Physician
Gastroenterology
Dr. Philip S. Guzelian Jr., MD
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Doctor Philip S. Guzelian Jr., MD works in the field of Gastroenterology. He graduated from Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7 in research and 57 in primary care medicine Philip Guzelian is a published doctor and has 90 publications published. The lastest was: 'Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23.'
Publications
- Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.
- Authority-based explanation.
- Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).
- Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism.
- Stimulation of fibrinogen synthesis in cultured rat hepatocytes by fibrinogen fragment E.
- Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.
- Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes.
- Colchicine does not provide a sustained blockage of collagen and plasma protein secretion by rat hepatocytes.
- Identification of an inducible form of cytochrome P-450 in human liver.
- Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning.
- Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
- Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.
- Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene.
- Hepatocyte culture in study of P450 regulation.
- Studies of the formation and relase of glycerolipids by primary monolayer cultures of adult rat hepatocytes.
- Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix.
- Hepatocellular phenotype in vitro is influenced by biophysical features of the collagenous substratum.
- Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.
- Mechanisms of recovery from mechanical injury of cultured rat hepatocytes.
- Phenotypic stability of adult rat hepatocytes in primary monolayer culture.
- Drug metabolism in adult rat hepatocytes in primary monolayer culture.
- Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.
- Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture.
- Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.
- Expression of cytochrome P450 3A in amphibian, rat, and human kidney.
- Effects of hormones on changes in cytochrome P-450, prolyl hydroxylase, and glycerol phosphate acyltransferase in primary monolayer cultures of parenchymal cells from ...
- Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.
- Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats.
- Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.
- Ascorbic acid deficiency and cytochrome P-450 in adult rat hepatocytes in primary monolayer culture.
- Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation.
- Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.
- Glucocorticoids suppress formation of collagen by the hepatocyte. Studies in primary monolayer cultures of parenchymal cells prepared from adult rat liver.
- Mechanisms of alcohol impairment of recovery from mechanically denuded areas made within cultured rat hepatocytes.
- Rapid loss of delta-aminolevulinic acid dehydratase activity in primary cultures of adult rat hepatocytes: a new model of zinc deficiency.
- Retention of clostridial collagenase by primary cultures of parenchymal cells prepared from adult rat liver.
- Effect of cobalt on synthesis of heme and cytochrome P-450 in the liver. Studies of adult rat hepatocytes in primary monolayer culture and in vivo.
- Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.
- Induction of cytochromes P-450b/e by phenobarbital in primary culture of adult rat hepatocytes: test of differentiated liver gene expression.
- Relevance of rat liver tumors to human hepatic and endometrial cancer.
- Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo.
- Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.
- Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression.
- Inhibition by cycloheximide of degradation of cytochrome P-450 in primary cultures of adult rat liver parenchymal cells and in vivo.
- Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes.
- Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.
- Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes.
- Collagen formation by the hepatocyte in primary monolayer culture and in vivo.
- Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes.
- Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.
- Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers.
- Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
- Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
- Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.
- Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.
- Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel.
- Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes.
- Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel.
- Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix.
- Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultur...
- 4.5 Evidence-based individual toxicological analysis.
- Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes.
- Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitoge...
- Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes.
- Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes.
- Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel.
- Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes.
- Measurement of the metabolism of cytochrome P-450 in cultured hepatocytes by a quantitative and specific immunochemical method.
- Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mech...
- Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion.
- Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
- Cyp3A regulation: from pharmacology to nuclear receptors.
- Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel.
- Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by tr...
- Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23.
- Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-st...
- Humanized xenobiotic response in mice expressing nuclear receptor SXR.
- A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids.
- Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.
- Induction of cytochrome P-450 by pregnenolone-16 alpha-carbonitrile in primary monolayer cultures of adult rat hepatocytes and in a cell-free translation system.
- Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a ...
- 1.3 Consensus, opinion, and evidence-based science - three methods of reaching conclusions in toxicology.
- Critical role of extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes.
- Characterization of a pretranscriptional pathway for induction by phenobarbital of cytochrome P450 3A23 in primary cultures of adult rat hepatocytes.
- Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cult...
- Clear path: towards an evidence-based toxicology (EBT).
- Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile.
- Evidence-based toxicology: a comprehensive framework for causation.
- Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agon...
Schools
University of Wisconsin Madison
Metro Genl Hospital
University Wisc Hospital
Yale University
Doctors Specialties
- Internal Medicine
- Gastroenterology
Accepted Insurances
Education
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Yale University School of Medicine -
University of Wisconsin -
Case Western Reserve University - MetroHealth -
University of Wisconsin School of Medicine and Public Health
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