Professor, Medicine, University of Florida College of Medicine
Endocrinology
Dr. Peter W. Stacpoole, MD
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Peter Stacpoole is an expert in the field of Endocrinology. He went to medical school at Vanderbilt University School of Medicine. He has 1 awards "Elected Member". Dr. Peter W. Stacpoole is a published physician. He published 98 publications, including: 'Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroace...' Peter W. Stacpoole accepts all Medicare patients.
Publications
- GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
- Pyridoxine supplementation does not alter in vivo kinetics of one-carbon Metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insuf...
- Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
- HaploType variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
- Sleep Disorders Associated with Primary Mitochondrial Diseases.
- Dichloroacetate and cancer: New home for an orphan drug?
- Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haploType-dependent manner.
- Phase 1 trial of dichloroacetate (DCA) in adults With recurrent malignant brain tumors.
- Pharmacokinetics of Oral Dichloroacetate in Dogs.
- Long-term safety of dichloroacetate in congenital lactic acidosis.
- Design and implementation of the first randomized controlled trial of coenzyme Q(10) in children With primary mitochondrial diseases.
- Development of optimized AAV3 seroType vectors: mechanism of high-efficiency transduction of human liver cancer cells.
- Prenatal and Postnatal Expression of Glutathione Transferase Zeta 1 in Human Liver and the Roles of HaploType and Subject Age in Determining Activity with Dichloroacet...
- The spectrum of pyruvate dehydrogenase complex Deficiency: clinical, biochemical and genetic features in 371 patients.
- Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.
- Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate.
- Why are there no proven therapies for genetic mitochondrial diseases?
- Moderate Vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fr...
- The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?
- Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
- An animal model of PDH Deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.
- AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.
- Imaging of Lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS.
- Peripheral neuropathy in rats exposed to dichloroacetate.
- Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate Without affecting red blood cell or plasma glutathione concentrations in healthy ...
- Production of 1-carbon units from glycine is extensive in healthy men and women.
- Moderate dietary Vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cle...
- Evaluation of long-term treatment of children With congenital lactic acidosis With dichloroacetate.
- A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus seroType-specific vectors and dichloroacetate.
- Age-dependent kinetics and Metabolism of dichloroacetate: possible relevance to toxicity.
- Pyruvate dehydrogenase complex Deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.
- Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.
- MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on Lipid content of nerve tissue.
- Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.
- Magnetic resonance spectroscopic investigation of mitochondrial fuel Metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex...
- Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
- Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary Vitamin B-6 restriction in young men and women.
- Peripheral neuropathy in genetic mitochondrial diseases.
- Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine Metabolism following dichloroacetate exposure and withdrawal.
- Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restri...
- The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentra...
- Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.
- Dietary Vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
- Effects of exercise on emerging and traditional cardiovascular risk factors.
- Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma.
- Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
- Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.
- A prospective comparison of malaria With other severe diseases in African children: prognosis and optimization of management.
- Simultaneous determination of trace levels of nine haloacetic acids in biological samples as their pentafluorobenzyl derivatives by gas chromatography/tandem mass spec...
- Efficacy of dichloroacetate as a lactate-lowering drug.
- Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.
- Exercise training, Without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults.
- Gene therapy for pyruvate dehydrogenase E1alpha Deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors.
- QUICKI is not a useful and accurate index of insulin sensitivity following exercise training.
- Renal manifestations of congenital lactic acidosis.
- Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease.
- Dichloroacetate in the treatment of lactic acidosis.
- Developmental pattern of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the rat.
- Development of a noncompetitive, solid phase, bridged biotin-avidin enzyme immunoassay for measurement of human leukocyte microsomal HMG-CoA reductase protein concentr...
- In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Studies in normal subjects.
- Dichloroacetate derivatives. Metabolic effects and pharmacodynamics in normal rats.
- Inhibition of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by ascorbic acid. An effect mediated by the free radical monodehydroascorbate.
- Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate.
- Ascorbic acid regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in guinea pig liver.
- Treatment of streptozotocin Diabetes with di-isopropylammonium dichloroacetate (DIPA).
- A familial glucagonoma syndrome: genetic, clinical and biochemical features.
- Combination H1 and H2 receptor antagonist therapy in Diabetic autonomic neuropathy.
- The glucagonoma syndrome: clinical features, diagnosis, and treatment.
- Isolated ACTH Deficiency: a heterogeneous disorder. Critical review and report of four new cases.
- Somatostatinoma syndrome: does a clinical entity exist?
- Primary empty sella, hyperprolactinemia, and isolated ACTH Deficiency after postpartum hemorrhage.
- Regulation of human leukocyte microsomal hydroxymethylglutaryl-CoA reductase activity by a phosphorylation and dephosphorylation mechanism.
- Measurement of human leukocyte microsomal HMG-CoA reductase activity.
- Regulation of rat liver hydroxymethylglutaryl coenzyme A reductase by a new class of noncompetitive inhibitors. Effects of dichloroacetate and related carboxylic acids...
- Hyperlipoproteinemias: pathogenesis, diagnosis, and treatment.
- Dietary carbohydrate decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in rat liver.
- Treatment of lactic acidosis With dichloroacetate.
- Lactic acidosis associated With metastatic osteogenic sarcoma.
- Stimulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by o,p''-DDD.
- Cholesterol reduction by a high-glucose diet in a patient With homozygous familial hypercholesterolemia. A preliminary report.
- Prolonged hypolactatemia and increased total pyruvate dehydrogenase activity by dichloroacetate.
- Morphologic abnormalities of erythrocytes from patients With homozygous familial hypercholesterolemia.
- Brief treatment With dichloroacetate does not modify suspected subacute necrotizing encephalomyelitis.
- Elevated cholesterol and bile acid synthesis in an adult patient With homozygous familial hypercholesterolemia. Reduction by a high glucose diet.
- Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans.
- Kinetic evidence for both a fast and a slow secretory pathway for apolipoprotein A-I in humans.
- Plasmodium berghei infection: dichloroacetate improves survival in rats With lactic acidosis.
- Pharmacokinetics and pharmacodynamics of dichloroacetate in children With lactic acidosis due to severe malaria.
- Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group.
- Nutrition principles for the management of Diabetes and related complications.
- ApoB Metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm.
- Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme A reductase in HepG2 cells.
- Lactic acidosis and other mitochondrial Disorders.
- The 3H-leucine tracer: its use in kinetic studies of plasma lipoproteins.
- Pharmacokinetics of dichloroacetate in adult patients With lactic acidosis.
- Kinetics and Metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite.
- Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroace...
Schools
Vanderbilt University
Vanderbilt University Med Center
Conditions Treated
- AdRenal Insufficiency
- Calcium Metabolism Disorders
- Diabetes Mellitus, Secondary
- Diabetes Type 1
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Vanderbilt University -
Vanderbilt University School of Medicine
Hospital
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UF Health Shands Hospital
Drug Facts
| NPI NUMBER | 1558474478 | |
| NPPES Provider LastName | STACPOOLE | |
| NPPES Provider FirstName | PETER | |
| NPPES Provider ZIPCode | 326103003 | |
| NPPES Provider State | FL | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 36.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1558474478 |
| Last Name Of The Provider | STACPOOLE |
| First Name Of The Provider | PETER |
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