Pediatrics

Dr. R A. Ezekowitz, MD

R A. Ezekowitz, MD is an expert in the field of Pediatrics. Ezekowitz is a published doctor and has 101 publications published. The lastest was: 'The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity.'

Publications

High-dose mannose-binding lectin therapy for Ebola virus infection.
A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus.
Mannose-binding lectin and innate immunity.
Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.
Phagocytosis and comparative innate immunity: learning on the fly.
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.
A systems biology analysis of the Drosophila phagosome.
Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.
Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis.
Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells.
Characterization of an equine mannose-binding lectin and its roles in disease.
Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa.
The mannose-binding lectin: a prototypic pattern recognition molecule.
Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection.
The role of the mannose-binding lectin in innate immunity.
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.
Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.
Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.
Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury.
The mannose-binding lectin: an infection susceptibility gene.
Phagocytosis: elegant complexity.
Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells.
Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype.
Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus.
TLR-independent pattern recognition receptors and anti-inflammatory mechanisms.
Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile.
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-2004. A newborn girl with a large cutaneous lesion, thrombocytopenia,...
Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila.
Role of the mannose-binding lectin in innate immunity.
A case of familial meningococcal disease due to deficiency in mannose-binding lectin (MBL).
Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis.
Local opsonization for apoptosis?
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.
The complement response against an oncolytic virus is species-specific in its activation pathways.
Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria.
Toll-like receptors as sensors of pathogens.
Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.
Recombinant expression of human mannan-binding lectin.
What is the best way to treat inherited disorders?
Pneumocystis carinii enhances soluble mannose receptor production by macrophages.
Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera.
A soluble mannose receptor immunoadhesin enhances phagocytosis of Pneumocystis carinii by human polymorphonuclear leukocytes in vitro.
Update on chronic granulomatous disease: the concept of the near-normal host.
Development of chimeric collectins with enhanced activity against influenza A virus.
Association of familial deficiency of mannose-binding lectin and meningococcal disease.
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.
Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a.
Phylogenetic perspectives in innate immunity.
Phagocytosis and development: back to the future.
The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity.
Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation.
Th1 and Th2 cytokines cooperate to stimulate mannose-receptor-mediated phagocytosis.
Cerebral vasculopathy and neurologic sequelae in infants with cervicofacial hemangioma: report of eight patients.
Distribution of murine mannose receptor expression from early embryogenesis through to adulthood.
Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis.
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy.
The mannose receptor is a pattern recognition receptor involved in host defense.
Genetic heterogeneity of mannose-binding proteins: the Jekyll and Hyde of innate immunity?
Murine macrophage mannose receptor promoter is regulated by the transcription factors PU.1 and SP1.
Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression.
The relationship between facial and airway hemangiomas: does seeing red bode ill?
Successful treatment of infantile hemangiomas with interferon-alpha-2b.
Interaction of human mannose-binding protein with Mycobacterium avium.
Role of gamma interferon in the host immune and inflammatory responses to Pneumocystis carinii infection.
Hepatic vascular anomalies in infancy: a twenty-seven-year experience.
The major surface glycoprotein of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein.
Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells.
The collectins in innate immunity.
Interactions of human mannose-binding protein with lipoteichoic acids.
A serum mannose-binding lectin mediates complement-dependent lysis of influenza virus-infected cells.
The Gly-54-->Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease.
Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor.
Agalactosyl IgG and mannose-binding proteins: biochemical nicety or pathophysiological paradigm?
Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes.
The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize to chromosomes 14 and 19.
Role of macrophage oxidative burst in the action of anthrax lethal toxin.
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil.
Crystallization and preliminary X-ray analysis of a trimeric form of human mannose binding protein.
Assignment of the human macrophage mannose receptor gene (MRC1) to 10p13 by in situ hybridization and PCR-based somatic cell hybrid mapping.
Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription in...
Cellular markers that distinguish the phases of hemangioma during infancy and childhood.
Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin.
The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene Mrc1: identification of a Ricin-like domain at the N-terminus of t...
Treatment of chronic granulomatous disease.
Characterization of Xenopus laevis complement factor I structure--conservation of modular structure except for an unusual insert not present in human factor I.
Screening for inhibitors of HIV gp120-CD4 binding using an enzyme-linked immunoabsorbent assay.
Human mannose-binding protein functions as an opsonin for influenza A viruses.
Collectins: pattern recognition molecules involved in first line host defense.
HIV impairs alveolar macrophage mannose receptor function against Pneumocystis carinii.
Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues.
Truncated forms of mannose-binding protein multimerize and bind to mannose-rich Salmonella montevideo but fail to activate complement in vitro.
Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor.
Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the lev...
Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.
Distinct and overlapping functions of allelic forms of human mannose binding protein.
The role of mannose-binding proteins in host defense.
Interferon alfa-2a therapy for life-threatening hemangiomas of infancy.
Antigens coming to a sticky end.
Monocytes from patients with atopic dermatitis are primed for superoxide production.

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Pediatrics

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