Professor of Medicine, Brigham and Women's Hospital
Gastroenterology
Dr. Richard S. Blumberg, MD
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Dr. Richard S. Blumberg practices Gastroenterology. He graduated from Jefferson Medical College. He has 2 awards "Fellow (AGAF)" and "Elected Member". Dr. Richard S. Blumberg is also published. He has 97 publications published. The lastest publication: "Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice.'
Publications
- Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice.
- IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.
- Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease.
- Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.
- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
- Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
- ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells.
- Commensal microbial regulation of natural killer T cells at the frontiers of the mucosal immune system.
- Protective mucosal immunity mediated by epithelial CD1d and IL-10.
- Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease.
- Cell biology: Stressful genetics in Crohn's disease.
- Involvement of the iNKT Cell Pathway Is Associated With Early-Onset Eosinophilic Esophagitis and Response to Allergen Avoidance Therapy.
- Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.
- Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer.
- Transepithelial transport of fc-targeted nanoparticles by the neonatal fc receptor for oral delivery.
- Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.
- Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.
- CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
- Cross-presentation of IgG-containing immune complexes.
- Immunology. Welcome to the microgenderome.
- Analyzing antigen recognition by natural killer T cells.
- The immunologic functions of the neonatal Fc receptor for IgG.
- Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells.
- The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction.
- Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.
- Microbiota, disease, and back to health: a metastable journey.
- Microbial exposure during early life has persistent effects on natural killer T cell function.
- Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance.
- Unraveling the autoimmune translational research process layer by layer.
- CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells.
- The phospholipid transfer activity of MTP produces apoB-lipoproteins and reduces hepatosteatosis while maintaining low plasma lipids.
- A novel role for IL-27 as mediator of intestinal epithelial barrier protection mediated via differential STAT signaling and induction of antibacterial and anti-inflamm...
- Genetically determined epithelial dysfunction and its consequences for microflora-host interactions.
- Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis.
- "What Color Is my Parachute": Career Opportunities in Academic Gastroenterology and Hepatology.
- Interleukin-35 Mediates Mucosal Immune Responses that Protect Against T-Cell-Dependent Colitis.
- The unfolded protein response and its role in intestinal homeostasis and inflammation.
- Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
- Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease.
- "ER stress(ed out)!": Paneth cells and ischemia-reperfusion injury of the small intestine.
- Crohn's disease: NOD2, autophagy and ER stress converge.
- Essential role for mast cell tryptase in acute experimental colitis.
- Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation.
- Controversy over NOD2, inflammation, and defensins.
- Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
- Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis.
- Gamma interferon produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection.
- The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner.
- Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.
- Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation.
- An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.
- High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.
- Editorial: CEACAM1: fine-tuned for fine-tuning.
- Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
- The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
- Cd1d-dependent regulation of bacterial colonization in the intestine of mice.
- N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
- The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
- Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.
- XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
- Dependence of antibody-mediated presentation of antigen on FcRn.
- Adaptive immunity in inflammatory bowel disease: state of the art.
- Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.
- Fcgamma receptor regulation of Citrobacter rodentium infection.
- IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
- Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway.
- Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity.
- Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.
- Roles of CD1d-restricted NKT cells in the intestine.
- CCFA microbial-host interactions workshop: highlights and key observations.
- MTP regulated by an alternate promoter is essential for NKT cell development.
- CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity.
- Dependence of intestinal granuloma formation on unique myeloid DC-like cells.
- TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.
- SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.
- Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions.
- Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.
- Role of CEACAM1 as a regulator of T cells.
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
- Presentation of the Julius M. Friedenwald Medal to Norton J. Greenberger, MD.
- Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation.
- The role of the epithelial barrier in inflammatory bowel disease.
- An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice.
- Eosinophils alter colonic epithelial barrier function: role for major basic protein.
- Antibodies in the breakdown lane.
- Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.
- Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum.
- Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.
- Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha.
- EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.
- Natural killer T cells in mucosal homeostasis.
- Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules.
- The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells.
- TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response.
- Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion.
- Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway.
Schools
Thomas Jefferson University
New York Hospital Cornell
Brigham Womens HospHarvard
Mass Genl HospHarvard
Doctors Specialties
- Gastroenterology
- Infectious Disease Medicine
Accepted Insurances
Awards
- Fellow (AGAF)
- Elected Member
Education
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Brigham and Women's Hospital -
Massachusetts General Hospital -
New York Presbyterian Hospital - Cornell Campus -
Jefferson Medical College
Hospital
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Brigham and Women's Hospital
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