Physician
Gastroenterology
Dr. Neil Kaplowitz, MD
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Doctor Neil Kaplowitz, MD is an expert in the field of Gastroenterology. He studied medicine at Albert Einstein College of Medicine at Jacobi Medical Center. He has 1 awards "Elected Member". Neil Kaplowitz is a published doctor. He has 101 publications published. The most current publication "Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus..."
Publications
- JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src.
- HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients With Cancer.
- Mechanisms of Adaptation and Progression in Idiosyncratic Drug Induced Liver Injury, Clinical Implications.
- Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database.
- Targeting Signal Transduction Pathways which Regulate Necrosis in Acetaminophen Hepatotoxicity.
- Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
- The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future.
- Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways.
- In Vitro Assays of Mitochondrial Function/Dysfunction.
- Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance.
- Asmase Regulates Autophagy and Lysosomal Membrane Permeabilization and its Inhibition Prevents Early Stage Nonalcoholic Steatohepatitis.
- Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway.
- Mechanisms of drug-induced liver injury.
- Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
- Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.
- Avoiding idiosyncratic DILI: Two is better than one.
- Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: Biogenesis, remodeling, and functional alterations.
- Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.
- The use of isolated perfused liver in studies of biological transport processes.
- Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ.
- Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver.
- Hormonal regulation of glutathione efflux.
- Importance and regulation of hepatic glutathione.
- The use of monochlorobimane to determine hepatic GSH levels and synthesis.
- Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin.
- Calcium compartmentation and exchange rates in primary hepatocyte culture.
- A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army.
- The role of cytoplasmic proteins in hepatic bile acid transport.
- Tocopherol-binding proteins of hepatic cytosol.
- Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration.
- Role of glutathione status in protection against ethanol-induced gastric lesions.
- Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol.
- Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes.
- Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human...
- Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids.
- Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms.
- Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids.
- 3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance.
- Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isola...
- Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenase. II. Studies in the prograde and retrograde single-pass...
- Drug-induced hepatotoxicity.
- Subunit heterogeneity of cationic human hepatic glutathione S-transferases.
- Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver.
- Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution.
- Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids.
- Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes.
- Binding of bile acids by glutathione S-transferases from rat liver.
- Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein.
- Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver.
- The regulation of hepatic glutathione.
- Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial.
- Organic anion-binding by human hepatic GSH S-transferases.
- Kinetics of glutathione efflux from isolated rat hepatocytes.
- Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process.
- Modulating effect of thiol-disulfide status on [14C]aminopyrine accumulation in the isolated parietal cell.
- Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol.
- Gamma-glutamylcysteine: a substrate for glutathione S-transferases.
- Quantitative analysis of unconjugated and conjugated bile acids in duodenal fluid by densitometry after paper electrophoresis.
- Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA).
- Role of hepatic anion-binding protein in bromsulphthalein conjugation.
- Postprandial serum bile acid for the detection of hepatobiliary disease.
- Malabsorption secondary to mesenteric ischemia.
- Coproporphyrin I and 3 excretion in bile and urine.
- Isolation of erythrocytes with normal protoporphyrin levels in erythropoietic protoporphyria.
- Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins.
- Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin.
- Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol.
- Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin.
- Role of glutathione in gastric mucosal cytoprotection.
- Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol.
- Binding of glutathione by rat liver cytosol.
- Quantitation and characterization of a newly described organic anion binder by radioimmunoassay.
- Inhibition of glutathione efflux from isolated rat hepatocytes by methionine.
- Newly identified organic anion-binding proteins in rat liver cytosol.
- Newly identified bile acid binders in rat liver cytosol. Purification and comparison with glutathione S-transferases.
- Factors influencing the efflux of hepatic glutathione into bile in rats.
- Extrahepatic obstruction in chronic alcoholic pancreatitis.
- The hepatocellular uptake and biliary excretion of endotoxin in the rat.
- Propylthiouracil treatment for alcoholic hepatitis: should it and does it work?
- Identification of hepatic Z-protein in a marine elasmobranch, Platyrhinoides triseriata.
- Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice.
- Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis.
- Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis.
- Inhibition of rat hepatic thyroxine 5''-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione.
- Glutathione S-transferases in elasmobranch liver. Molecular heterogeneity, catalytic and binding properties, and purification.
- The importance and regulation of hepatic glutathione.
- Halothane-induced hepatic disease.
- Effect of salicylates and phenobarbital on hepatic glutathione in the rat.
- Propylthiouracil. A substrate for the glutathione S-transferases that competes with glutathione.
- Bile acid tolerance tests: rationale.
- Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat.
- Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine.
- Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro.
- Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat.
- Physiological significance of glutathione S-transferases.
- Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells.
- Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats.
- Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activatio...
- Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters.
- Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus...
Schools
New York University
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Elected Member
Education
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Albert Einstein College of Medicine at Jacobi Medical Center -
NYU School of Medicine
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