Physician
Neurology
Dr. Miguel A. Pappolla, MD
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Miguel Pappolla practices Neurology. He over the years received 9 awards: "CMS Meaningful Use Stage 1 Certification", "Josephine T. Morse Endowed Professorship in Neuropathology", "Commendation Award for Academic Excellence and Leadership", "Teaching Award, Department of Neurology.", "Weil Award (awarded to the best study in Neuropathology leading to advancements on mechanisms of disease).", "Zenith Fellowship Award ($250,000)", "James A. Shannon Directors Award, ($100,000)", "Commendation Award, for Academic and Clinical Excellence" and "Honorary Member Emeritus". Miguel Pappolla is a published doctor. He published 92 publications, including: 'Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain.' Miguel A. Pappolla accepts Medicare payments and is registered with Medicare.gov.
Publications
- Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer's Disease.
- Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.
- Higher incidence of mild cognitive Impairment in familial hypercholesterolemia.
- A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan.
- Insulysin cleaves the APP cytoplasmic fragment at multiple sites.
- Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues.
- Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
- Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents.
- Melatonin relieves the neural oxidative burden that contributes to dementias.
- Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).
- Development of indole-3-propionic acid (OXIGON) for Alzheimer's Disease.
- Cholesterol, oxidative stress, and Alzheimer's Disease: expanding the horizons of pathogenesis.
- Oxidative Stress and the Amyloid Conundrum. What is the Connection?
- Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease.
- A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene.
- Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology.
- Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
- Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's Disease brain.
- A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's Disease.
- Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
- Soluble complement receptor 1 (sCR1) is not as effective as cobra venom factor in the treatment of experimental allergic neuritis.
- Systemic complement depletion reduces inflammation and demyelination in adoptive transfer experimental allergic neuritis.
- Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a Chronic oxidative paradigm for testing ant...
- Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
- Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain.
- RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's Disease.
- Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid.
- Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin.
- An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer''s Disease.
- Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
- Neuronal oxidative stress precedes amyloid-beta deposition in Down Syndrome.
- Amyloid deposition in diffuse plaques may or may not start at the neuronal cell surface membrane.
- Colloid (hyaline) inclusion bodies in the central nervous system: their presence in the substantia nigra is diagnostic of Parkinson's Disease.
- Serum protein leakage in aged human brain and inhibition of ligand binding at alpha 2-adrenergic and cholinergic binding sites.
- Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein.
- The "normal" brain. "Abnormal" ubiquitinilated deposits highlight an age-related protein change.
- Serum protein interactions with neurotransmitter receptors: implications for Alzheimer's Disease.
- Concurrent neuroborreliosis and Alzheimer's Disease: analysis of the evidence.
- Image analysis microspectroscopy of senile plaque capillary amyloid in Alzheimer's Disease. A preliminary study.
- Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain.
- Lewy bodies of Parkinson's Disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments.
- Computerized image-analysis microspectroscopy of tissue sections.
- Neuronal aging.
- Primary plasmacytoma of the stomach.
- Histologic differentiation of gout and pseudogout using polarized light.
- PAS reaction stains phagocytosed atypical mycobacteria in paraffin sections.
- Identification of parasite eggs.
- The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment.
- Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's Disease.
- The genesis of the senile plaque. Further evidence in support of its neuronal origin.
- Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells.
- Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques.
- Two distinct types of intraneuronal neurofibrillary tangles highlighted by polarized light after silver impregnation with a modified Bielschowsky method.
- Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero.
- Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle.
- Bradykinin induces superoxide anion release from human endothelial cells.
- Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization.
- A confusing case of Miyoshi distal myopathy.
- Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins.
- Complement depletion affects demyelination and inflammation in experimental allergic neuritis.
- Oxygen-free radicals and amyloidosis in Alzheimer's Disease: is there a connection?
- Microscopic polyangiitis with ocular involvement.
- The heat shock/oxidative stress connection. Relevance to Alzheimer Disease.
- Oral administration of type I interferon modulates the course of experimental allergic neuritis.
- Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.
- Prophylactic actions of melatonin in oxidative neurotoxicity.
- The amyloid beta protein induces oxidative damage of mitochondrial DNA.
- Inhibition of Alzheimer beta-fibrillogenesis by melatonin.
- Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's Disease.
- Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: relevance to neuroDegenerative disease.
- Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size.
- Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver Disease.
- Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis.
- Reinduction of experimental autoimmune encephalomyelitis in mice.
- Alpha-spectrins are major ubiquitinated proteins in rat hippocampal neurons and components of ubiquitinated inclusions in neurodegenerative Disorders.
- The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
- Deficiency of chaperonin 60 in Down''s Syndrome.
- Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer''s Disease.
- Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.
- Statin therapy for Alzheimer's Disease: will it work?
- Alzheimer's Disease--a dysfunction in cholesterol and lipid metabolism.
- Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent.
- Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.
- Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.
- Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.
- Beta-secretase: structure, function, and evolution.
- Targets for AD treatment: conflicting messages from γ-secretase inhibitors.
- Frontiers in the pathogenesis of Alzheimer''s Disease.
- Differential accumulation of secreted AbetaPP metabolites in ocular fluids.
- Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer''s disease.
- Leptin and the skin: a new frontier.
Schools
Universidad De Buenos Aires Facultad De Ciencias Medicas
Case West Res University
Ne Ohio University Affil Hosps
Univ Of South Alabama Medical Center
Cleveland Clin Fdn
University Of Mississippi Medical Center
Procedures Preformed
- Cervical Block
- Cervical Epidural Steroid Injection
- EMG (Electromyography)
- Epidural Block
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Conditions Treated
- Back Disorders
- Back Impairment
- Back Injuries
- Back Pain
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Doctors Specialties
- Neurology
- Pain Medicine
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Amerigroup (Wellpoint)
- Blue Card PPO
- Blue Advantage HMO
- Blue Choice
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- WellCare
Awards
- CMS Meaningful Use Stage 1 Certification
- Josephine T. Morse Endowed Professorship in Neuropathology
- Commendation Award for Academic Excellence and Leadership
- Teaching Award, Department of Neurology.
- Weil Award (awarded to the best study in Neuropathology leading to advancements on mechanisms of disease).
- Zenith Fellowship Award ($250,000)
- James A. Shannon Director’s Award, ($100,000)
- Commendation Award, for Academic and Clinical Excellence
- Honorary Member Emeritus
Education
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University of Mississippi Medical Center -
University of South Alabama -
Cleveland Clinic Foundation -
Case Western Reserve University Affiliated Hospitals -
Case Western Reserve University -
University of Buenos Aires
Hospital
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Park Plaza Hospital
Drug Facts
| NPI NUMBER | 1528051646 | |
| NPPES Provider LastName | PAPPOLLA | |
| NPPES Provider FirstName | MIGUEL | |
| NPPES Provider ZIPCode | 770541901 | |
| NPPES Provider State | TX | |
| Specialty Description | Neurology | |
| Total Claim Count | 264.0 | |
| Distinct Opioid Count | 3.0 | |
| Opioid Claim Count | 36.0 | |
| Percent Opioid Claims | 13.64 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1528051646 |
| Last Name Of The Provider | PAPPOLLA |
| First Name Of The Provider | MIGUEL |
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