Physician
Infectious Disease
Dr. Richard A. Koup, MD
Richard Koup practices Infectious Disease. He has 1 awards "Elected Member". Richard A. Koup, MD is a published physician as well. He has 100 publications published. The latest was: HIV-1 monoclonal antibodies suppress acute SHIV viremia and limit seeding of cell-associated viral reservoirs.
Publications
- Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, ...
- HIV-1 monoclonal antibodies suppress acute SHIV viremia and limit seeding of cell-associated viral reservoirs.
- Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site.
- Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.
- A Monovalent Chimpanzee Adenovirus Ebola Vaccine - Preliminary Report.
- Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial.
- Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, rando...
- DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild Type Glycoproteins are Safe and Immunogenic in a Phase I Clinical Trial.
- Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge.
- Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals.
- Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.
- T follicular helper cells and HIV/SIV-specific antibody responses.
- Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
- Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy chain lineages.
- Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.
- Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
- Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression.
- Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.
- T Cell Susceptibility to HIV Influences Outcome of Opportunistic Infections.
- A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling.
- Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers.
- The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains.
- HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
- Therapeutic Vaccination Expands and Improves the Function of the HIV-specific Memory T Cell Repertoire.
- Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-...
- Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial.
- Influenza virus h5 DNA vaccination is immunogenic by intramuscular and intradermal routes in humans.
- WITHDRAWN:CD8 T cells in PreventingHIV Infection and Disease.
- OMIP-009: Characterization of antigen-specific human T-cells.
- Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation.
- Vaccine design for CD8 T lymphocyte responses.
- Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.
- Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.
- Heavy metal contaminants can eliminate quantum dot fluorescence.
- CD8(+) cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates.
- Monitoring CD27 Expression to Evaluate Mycobacterium Tuberculosis Activity in HIV-1 Infected Individuals In Vivo.
- Standard practice for cell sorting in a BSL-3 facility.
- Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.
- Amine-reactive dyes for dead cell discrimination in fixed samples.
- Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species.
- Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination.
- A steady state of CD4+ T cell memory maturation and activation is established during primary subtype C HIV-1 infection.
- Safety and immunogenicity study of Multiclade HIV-1 adenoviral vector vaccine alone or as boost following a multiclade HIV-1 DNA vaccine in Africa.
- Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization.
- Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
- Lack of in vivo compartmentalization among HIV-1 infected naïve and memory CD4+ T cell subsets.
- Systemic and mucosal T-lymphocyte activation induced by recombinant adenovirus vaccines in rhesus monkeys.
- Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection.
- Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.
- Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.
- Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials.
- Emerging concepts in the immunopathogenesis of AIDS.
- Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection.
- Optimizing peptide matrices for identifying T-cell antigens.
- Biodistribution and toxicological safety of adenovirus type 5 and type 35 vectored vaccines against human immunodeficiency virus-1 (HIV-1), Ebola, or Marburg are simil...
- Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
- A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial.
- Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection.
- SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
- Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses.
- Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
- Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses.
- Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects.
- Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.
- Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.
- A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial.
- PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
- Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry.
- Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients.
- Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.
- Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo.
- HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.
- In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell tr...
- Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.
- Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.
- Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
- Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.
- HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
- Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells.
- Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells.
- Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells.
- Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.
- Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy.
- Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys.
- T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
- Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing...
- Reconsidering early HIV treatment and supervised treatment interruptions.
- Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.
- Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know.
- High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.
- Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development.
- The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration.
- Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells.
- HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters.
- T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis.
- Detection of T-cell degranulation: CD107a and b.
- Viable infectious cell sorting in a BSL-3 facility.
- Biohazard sorting.
- Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Helpful Reviews
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