Director of Transplantation Research Center
Nephrology
Dr. Mohamed H. Sayegh, MD
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Doctor Mohamed H. Sayegh, MD is an expert in the field of Nephrology. He received awards:"Elected Member" and "Fellow (ASNF)". Mohamed H. Sayegh is a published physician. He published 101 publications, including: 'Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens.'
Publications
- Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens.
- TIM4 regulates the anti-islet Th2 alloimmune response.
- Role of Podocyte B7-1 in Diabetic Nephropathy.
- Targeting CD28 to prevent transplant rejection.
- Calcineurin Inhibitors: 40 Years Later, Can't Live Without ...
- T-cell co-stimulatory blockade in transplantation: two steps forward one step back!
- Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7.
- Effect of the Purinergic Inhibitor Oxidized-ATP in a Model of Islet Allograft Rejection.
- In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity.
- Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses.
- In memoriam: charles bernard carpenter.
- IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
- Inotuzumab Ozogamicin Murine Analog-Mediated B-Cell Depletion Reduces Anti-Islet Allo- and Autoimmune Responses.
- Immune profile of pediatric renal transplant recipients following alemtuzumab induction.
- The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance.
- Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection.
- Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.
- The Novel Role of SERPINB9 in Cytotoxic Protection of Human Mesenchymal Stem Cells.
- The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
- The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo.
- Costimulatory pathways in transplantation.
- Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.
- Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.
- Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.
- Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes.
- Chronic renal allograft dysfunction (CAD): new frontiers. Introduction.
- A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice.
- A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model.
- Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.
- A novel in vivo regulatory role of P-glycoprotein in alloimmunity.
- Transplant nephrectomy improves survival following a failed renal allograft.
- Clinical transplantation tolerance: a myth no more, but...
- Understanding how Tregs are regulated: therapeutic implications.
- Immunosuppressive drugs and Tregs: a critical evaluation!
- Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
- Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
- A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.
- Introduction: Nephrology Hall of Fame for CJASN.
- Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.
- Complement dances with T cells.
- Mechanisms underlying blockade of allograft acceptance by TLR ligands.
- Negative T-cell costimulatory pathways: their role in regulating alloimmune responses.
- Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
- Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells.
- Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes.
- Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells.
- Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.
- Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.
- Regulating rejection with cell therapy.
- Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.
- The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
- Allograft rejection mediated by memory T cells is resistant to regulation.
- Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.
- A link between PDL1 and T regulatory cells in fetomaternal tolerance.
- PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.
- Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
- Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.
- A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
- Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
- Clinical transplantation tolerance: many rivers to cross.
- Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic models.
- Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival.
- Maternal acceptance of the fetus: true human tolerance.
- New reagents on the horizon for immune tolerance.
- Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
- A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells.
- Costimulation couture: a designer approach to regulating autoimmunity.
- Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation.
- Tissue expression of PD-L1 mediates peripheral T cell tolerance.
- Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
- Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
- Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experi...
- Role of CXC chemokine receptor 3 pathway in renal ischemic injury.
- Critical, but conditional, role of OX40 in memory T cell-mediated rejection.
- Measuring T cell alloreactivity to predict kidney transplant outcomes: are we there yet?
- Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.
- Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
- Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
- Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine.
- T-cell costimulatory pathways in allograft rejection and tolerance.
- Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
- Matrix embedding alters the immune response against endothelial cells in vitro and in vivo.
- A critical role for the programmed death ligand 1 in fetomaternal tolerance.
- Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
- ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
- Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection.
- Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells.
- Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo.
- CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.
- Transplantation 50 years later--progress, challenges, and promises.
- TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.
- Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation.
- Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy.
- Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
- The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.
- Clinical transplantation tolerance: the promise and challenges.
- Overview: future approaches to renal replacement and regeneration.
- Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli.
- Regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway.
- Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.
Schools
American University Of Beirut Faculty Of Medicine
Cleveland Clinic
Brigham Womens Hospital
Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Elected Member
- Fellow (ASNF)
Education
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Brigham and Women's Hospital -
Cleveland Clinic Foundation -
American University of Beirut Faculty of Medicine
Hospital
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Brigham and Women's Hospital
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