Neonatology Children's Hospital Philadelphia
Neonat/Perinatology
Dr. Rebecca A. Simmons, MD
Doctor Rebecca A. Simmons, MD works in the field of Neonat/Perinatology. She attended University of Arizona College of Medicine - Tucson. University of Arizona College of Medicine - Tucson has a rank of 67 in research and a 42 in primary care Rebecca Simmons is a published physician as well. She has 55 publications published. The latest was: Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats.
Publications
- Effect of placental restriction and neonatal exendin-4 treatment on postnatal growth, adult body composition and in vivo glucose metabolism in the sheep.
- Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice.
- Bisphenol A exposure disrupts metabolic health across multiple generations in the mouse.
- I'm Eating for Two: Parental Dietary Effects on Offspring Metabolism.
- Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats.
- Prenatal programming of insulin secretion in intrauterine growth restriction.
- Obesity at Conception Programs the Opioid System in the Offspring Brain.
- Preeclampsia and Prematurity as Precursors to Adolescent Obesity.
- Developmental origins of diabetes: The role of oxidative stress.
- Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4.
- Metabolic programming, epigenetics, and gestational diabetes mellitus.
- Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
- Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrity.
- Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats.
- Neonatal exendin-4 leads to protection from reperfusion injury and reduced rates of oxidative phosphorylation in the adult rat heart.
- Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.
- Setting the "clock": importance of maternal diet.
- Epigenetic mechanisms in the development of type 2 diabetes.
- Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats.
- Oxidative stress disrupts oligodendrocyte maturation.
- Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF.
- Developmental origins of adult disease.
- Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.
- Role of metabolic programming in the pathogenesis of beta-cell failure in postnatal life.
- Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms.
- Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
- Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure.
- Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.
- Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.
- Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats.
- Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.
- Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat.
- Gestational diabetes leads to the development of diabetes in adulthood in the rat.
- Developmental origins of diabetes: the role of epigenetic mechanisms.
- Intrauterine growth retardation alters mitochondrial gene expression and function in fetal and juvenile rat skeletal muscle.
- Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive.
- The effect of insulin and insulin-like growth factor-I on glucose transport in normal and small for gestational age fetal rats.
- Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat.
- Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.
- Glucose regulates glut 1 function and expression in fetal rat lung and muscle in vitro.
- Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats.
- Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.
- Circulating levels of insulin, insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins in the small for gestational age fetal rat.
- The effects of severe maternal diabetes on glucose transport in the fetal rat.
- Intrauterine growth retardation: fetal glucose transport is diminished in lung but spared in brain.
- Circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) and hepatic mRNA are increased in the small for gestational age (SGA) fetal rat.
- Effect of uteroplacental insufficiency upon brain neuropeptide Y and corticotropin-releasing factor gene expression and concentrations.
- Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice.
- Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.
- Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction.
- Modulation of glucose transport in fetal rat lung: a sexual dimorphism.
- Review: Placental programming of postnatal diabetes and impaired insulin action after IUGR.
- Substrate utilization by the fetal sheep lung during the last trimester.
- Late gestation alterations in fetal pulmonary lactate metabolism in vivo.
Schools
University Of Arizona College Of Medicine
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Education
-
University of Arizona -
University of Arizona College of Medicine - Tucson
Hospital
-
Hospital of the University of Pennsylvania
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