Professor, Medicine, University of Maryland School of Medicine

Infectious Disease

Michael Donnenberg works in the field of Infectious Disease. He studied medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical college. Columbia University College of Physicians & Surgeons is ranked 8/52 in Research/PrimaryCare. He over the years received 11 awards: "Student Council Pre-clinical Faculty Award", "Student Selected Faculty Address", "Inaugural Class, Carolyn J. Pass, MD 66 and Richard J. Susel, MD 66 Academy of Educational Excellence", "Fellow", "Host Defenses and Infectious Diseases Teaching Commendation, Virology", "First annual Jacob Francisco Lectureship", "Host Defenses and Infectious Diseases Teaching Commendation, Bacteriology", "Elected Member", "Oswald Avery Award", "Scholarship in Medicine" and "Dean's Research Fellowship". Dr. Michael S. Donnenberg is a published doctor and has 99 publications published. The lastest was: 'Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology.'

Publications

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• Diarrhea, bacteremia and multiorgan dysfunction due to an extraintestinal pathogenic Escherichia coli strain with enteropathogenic E. coli genes.
• Signature-tagged Mutagenesis and Co-infection Studies Demonstrate the Importance of P fimbriae in a Murine Model of Urinary Tract Infection.
• Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile.
• Enteropathogenic Escherichia coli Inhibits Type I Interferon- and RNase L-Mediated Host Defense To Disrupt Intestinal Epithelial Cell Barrier Function.
• Identification, immunogenicity, and cross-reactivity of type IV pilin and pilin-like proteins from Clostridium difficile.
• Structure of Clostridium difficile PilJ Exhibits Unprecedented Divergence from Known Type IV Pilins.
• Uncomplicated cystitis--not so simple.
• How to diagnose a foodborne illness.
• Combating enteropathogenic Escherichia coli (EPEC) infections: the way forward.
• Refining the pathovar paradigm via phylogenomics of the attaching and effacing Escherichia coli.
• BfpL is Essential for Type IV Bundle-forming Pilus Biogenesis and Interacts with the Periplasmic Face of BfpC.
• Outer Membrane Targeting, Ultrastructure and Single Molecule Localization of the Enteropathogenic Escherichia coli Type IV Pilus Secretin BfpB.
• THE N-TERMINAL AMPHIPATHIC REGION OF THE ESCHERICHIA COLI TYPE III SECRETION SYSTEM PROTEIN EspD IS REQUIRED FOR MEMBRANE INSERTION AND FUNCTION.
• Bundle forming pilus retraction enhances enteropathogenic Escherichia. coli infectivity.
• Interactions and Predicted Host Membrane Topology of Enteropathogenic Escherichia coli Translocator Protein EspB.
• A novel approach to investigate the uptake and internalization of Escherichia coli O157:H7 in spinach cultivated in soil and hydroponic medium.
• Role of the K2 capsule in Escherichia coli urinary tract infection and serum resistance.
• Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans.
• Encephalitis of the basal ganglia in an injection drug user.
• Functional consequences of sequence variation in bundlin, the enteropathogenic Escherichia coli type IV pilin protein.
• The type IV pilin of Burkholderia mallei is highly immunogenic but fails to protect against lethal aerosol challenge in a murine model.
• Molecular evolution of typical enteropathogenic Escherichia coli: clonal analysis by multilocus sequence typing and virulence gene allelic profiling.
• Analysis of the function of enteropathogenic Escherichia coli EspB by random mutagenesis.
• Structure of the bundle-forming pilus from enteropathogenic Escherichia coli.
• Citrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo.
• Transcriptome of uropathogenic Escherichia coli during urinary tract infection.
• Identification and characterization of a novel uropathogenic Escherichia coli-associated fimbrial gene cluster.
• Enteropathogenic Escherichia coli O157 strains from Brazil.
• A gene from the locus of enterocyte effacement that is required for enteropathogenic Escherichia coli to increase tight-junction permeability encodes a chaperone for E...
• A cluster of fourteen genes from enteropathogenic Escherichia coli is sufficient for the biogenesis of a type IV pilus.
• Entry of enteropathogenic Escherichia coli into host cells.
• Attaching and effacing of host cells by enteropathogenic Escherichia coli in the absence of detectable tyrosine kinase mediated signal transduction.
• DsbA is required for stability of the type IV pilin of enteropathogenic escherichia coli.
• Products of enteropathogenic E. coli inhibit lymphokine production by gastrointestinal lymphocytes.
• The locus of enterocyte effacement pathogenicity island of enteropathogenic Escherichia coli encodes secretion functions and remnants of transposons at its extreme rig...
• Interactions between enteropathogenic Escherichia coli and host epithelial cells.
• A third secreted protein that is encoded by the enteropathogenic Escherichia coli pathogenicity island is required for transduction of signals and for attaching and ef...
• Internalization of Escherichia coli by human renal epithelial cells is associated with tyrosine phosphorylation of specific host cell proteins.
• Biogenesis of the bundle-forming pilus of enteropathogenic Escherichia coli: reconstitution of fimbriae in recombinant E. coli and role of DsbA in pilin stability--a r...
• Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge.
• Role of BfpF, a member of the PilT family of putative nucleotide-binding proteins, in type IV pilus biogenesis and in interactions between enteropathogenic Escherichia...
• The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69.
• Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7.
• A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway.
• The EspB protein of enteropathogenic Escherichia coli is targeted to the cytoplasm of infected HeLa cells.
• Enteropathogenic Escherichia coli virulence genes encoding secreted signalling proteins are essential for modulation of Caco-2 cell electrolyte transport.
• Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology.
• Interactions between enteropathogenic Escherichia coli and epithelial cells.
• The Per regulon of enteropathogenic Escherichia coli : identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement...
• The type IV bundle-forming pilus of enteropathogenic Escherichia coli undergoes dramatic alterations in structure associated with bacterial adherence, aggregation and ...
• Salmonella strikes a balance.
• Arcanum: The 19th-century Italian pharmacist pictured here was the first to characterize what are now known to be bacteria of the genus Serratia.
• A large toxin from pathogenic Escherichia coli strains that inhibits lymphocyte activation.
• Evidence for specificity in type 4 pilus biogenesis by enteropathogenic Escherichia coli.
• Effects of bfp mutations on biogenesis of functional enteropathogenic Escherichia coli type IV pili.
• The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection.
• The sound that failed.
• Role of EspB in experimental human enteropathogenic Escherichia coli infection.
• Pathogenic strategies of enteric bacteria.
• Molecular variation among type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coli strains.
• The role of pyridoxal phosphate in the function of EspB, a protein secreted by enteropathogenic Escherichia coli.
• Identification of putative urovirulence genes by subtractive cloning.
• Pathogenesis and evolution of virulence in enteropathogenic and enterohemorrhagic Escherichia coli.
• Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function.
• Role of EspF in host cell death induced by enteropathogenic Escherichia coli.
• Novel topology of BfpE, a cytoplasmic membrane protein required for type IV fimbrial biogenesis in enteropathogenic Escherichia coli.
• BfpU, a soluble protein essential for type IV pilus biogenesis in enteropathogenic Escherichia coli.
• Adhesion of enteropathogenic Escherichia coli to host cells.
• Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin.
• The inner membrane subassembly of the enteropathogenic Escherichia coli bundle-forming pilus machine.
• SepL, a protein required for enteropathogenic Escherichia coli type III translocation, interacts with secretion component SepD.
• Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway.
• Interaction and localization studies of enteropathogenic Escherichia coli type IV bundle-forming pilus outer membrane components.
• Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2.
• PhoU enhances the ability of extraintestinal pathogenic Escherichia coli strain CFT073 to colonize the murine urinary tract.
• The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus.
• N-acetyllactosamine-induced retraction of bundle-forming pili regulates virulence-associated gene expression in enteropathogenic Escherichia coli.
• The bundlin pilin protein of enteropathogenic Escherichia coli is an N-acetyllactosamine-specific lectin.
• Rapid site-directed domain scanning mutagenesis of enteropathogenic Escherichia coli espD.
• From alpha to beta: identification of amino acids required for the N-acetyllactosamine-specific lectin-like activity of bundlin.
• Type IV Pilus Secretins Have Extracellular C Termini.
• Draft Genome Sequences of Three O157 Enteropathogenic Escherichia coli Isolates.
• Allelic variability of critical virulence genes (eae, bfpA and perA) in typical and atypical enteropathogenic Escherichia coli in Peruvian children.
• Complete resonance assignments of bundlin (BfpA) from the bundle-forming pilus of enteropathogenic Escherichia coli.
• Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.
• Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.
• A plasmid-encoded type IV fimbrial gene of enteropathogenic Escherichia coli associated with localized adherence.
• Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cyto...
• Enteropathogenic Escherichia coli.
• Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells.
• Infections due to Stomatococcus mucilaginosus: report of two new cases and review.
• Borrelia burgdorferi in the central nervous system.
• Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector.
• Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells.
• A comparison of HEp-2 cell invasion by enteropathogenic and enteroinvasive Escherichia coli.
• Epithelial cell invasion: an overlooked property of enteropathogenic Escherichia coli (EPEC) associated with the EPEC adherence factor.
• Methods for studying adhesion of diarrheagenic Escherichia coli.
• The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection.

Schools

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• Columbia University College of Physicians And Surgeons

• Baltimore City Hospital

• Francis Scott Key Center

• New Eng Med Center

Doctors Specialties

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• Infectious Disease Medicine
• Infectious Disease

Accepted Insurances

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Awards

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• Student Council Pre-clinical Faculty Award
• Student Selected Faculty Address
• Inaugural Class, Carolyn J. Pass, MD ‘66 and Richard J. Susel, MD ’66 Academy of Educational Excellence
• Fellow
• Host Defenses and Infectious Diseases Teaching Commendation, Virology
• First annual Jacob Francisco Lectureship
• Host Defenses and Infectious Diseases Teaching Commendation, Bacteriology
• Elected Member
• Oswald Avery Award
• Scholarship in Medicine
• Dean's Research Fellowship

Education

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• Tufts Medical Center
• Johns Hopkins Bayview Medical Center
• Columbia University College of Physicians & Surgeons
• State University of New York

Hospital

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• University of Maryland Medical Center

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