Professor, Molecular and Integrative Physiology, University of Michigan Medical School
Endocrinology
Dr. Richard M. Mortensen, MD
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Richard Mortensen works in the field of Endocrinology. He attended Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18/49 in Research/PrimaryCare. Richard Mortensen is a published doctor and has 66 publications published. The lastest was: 'Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit.'
Publications
- Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury.
- Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling.
- Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts.
- Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.
- Immune cell modulation of cardiac remodeling.
- Nuclear receptor control of opposing macrophage phenotypes in cardiovascular disease.
- μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception.
- Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia.
- Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.
- RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.
- Selection of transfected mammalian cells.
- In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.
- Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature.
- G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes.
- PPAR-gamma in the Cardiovascular System.
- Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.
- Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality.
- Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.
- Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice.
- RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.
- Genetic determinants of nonmodulating hypertension.
- Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets.
- Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice.
- Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages.
- Overview of gene targeting by homologous recombination.
- Acyl-CoA synthetase in rat liver peroxisomes. Computer-assisted analysis of cell fractionation experiments.
- Production of a heterozygous mutant cell line by homologous recombination (single knockout).
- Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
- Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors.
- Production of homozygous mutant ES cells with a single targeting construct.
- Hysteresis in the relationship between serum ionized calcium and intact parathyroid hormone during recovery from induced hyper- and hypocalcemia in normal humans.
- Comparison of protein phosphorylation patterns produced in adrenal cells by activation of cAMP-dependent protein kinase and Ca-dependent protein kinase.
- Activation of Rap1B by G(i) family members in platelets.
- Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study.
- Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress.
- Inactivation of G-protein genes: double knockout in cell lines.
- Double knockouts. Production of mutant cell lines in cardiovascular research.
- Robust acinar cell transgene expression of CreErT via BAC recombineering.
- Regulation of alpha o expression by the 5'-flanking region of the alpha o gene.
- Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2.
- Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.
- Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
- Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem ...
- Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.
- Dose effect of adrenocorticotropin on aldosterone and cortisol biosynthesis in cultured bovine adrenal glomerulosa cells: in vitro correlate of hyperreninemic hypoaldo...
- Production of a homozygous mutant embryonic stem cell line (double knockout).
- PPARgamma-dependent and PPARgamma-independent effects on the development of adipose cells from embryonic stem cells.
- Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit.
- E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis.
- Effect of progesterone on aldosterone secretion in rats.
- Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations.
- PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
- The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
- Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.
- Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice.
- PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis.
- Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin.
- Impaired activation of murine platelets lacking G alpha(i2).
- Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity.
- beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation.
- Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.
- Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes.
- Human pancreatic acinar cells do not respond to cholecystokinin.
- Direct monitoring pressure overload predicts cardiac hypertrophy in mice.
- PPARs: the vasculature, inflammation and hypertension.
Schools
Weill Cornell Medical College
Doctors Specialties
- Endocrinology
Accepted Insurances
Education
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Brigham and Women's Hospital -
Duke University Hospital -
Weill Cornell Medical College of Cornell University
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