Associate Professor, Pediatrics, Brown University Program in Medicine
Pediatric Hematology & Oncology
Dr. Rachel A. Altura, MD
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Rachel A. Altura practices Pediatric Hematology & Oncology. She attended Washington University School of Medicine in St. Louis. She has 1 awards "Regional Top Doctor". Dr. Rachel A. Altura is a published physician as well. She has 33 publications published. The latest was: The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells.
Publications
- XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer.
- Targeting survivin's co-conspirators: do alternative methods of trapping survivin in the nucleus have potential in triple-negative breast Cancer therapy?
- The CRM1 nuclear export protein in normal development and Disease.
- Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast Cancer.
- Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.
- EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-Cells.
- A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic Anemia.
- Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive Leukemia cells.
- Liver transplant for relapsed undifferentiated embryonal Sarcoma in a young child.
- Poor outcome in a pediatric patient with Acute myeloid leukemia associated with a variant t(8;21) and trisomy 6.
- Postnatal expansion of the pancreatic beta-Cell mass is dependent on survivin.
- Lack of endothelial Cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.
- Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis.
- Survivin: an inhibitor of apoptosis in pediatric Cancer.
- Survivin and Granzyme B-induced apoptosis, a novel antiCancer therapy.
- Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo.
- Essential role for survivin in early brain development.
- Survivin splice variants regulate the balance between proliferation and Cell death.
- Survivin 2alpha: a novel Survivin splice variant expressed in human Malignancies.
- Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome.
- Serum ionized magnesium levels and ionized calcium-to-magnesium ratios in adult patients with sickle cell Anemia.
- Aberrant regulation of survivin by the RB/E2F family of proteins.
- Inflammatory myofibroblastic tumor following hematopoietic stem Cell transplantation: report of two pediatric cases.
- Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.
- Inactivation of E2F3 results in centrosome amplification.
- Hydroxyurea therapy associated with declining serum levels of magnesium in children with sickle cell Anemia.
- Long-term survival of infants with idiopathic myelofibrosis.
- The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid Leukemia cells.
- Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization.
- Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization.
- Sequence requirements for branch formation in a group II self-splicing intron.
- Quantitative Phosphoproteomic Analysis Identifies Activation of the RET and IGF-1R/IR Signaling Pathways in Neuroblastoma.
Schools
Washington Center School of Medicine
Procedures Preformed
- Plasmapheresis
Conditions Treated
- Acute Leukemia
- Anemia
- Deep Vein Thrombosis (DVT)
- Graft vs Host Disease
- View All
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Regional Top Doctor
Education
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University of Tennessee -
Washington University School of Medicine in St. Louis
Hospital
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Rhode Island Hospital
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