Professor, Pediatrics, Brown University
Pediatric Endocrinology
Dr. Philip A. Gruppuso, MD
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Philip Gruppuso works in the field of Pediatric Endocrinology. He studied medicine at University of Rochester School of Medicine and Dentistry. Philip Gruppuso is a published physician. He has 100 papers published. The most current publication "A novel presentation of Addison disease: hypoglycemia unawareness in an adolescent with insulin-dependent diabetes mellitus."
Publications
- The Association Between Premedical Curricular and Admission Requirements and Medical School Performance and Residency Placement: A Study of Two Admission Routes.
- Regulation of liver development: implications for liver biology across the lifespan.
- Persistent Effect of mTOR Inhibition on Preneoplastic Foci Progression and Gene Expression in a Rat Model of Hepatocellular Carcinoma.
- Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR).
- Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit.
- Xenotransplantation models to study the effects of toxicants on human fetal tissues.
- Xenotransplantation of human fetal adipose tissue: a model of in vivo adipose tissue expansion and adipogenesis.
- Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).
- Phosphoproteomic analysis of liver homogenates.
- The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
- Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion.
- Mentoring fathers of children newly diagnosed with T1DM.
- Beta-adrenergic receptors (betaAR) regulate cardiomyocyte proliferation during early postnatal life.
- Thyroid storm in a child following radioactive iodine (RAI) therapy: a consequence of RAI versus withdrawal of antithyroid medication.
- Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.
- Hepatic growth hormone signaling in the late gestation fetal rat.
- Patterns of gene expression and DNA methylation in human fetal and adult liver.
- A 5-year experience with an elective scholarly concentrations program.
- Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat.
- Growth regulation via p38 mitogen-activated protein kinase in developing liver.
- Cell cycle control during liver development in the rat: evidence indicating a role for cyclin D1 posttranscriptional regulation.
- Gender self-reassignment in an XY adolescent female born with ambiguous genitalia.
- The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes.
- A novel presentation of Addison disease: hypoglycemia unawareness in an adolescent with insulin-dependent diabetes mellitus.
- Uncoupling of hepatic, epidermal growth factor-mediated mitogen-activated protein kinase activation in the fetal rat.
- Modulation of mitogen-independent hepatocyte proliferation during the perinatal period in the rat.
- Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro.
- A comparative study of the hepatic mitogen-activated protein kinase and Jun-NH2-terminal kinase pathways in the late-gestation fetal rat.
- A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured f...
- Exercise fails to improve postprandial glycemic excursion in women with gestational diabetes.
- Regulation of preadipocyte factor-1 gene expression during 3T3-L1 cell differentiation.
- Spatiotemporal expression of two cell-cell adhesion molecule 105 isoforms during liver development.
- Hyperinsulinemia in macrosomic infants of nondiabetic mothers.
- Prenatal diagnosis of familial neonatal hyperinsulinemia.
- Evidence for a direct hepatotrophic role for insulin in the fetal rat: implications for the impaired hepatic growth seen in fetal growth retardation.
- Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture.
- Hyperinsulinemia and macrosomia in the fetus of the diabetic mother.
- In vitro and in vivo regulation of hepatic mitogen-activated protein kinases in fetal rats.
- Developmental changes in the activity and cellular localization of hepatic casein kinase II in the rat.
- Lack of production and growth-modulating effects of 1a,25-dihydroxyvitamin D3 in cultured fetal rat hepatocytes.
- Chronic maternal hyperinsulinemia and hypoglycemia. A model for experimental intrauterine growth retardation.
- Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
- Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.
- Chronic hyperglucagonemia in rats: effects on insulin, substrates, and hepatic enzymes of intermediary metabolism.
- DDT inhibition of active chlorophenol red transport in goldfish (Carassius auratus) renal tubules.
- Near-total pancreatectomy for hyperinsulinism. Spontaneous remission of resultant diabetes.
- Preserved fetal plasma amino acid concentrations in the presence of maternal hypoaminoacidemia.
- Metabolism and placental transfer of 125I-proinsulin and 125I-tyrosylated C-peptide in the pregnant rhesus monkey.
- A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.
- Postpartum testing for antecedent gestational diabetes.
- Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins.
- Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene.
- Phosphorylase phosphatase catalytic subunit. Evidence that the Mr = 33,000 enzyme fragment is derived from a native protein of Mr = 70,000.
- Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000.
- Induction in utero of hepatic glucose-6-phosphatase by fetal hypoinsulinemia.
- Binding of proinsulin and proinsulin conversion intermediates to human placental insulin-like growth factor I receptors.
- Compartmentalized protein phosphorylation/dephosphorylation in glycogen particles from rabbit skeletal muscle.
- Latent forms of type-1 protein phosphatase in rabbit skeletal muscle.
- Hypoglycemia in children.
- Effects of fetal hypoinsulinemia on fetal hepatic insulin binding in the rat.
- Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat.
- Induction of hepatic glycogenesis in the fetal rat.
- Differential response of nontumorigenic and tumorigenic human papillomavirus type 16-positive epithelial cells to transforming growth factor beta 1.
- Hepatic protein kinase-C and protein phosphatase type-2A in the fetal rat.
- Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats.
- Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat.
- Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy.
- Ontogeny of hepatic type I insulin-like growth factor receptors in the rat.
- Hepatic protein tyrosine phosphatases in the rat.
- Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes.
- Hepatic insulin and EGF receptor phosphorylation and dephosphorylation in fetal rats.
- Fetal growth factors as determinants of intrauterine hepatic growth.
- Effects of TGF-beta s in the liver: cell proliferation and fibrogenesis.
- Protein tyrosine phosphatase activation during nerve growth factor-induced neuronal differentiation of PC12 cells.
- Heterogeneity of hepatic protein tyrosine phosphatases.
- Insulin receptor tyrosine kinase domain auto-dephosphorylation.
- Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats.
- Resveratrol inhibits protein translation in hepatic cells.
- Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1).
- The physiology and pathophysiology of rapamycin resistance: implications for cancer.
- Hepatocyte nuclear factor 4α gene mutation associated with familial neonatal hyperinsulinism and maturity-onset diabetes of the young.
- The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells.
- Commentary: the unsustainable cost of undergraduate medical education: an overlooked element of U.S. health care reform.
- Encouraging scholarship: medical school programs to promote student inquiry beyond the traditional medical curriculum.
- Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).
- Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines.
- Disorders of the growth plate.
- Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.
- The effect of rapamycin on bone growth in rabbits.
- Hepatic translation control in the late-gestation fetal rat.
- The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats.
- mTOR signaling contributes to chondrocyte differentiation.
- Re: Houk CP, et al. Intersex classification scheme: a response to the call for a change. J Pediatr Endocrinol Metab 2005; 18: 735-738.
- The role of insulin in chondrogenesis.
- Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation.
- Changing the nomenclature/taxonomy for intersex: a scientific and clinical rationale.
- Coordinated regulation of c-Myc and Max in rat liver development.
- The role of nuclear factor kappaB in late-gestation liver development in the rat.
- D-type cyclins and G1 progression during liver development in the rat.
Schools
University Of Rochester
Rhode Island Hospital Lifespan
Doctors Specialties
- Pediatric Endocrinology
Accepted Insurances
Education
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Brown University Affiliated Hospitals -
Brown University -
University of Rochester School of Medicine and Dentistry
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