Director, Division of Endocrinology and Diabetes Department of Pediatrics Washington University School of Medicine

Pediatric Endocrinology

Paul Hruz is an expert in the field of Pediatric Endocrinology. He researched medicine at Medical College of Wisconsin. Medical College of Wisconsin is ranked 54/62 in Research/PrimaryCare. He received 6 awards: "Julio V Santiago Endowed Scholar", "Alpha Omega Alpha", "Armond J Quick Award for Excellence in Biochemistry", "Most Outstanding Resident", "Phi Beta Kappa" and "Fellow (FAAP)". Doctor Paul W. Hruz, MD is also published. He has 44 publications published. The lastest publication: "3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.'

Publications

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• Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.
• The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.
• In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.
• HIV and Endocrine Disorders.
• Isoform-Selective Inhibition of Facilitative Glucose Transporters: Elucidation of the Molecular Mechanism of HIV Protease Inhibitor Binding.
• Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy.
• GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle.
• Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes.
• GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.
• HIV Protease Inhibitors Act as Competitive Inhibitors of the Cytoplasmic Glucose Binding Site of GLUTs with Differing Affinities for GLUT1 and GLUT4.
• Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.
• Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.
• Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice.
• Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
• Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice.
• The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications.
• HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models.
• HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy.
• Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model.
• Rosiglitazone inhibits mouse liver regeneration.
• Molecular Mechanisms for Altered Glucose Homeostasis in HIV Infection.
• Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal.
• A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.
• Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.
• Delayed hepatocellular mitotic progression and impaired liver regeneration in early Growth response-1-deficient mice.
• HIV protease inhibitors acutely impair glucose-stimulated insulin release.
• Indinavir induces acute and reversible peripheral insulin resistance in rats.
• 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL): cloning and characterization of a mouse liver HL cDNA and subchromosomal mapping of the human and mouse HL genes.
• Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines.
• 3-Hydroxy-3-methylglutaryldithio-CoA: utility of an alternative substrate in elucidation of a role for HMG-CoA lyase's cation activator.
• 3-Hydroxy-3-methylglutaryl coenzyme A lyase: affinity labeling of the Pseudomonas mevalonii enzyme and assignment of cysteine-237 to the active site.
• Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.
• 3-Hydroxy-3-methylglutaryl-CoA lyase: expression and isolation of the recombinant human enzyme and investigation of a mechanism for regulation of enzyme activity.
• 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.
• Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism.
• Structural analysis of the GLUT1 facilitative glucose transporter (review).
• The mechanism of insulin resistance caused by HIV protease inhibitor therapy.
• Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter.
• Investigating the cellular targets of HIV protease inhibitors: implications for metabolic Disorders and improvements in drug therapy.
• Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporter.
• Contribution of metabolic and anthropometric abnormalities to cardiovascular Disease risk factors.
• Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations.
• Molecular mechanisms for insulin resistance in treated HIV-infection.

Schools

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• Medical College of Wisconsin

• University Of Wa School Of Med

• Washington University School Of Medicine

Conditions Treated

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• Adrenal Gland Diseases
• Adrenogenital Disorders
• Diabetes Type 1
• Diabetes Type 2
• View All

Doctors Specialties

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• Pediatric Endocrinology

Accepted Insurances

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Awards

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• Julio V Santiago Endowed Scholar
• Alpha Omega Alpha
• Armond J Quick Award for Excellence in Biochemistry
• Most Outstanding Resident
• Phi Beta Kappa
• Fellow (FAAP)

Education

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• Washington University
• University of Washington
• Medical College of Wisconsin

Hospital

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• St. Louis Children's Hospital
• Barnes-Jewish Hospital

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