Professor of Pediatrics, Boston Children's Hospital
Hematology
Dr. Orah S. Platt, MD
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Dr. Orah S. Platt practices Hematology. He went to medical school at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Orah Platt is also a published doctor. He has 71 paper published. The most recent paper is: Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
Publications
- Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
- Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
- Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss.
- SLC26A4 c.919-2A>G varies among Chinese ethnic groups as a cause of hearing loss.
- Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice.
- Hydroxyurea for the treatment of sickle cell anemia.
- Quantitative trait loci for peripheral blood cell counts: a study in baboons.
- Quantitative trait loci for baseline erythroid traits.
- Prevention and management of stroke in sickle cell anemia.
- Preventing stroke in sickle cell anemia.
- Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.
- Genetic influences on peripheral blood cell counts: a study in baboons.
- Acquisition of mutans streptococci and caries prevalence in pediatric sickle cell anemia patients receiving long-term antibiotic therapy.
- Development of a focused oligonucleotide-array comparative genomic hybridization chip for clinical diagnosis of genomic imbalance.
- Use of a multiplex PCR/sequencing strategy to detect both connexin 30 (GJB6) 342 kb deletion and connexin 26 (GJB2) mutations in cases of childhood deafness.
- Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transport.
- Effectiveness of sequencing connexin 26 (GJB2) in cases of familial or sporadic childhood deafness referred for molecular diagnostic testing.
- Haemolytic disorders of infancy.
- A high-performance liquid chromatographic assay for the determination of itraconazole concentration using solid-phase extraction and small sample volume.
- Reticulocyte hemoglobin content to diagnose iron deficiency in children.
- Red blood cell size and glycolytic enzyme activity: relationship to number of intramedullary cell divisions.
- Effect of context on the rating of students by faculty and housestaff in a clinical clerkship.
- Toad urinary bladder epithelial cells contain an analogue of cytoskeletal protein 4.1.
- Influence of hydroxyurea on fetal hemoglobin production in vitro.
- Loss of adhesion of erythrocyte precursors to fibronectin during erythroid differentiation.
- Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes.
- Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration.
- HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent.
- Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity.
- A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole.
- Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy.
- Predicting medical student success in a clinical clerkship by rating students' nonverbal behavior.
- Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
- Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity.
- The febrile child with sickle cell disease: a pediatrician's quandary.
- Bone marrow transplantation in sickle cell anemia--the dilemma of choice.
- Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
- Easing the suffering caused by sickle cell disease.
- Mortality in sickle cell disease. Life expectancy and risk factors for early death.
- Membrane protein interactions in sickle red blood cells: evidence of abnormal protein 3 function.
- Sickle cell paths converge on hydroxyurea.
- Sickle reticulocytes adhere to VCAM-1.
- Glycosylation of variant hemoglobins in normal and diabetic subjects.
- Isobutyl nitrite toxicity by ingestion.
- Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity.
- Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration.
- Influence of sickle hemoglobinopathies on growth and development.
- Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.
- Hydroxyurea increases fetal hemoglobin production in sickle cell anemia.
- Is there treatment for sickle cell anemia?
- Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection.
- Membrane protein lesions in erythrocytes with Heinz bodies.
- Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles.
- Pathology of membrane proteins in sickle erythrocytes.
- Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes.
- Chemotherapy to increase fetal hemoglobin in patients with sickle cell anemia.
- Pain in sickle cell disease. Rates and risk factors.
- Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
- Energy reserve and cation composition of irreversibly sickled cells in vivo.
- Newborn bleeding disorders: a practical approach.
- Lung function in children with sickle cell anemia.
- Sickle cell anemia as an inflammatory disease.
- The acute chest syndrome of sickle cell disease.
- Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related.
- Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group.
- Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease.
- A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin.
- Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.
- Association between microdeletion and microduplication at 16p11.2 and autism.
- Age- and gender-dependent obesity in individuals with 16p11.2 deletion.
Schools
Harvard Medical School
Massachusetts General Hospital
Children39s Hospital
Doctors Specialties
- Pediatrics
- Hematology
Accepted Insurances
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- First Health (Coventry Health Care) PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
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Boston Children's Hospital -
Massachusetts General Hospital -
Harvard Medical School
Hospital
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Boston Children's Hospital
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