Physician

Cardiology

Nikolaos Frangogiannis, MD practices Cardiology. He graduated from Baylor College of Medicine. He over the years received 1 awards: "Fellow (FACC)". Nikolaos Frangogiannis is also a published physician. He has 101 paper published. The most recent paper is: Cytokines and the microcirculation in ischemia and reperfusion.

Publications

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• The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardia...
• Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function.
• Targeting the transforming growth factor (TGF)-β cascade in the remodeling heart: Benefits and perils.
• CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans.
• Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities.
• MicroRNAs and Endothelial Function: Many Challenges and Early Hopes for Clinical Applications.
• The inflammatory response in myocardial injury, repair, and remodelling.
• The role of thrombospondin (TSP)-1 in obesity and diabetes.
• Fibroblasts in myocardial infarction: A role in inflammation and repair.
• Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis.
• Targeting inflammatory pathways in myocardial infarction.
• IL-1 Induces Proinflammatory Leukocyte Infiltration and Regulates Fibroblast Phenotype in the Infarcted Myocardium.
• Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction.
• Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation.
• Targeting the chemokines in cardiac repair.
• The pathogenesis of cardiac fibrosis.
• Fibroblasts in post-infarction inflammation and cardiac repair.
• Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts.
• The role of IL-1 in the pathogenesis of heart disease.
• Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes.
• Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload.
• Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity.
• The immune system and cardiac repair.
• Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
• Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction.
• CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response.
• Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function.
• The prognostic value of monocyte chemoattractant protein-1/CCL2 in acute coronary syndromes.
• Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.
• MCP-1/CCL2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy.
• Chemokines in ischemia and reperfusion.
• Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy.
• The role of the thrombospondins in healing myocardial infarcts.
• Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling.
• The role of platelet-derived growth factor signaling in healing myocardial infarcts.
• Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice.
• The role of TGF-beta signaling in myocardial infarction and cardiac remodeling.
• The mechanistic basis of infarct healing.
• Targeting the inflammatory response in healing myocardial infarcts.
• Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction.
• Extracellular matrix remodeling in canine and mouse myocardial infarcts.
• Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability.
• Chemokines in myocardial ischemia.
• Identification of mast cells in the cellular response to myocardial infarction.
• Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts.
• CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts.
• Chemokines in the ischemic myocardium: from inflammation to fibrosis.
• Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts.
• A murine model of ischemic cardiomyopathy induced by repetitive ischemia and reperfusion.
• Targeting the chemokines in myocardial inflammation.
• The role of the chemokines in myocardial ischemia and reperfusion.
• Vascular mural cells in healing canine myocardial infarcts.
• Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction.
• Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting.
• Inflammatory mechanisms in myocardial infarction.
• Myocardial hibernation. Clinical and pathological perspectives.
• MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype.
• The pathological basis of myocardial hibernation.
• Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species.
• Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-2...
• Microvascular structural correlates of myocardial contrast echocardiography in patients with coronary artery disease and left ventricular dysfunction: implications for...
• Mast cells and macrophages in normal C57/BL/6 mice.
• Active interstitial remodeling: an important process in the hibernating human myocardium.
• Evidence for an active inflammatory process in the hibernating human myocardium.
• Morphological characteristics of the microvasculature in healing myocardial infarcts.
• The inflammatory response in myocardial infarction.
• Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals.
• Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia.
• Induction and suppression of interferon-inducible protein 10 in reperfused myocardial infarcts may regulate angiogenesis.
• Is inflammation good for the ischemic heart--perspectives beyond the ordinary.
• Induction of the synthesis of the C-X-C chemokine interferon-gamma-inducible protein-10 in experimental canine endotoxemia.
• Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb).
• IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury.
• Tirofiban for cocaine-induced coronary artery thrombosis: a novel therapeutic approach.
• Histochemical and morphological characteristics of canine cardiac mast cells.
• Cytokines and the microcirculation in ischemia and reperfusion.
• Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions.
• Endocarditis and Ureaplasma urealyticum osteomyelitis in a hypogammaglobulinemic patient. A case report and review of the literature.
• Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion.
• Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion.
• Phagocytes in ischemia injury.
• Cyclophosphamide in the treatment of toxic epidermal necrolysis.
• The role of the neutrophil in myocardial ischemia and reperfusion.
• Pemphigus of the larynx and esophagus.
• Regulation of the inflammatory response in cardiac repair.
• The stromal cell-derived factor-1/CXCR4 axis in cardiac injury and repair.
• Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism.
• TGF-β signaling in fibrosis.
• Stromal cell-derived factor-1-mediated angiogenesis for peripheral arterial disease: ready for prime time?
• The cellular specificity of leptin-mediated actions in the infarcted heart.
• Transforming growth factor (TGF)-β signaling in cardiac remodeling.
• Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.
• CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells.
• The role of inflammatory and fibrogenic pathways in heart failure associated with aging.
• Syndecan-1: a critical mediator in cardiac fibrosis.
• Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock.
• Chemokines in myocardial infarction: translating basic research into clinical medicine.
• Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction.
• The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction.
• Chemokines and cardiac fibrosis.

Schools

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• University of Athens College of Medicine School of Health Science National amp Kapodistrian

• Baylor College Of Med

Doctors Specialties

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• Cardiology

Accepted Insurances

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Awards

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• Fellow (FACC)

Education

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• Baylor College of Medicine
• University of Athens

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