Shattuck Professor of Pathological Anatomy, Harvard Medical School

Infectious Disease

Peter M. Howley is an expert in the field of Infectious Disease. He studied medicine at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Peter Howley is also published. He has 101 publications published. The lastest publication: "The assembly of the measles virus nucleoprotein into nucleocapsid-like particles is modulated by the phosphoprotein.'

Publications

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• Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2.
• Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens.
• SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter.
• Genus Beta HPV E6 Proteins Vary in their Effects on the Transactivation of p53 Target Genes.
• Proteomic approaches to the study of papillomavirus-host interactions.
• Comprehensive analysis of host cellular interactions with human papillomavirus e6 proteins identifies new e6 binding partners and reflects viral diversity.
• Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes.
• Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.
• The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3.
• NCoR1 mediates papillomavirus E8;E2C transcriptional repression.
• Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.
• Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.
• Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9.
• The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.
• Brd4 regulation of papillomavirus protein E2 stability.
• Regulation of aurora B expression by the bromodomain protein Brd4.
• Small DNA tumor viruses: large contributors to biomedical sciences.
• CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
• Bovine papillomavirus E7 oncoprotein inhibits anoikis.
• Brd4-independent transcriptional repression function of the papillomavirus e2 proteins.
• E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein.
• Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.
• Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.
• E6AP and calmodulin reciprocally regulate estrogen receptor stability.
• Warts, cancer and ubiquitylation: lessons from the papillomaviruses.
• Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.
• Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
• Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.
• Identification of TRAIL as an interferon regulatory factor 3 transcriptional target.
• Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection.
• Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein.
• Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes.
• Ubiquitin recognition by the DNA repair protein hHR23a.
• DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.
• The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome.
• Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.
• Interferon regulatory factor-3 is an in vivo target of DNA-PK.
• Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
• Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B.
• On human papillomaviruses.
• Presence of human papilloma viral antigens in juvenile multiple laryngeal papilloma.
• The effect of a community action intervention on adolescent smoking rates in rural australian towns: the CART project. Cancer Action in Rural Towns.
• DNA sequence of human papovavirus BK.
• Kinetics of inhibition of papovavirus DNA synthesis by superinfection with adenovirus 2 and non-defective adenovirus 2-simian virus 40 hybrid viruses.
• Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
• Oncogenicity of a nude mouse cell line transformed by a human papovavirus.
• Analysis of JC virus DNA purified directly from human progressive multifocal leukoencephalopathy brains.
• A vaccinia virus transfer vector using a GUS reporter gene inserted into the I4L locus.
• U.S.-Japan meeting on "transacting-factors in viral carcinogenesis".
• A functional measles virus replication and transcription machinery encoded by the vaccinia virus genome.
• The human papillomaviruses.
• Genome Structures of reiteration mutants of simian virus 40.
• Characterization of supercoiled oligomeric SV40 DNA molecules in productively infected cells.
• The detection and quantitation of SV40 nucleic acid sequences using single-stranded SV40 DNA probes.
• Tumorigenic latency and separable stages during fibrosarcoma development in transgenic mice carrying papillomavirus genomes.
• In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA.
• Lack of SV40 DNA in tumors from scientists working with SV40 virus.
• Papillomavirus transforming functions.
• A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes.
• Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.
• A 38 bp repeat sequence within the pea seed storage protein promoter of legA is a binding site for a nuclear DNA-binding protein.
• Characterization of the genome of the murine papovavirus K.
• Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.
• Growth potential of sheep and sea mammal cells transformed by SV40 early region DNA.
• Physical map of the BK virus genome.
• Characterization of human papovavirus BK DNA.
• Identification of the primate papovavirus HD as the stump-tailed macaque virus.
• Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae.
• Genome localization of simian virus 40 RNA species.
• Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1.
• Human papillomavirus-11 DNA in a patient with chronic laryngotracheobronchial papillomatosis and metastatic squamous-cell carcinoma of the lung.
• The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex.
• The molecular biology of papillomavirus transformation. Warner-Lambert Parke-Davis Award Lecture.
• Human papillomaviruses: present knowledge, future approaches.
• Posttranscriptional selection of simian virus 40-specific RNA.
• Evaluation of normal and neoplastic human tissue for BK virus.
• Characterization of K virus and its comparison with polyoma virus.
• Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequences.
• Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.
• The role of papillomaviruses in human cancer.
• Cloned human polyomavirus JC DNA can transform human amnion cells.
• Polynucleotide sequences common to the genomes of simian virus 40 and the human papovaviruses JC and BK.
• Novel method for identifying sequence-specific DNA-binding proteins.
• Eukaryotic cloning vectors derived from bovine papillomavirus DNA.
• The colinear alignment of the genomes of papovaviruses JC, BK, and SV40.
• Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
• Conserved polynucleotide sequences among the genomes of papillomaviruses.
• Type 1 human T-cell leukemia virus small envelope protein expressed in mouse cells by using a bovine papilloma virus-derived shuttle vector.
• The assembly of the measles virus nucleoprotein into nucleocapsid-like particles is modulated by the phosphoprotein.
• Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector.
• c-myc and pRB: role in TGF-beta 1 inhibition of keratinocyte proliferation.
• Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues.
• In vivo ubiquitination and proteasome-mediated degradation of p53(1).
• Comparison of Southern blot hybridization and polymerase chain reaction methods for the detection of human papillomavirus DNA.
• Effect of a community action program on adult quit smoking rates in rural australian towns: the CART project.
• The primary structure and genetic organization of the bovine papillomavirus type 1 genome.
• Analysis of dichotomous outcome data for community intervention studies.
• Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice.
• Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells.
• The human papillomaviruses. An overview.

Schools

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• Harvard Medical School

Doctors Specialties

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• Anatomic Pathology
• Infectious Disease

Accepted Insurances

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Awards

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• Elected Member
• Whos Who in Medicine and Healthcare

Education

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• Harvard Medical School

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