factor VIII in mice.
c phosphorylation and activation of the IGF-I receptor in src-transformed cells.
Membrane sites regulating developmental gene expression in Dictyostelium discoideum.
Design of retrovirus vectors for transfer and expression of the human beta-globin gene.
Expression of human adenosine deaminase in mice after transplantation of genetically-modified bone marrow.
Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.
Long-term expression of human adenosine deaminase in mice after transplantation of bone marrow infected with amphotropic retroviral vectors.
Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency...
Persistent gene expression after retroviral gene transfer into liver cells in vivo.
Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor.
Synthesis of adenoviral targeting molecules by intein-mediated protein ligation.
Complete sequence and organization of the human adenovirus serotype 46 genome.
Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization.
A synthetic Rev-independent bovine immunodeficiency virus-based packaging construct.
Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor.
Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization.
Potentiation of oncolytic adenoviral vector efficacy with gutless vectors encoding GMCSF or TRAIL.
Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates.
Development of adenovirus serotype 35 as a gene transfer vector.
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice.
In vivo ligand-inducible regulation of gene expression in a gutless adenoviral vector system.
Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment.
Optimization of the generation and propagation of gutless adenoviral vectors.
Mapping of the bovine immunodeficiency virus packaging signal and RRE and incorporation into a minimal gene transfer vector.
Evaluation of the duration of human factor VIII expression in nonhuman primates after systemic delivery of an adenoviral vector.
Sustained transduction of ocular cells with a bovine immunodeficiency viral vector.
Development of second- and third-generation bovine immunodeficiency virus-based gene transfer systems.
In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor.
Targeting adenoviral vectors by using the extracellular domain of the coxsackie-adenovirus receptor: improved potency via trimerization.
Sustained human factor VIII expression in hemophilia A mice following systemic delivery of a gutless adenoviral vector.

Schools

Brown University Alpert Medical School

Doctors Specialties

Internal Medicine
Endocrinology

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