Physician
Nephrology
Dr. Roger C. Wiggins, MD
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Roger Wiggins works in the field of Nephrology. He has 1 awards "CMS Meaningful Use Stage 1 Certification". Roger Wiggins is a published doctor as well. He has 95 publications published. The latest was: A large outbreak of cryptosporidiosis associated with a public water supply from a deep chalk borehole. Outbreak Investigation Team.
Publications
- Proximal Tubules Have the Capacity to Regulate Uptake of Albumin.
- Glomerular Disease: Looking beyond Pathology.
- Urine podocin:nephrin mRNA ratio (PNR) as a podocyte stress biomarker.
- Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease.
- mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.
- COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.
- Contrast-enhanced diagnostic ultrasound causes renal tissue damage in a porcine model.
- NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus.
- In vivo gas body efficacy for glomerular capillary hemorrhage induced by diagnostic ultrasound in rats.
- Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)).
- Urine podocyte mRNAs mark progression of renal disease.
- Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3.
- Simulation of diagnostic ultrasound image pulse sequences in cavitation bioeffects research.
- Doppler mode pulse sequences mitigate glomerular capillary hemorrhage in contrast-aided diagnostic ultrasound of rat kidney.
- Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
- Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet.
- Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene.
- Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention...
- Feasibility of applying ultrasound strain imaging to detect renal transplant chronic allograft nephropathy.
- Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-...
- Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin.
- Podocyte-specific expression of cre recombinase in transgenic mice.
- Lack of correlation between facility-based standardized rates of transplantation and mortality.
- Two gene fragments that direct podocyte-specific expression in transgenic mice.
- Naturally occurring disseminated group B streptococcus infections in postnatal rats.
- Lipid microvesicles and their association with procoagulant activity in urine and glomeruli of rabbits with nephrotoxic nephritis.
- Constant intrarenal infusion of PGE1 into a canine renal transplant using a totally implantable pump.
- Myelination: a critical stage in development.
- A large outbreak of cryptosporidiosis associated with a public water supply from a deep chalk borehole. Outbreak Investigation Team.
- Kinin release from high molecular weight kininogen by the action of Hageman factor in the absence of kallikrein.
- Differentiation-specific demethylation of myelin associated glycoprotein gene in cultured oligodendrocytes.
- Hydrogen peroxide induces rapid digestion of oligodendrocyte chromatin into high molecular weight fragments.
- Prolonged daily inhalation of halothane modifies the dose-response pattern to acute administration of halothane. An electrophysiological study.
- Cryptosporidium meleagridis from humans: molecular analysis and description of affected patients.
- Fragmentation and polymeric complexes of albumin in human urine.
- Myelin gene activation: a glucose sensitive critical period in development.
- Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee.
- A morphometric analysis of pyramidal tract structures during postnatal undernourishment and recovery.
- Comparative ability of human monocytes and neutrophils to degrade glomerular basement membrane in vitro.
- Tumor necrosis factor production and accumulation of inflammatory cells in the corpus luteum of pseudopregnancy and pregnancy in rabbits.
- Procoagulant activity in glomeruli and urine of rabbits with nephrotoxic nephritis.
- Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells.
- Procoagulant activity in normal human urine associated with subcellular particles.
- Demonstration by iodine-131-hippurate renography of a marked sensitivity of some transplanted kidneys to volume contraction.
- Tumor necrosis factor-a (TNF-a) production and localization of macrophages and T lymphocytes in the rabbit corpus luteum.
- Urine transforming growth factor-beta activity is related to the degree of scarring in crescentic nephritis in the rabbit.
- Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit.
- Glomerular basement membrane-containing immune complexes stimulate tumor necrosis factor and interleukin-1 production by human monocytes.
- Procoagulant activity in kidneys of normal and bacterial lipopolysaccharide-treated rabbits.
- Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.
- Fibronectin is the major fibroblast chemoattractant in rabbit anti-glomerular basement membrane disease.
- Consequences of glomerular injury. Glomerular crescent formation.
- Evidence for the role of oxygen radicals in acute nephrotoxic nephritis.
- Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells.
- Assignment of the human podocalyxin-like protein (PODXL) gene to 7q32-q33.
- Tissue factor expression in endothelial cell/monocyte cocultures stimulated by lipopolysaccharide and/or aggregated IgG. Mechanisms of cell:cell communication.
- Tissue factor production by cultured rat mesangial cells. Stimulation by TNF alpha and lipopolysaccharide.
- In vitro and in vivo interleukin-8 production in human renal cortical epithelia.
- Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders.
- Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
- Analysis of T cells and major histocompatibility complex class I and class II mRNA and protein content and distribution in antiglomerular basement membrane disease in ...
- Analysis of renal fibrosis in a rabbit model of crescentic nephritis.
- The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.
- Amount of antibody is critical for immune complex displacement by charge competition from both rabbit glomeruli and anionic beads.
- Glomerular injury and proteinuria in rats after intrarenal injection of cobra venom factor. Evidence for the role of neutrophil-derived oxygen free radicals.
- Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin.
- Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury.
- The spectrum of podocytopathies: a unifying view of glomerular diseases.
- No evidence for genotype/phenotype correlation in NPHS1 and NPHS2 mutations.
- Renal biopsy collagen I mRNA predicts scarring in rabbit anti-GBM disease: comparison with conventional measures.
- Moderate protection of renal function and reduction of fibrosis by colchicine in a model of anti-GBM disease in the rabbit.
- Molecular cloning, expression, and distribution of glomerular epithelial protein 1 in developing mouse kidney.
- Vascular adventitial cell expression of collagen I messenger ribonucleic acid in anti-glomerular basement membrane antibody-induced crescentic nephritis in the rabbit....
- Fibronectin mRNA and protein accumulation, distribution, and breakdown in rabbit anti-glomerular basement membrane disease.
- Analysis of alpha 1 (I) procollagen alpha 1 (IV) collagen, and beta-actin mRNA in glomerulus and cortex of rabbits with experimental anti-glomerular basement membrane ...
- Elasticity imaging for early detection of renal pathology.
- Glomerular epithelial protein 1 and podocalyxin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man.
- Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferenti...
- Reconstructive ultrasound elasticity imaging for renal transplant diagnosis: kidney ex vivo results.
- Fibronectin mRNA in the developing glomerular crescent in rabbit antiglomerular basement membrane disease.
- GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury.
- Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assi...
- Evaluation of quantitative magnetic resonance imaging as a noninvasive technique for measuring renal scarring in a rabbit model of antiglomerular basement membrane dis...
- Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium.
- GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit.
- The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.
- Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat.
- Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate.
- Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis.
- Nephron injury induced by diagnostic ultrasound imaging at high mechanical index with gas body contrast agent.
- An in vivo rat model simulating imaging of human kidney by diagnostic ultrasound with gas-body contrast agent.
- Glomerular capillary hemorrhage induced in rats by diagnostic ultrasound with gas-body contrast agent produces intratubular obstruction.
- Frequency dependence of kidney injury induced by contrast-aided diagnostic ultrasound in rats.
- Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS).
Doctors Specialties
- Internal Medicine
- Nephrology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Hospital
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University of Michigan Hospitals and Health Centers
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