Professor, Pediatrics, Emory Univ Sch of Med
Pediatric Endocrinology
Dr. Saul J. Karpen, MD
|
|
Give Review
Saul Karpen practices Pediatric Endocrinology. He researched medicine at Icahn School of Medicine at Mount Sinai. Icahn School of Medicine at Mount Sinai is ranked 20/62 in Research/PrimaryCare. He received 2 awards: "Super Doctor" and "Top MD". Saul Karpen is a published doctor and has 101 publications published. The lastest was: 'A 5-year-old boy with hepatomegaly and linear growth delay.'
Publications
- Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.
- Inflammation-associated upregulation of the sulfated steroid transporter Slc10a6 in mouse liver and macrophage cell lines.
- Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatoHepatitis.
- P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in Response to partial hepatectomy.
- Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with Biliary atresia.
- Not all (bile acids) who wander are lost: The 1(st) report of a patient with an isolated NTCP defect.
- Medical Status of 219 Children with Biliary Atresia Surviving Long-Term with Their Native Livers: Results from a North American Multicenter Consortium.
- Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with Biliary atresia: the START randomized clinical trial.
- GastroIntestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis.
- Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver Disease.
- Impaired bile acid handling and aggravated liver injury in mice expressing a hepatocyte-specific RXRα variant lacking the DNA-Binding Domain.
- Inflammatory Mediators Increase SUMOylation of Retinoid X Receptor α in a c-Jun N-Terminal Kinase-Dependent Manner in Human Hepatocellular Carcinoma Cells.
- Do Therapeutic Bile Acids Hit the Sweet Spot of Glucose Metabolism in NAFLD?
- Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial.
- Increasing prevalence of nonalcoholic fatty liver Disease among United States adolescents, 1988-1994 to 2007-2010.
- Liver transplantation in cystic fibrosis: A report from Baylor College of Medicine and the Texas Children's Hospital.
- Discordant Presentation of Biliary Atresia In Premature Monozygotic Twins.
- Patients with Biliary atresia have elevated direct/conjugated bilirubin levels shortly after birth.
- Gene-specific alterations of hepatic gene expression by ligand activation or hepatocyte-selective inhibition of retinoid X receptor-? signalling during inflammation.
- Cardiac Structural and Functional Alterations in Infants and Children With Biliary Atresia, Listed for Liver Transplantation.
- Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies.
- Language and motor skills are impaired in infants with Biliary atresia before transplantation.
- Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of Biliary fibrosis.
- The role of inflammation in cholestasis: clinical and basic aspects.
- Growing old gracefully: caring for the 90-year-old liver in the 40-year-old transplant recipient.
- Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin.
- Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.
- Liver tumors: pediatric population.
- Improving the lives of adults with liver Disease by focusing on children.
- Analysis of recent pediatric orthotopic liver transplantation outcomes indicates that allograft type is no longer a predictor of survivals.
- Liver ischemia and ischemia-reperfusion induces and trafficks the multi-specific metal transporter Atp7b to bile duct canaliculi: possible preferential transport of ir...
- Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein.
- Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR.
- Intestinal failure-associated liver disease: management and treatment strategies past, present, and future.
- Isolated orthotopic liver transplantation for parenteral nutrition-associated liver injury.
- Resolution of medically resistant hypothyroidism after liver transplantation for hepatic hemangioendothelioma.
- The natural history of Hepatitis C virus in pediatric liver transplant recipients.
- Impact of pretransplant growth retardation in pediatric liver transplantation.
- Nuclear export of retinoid X receptor alpha in Response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.
- The pediatric end-stage liver Disease (PELD) model as a predictor of survival benefit and posttransplant survival in pediatric liver transplant recipients.
- Risk stratification of adult patients undergoing orthotopic liver transplantation for fulminant hepatic failure.
- Combined lung and liver transplantation: the United States experience.
- Orthotopic liver transplantation for Biliary atresia: the U.S. experience.
- Exercising the nuclear option to treat cholestasis: CAR and PXR ligands.
- Neonatal hemochromatosis: radiographical and histological signs.
- Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation.
- Valganciclovir for the prophylaxis of cytomegalovirus Disease in pediatric liver transplant recipients.
- Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes.
- Itchin' for a diversion.
- Intravenous Cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient.
- Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent.
- Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium.
- Tyrosinemia.
- Update on the etiologies and management of neonatal cholestasis.
- Identification of protein-binding sites in the Hepatitis B virus enhancer and core promoter domains.
- Tumor necrosis factor-alpha induces a kappa B sequence-specific DNA-binding protein in human hepatoblastoma HepG2 cells.
- Selective inhibition of Hepatitis B virus and human immunodeficiency virus sequence-promoted gene expression by cotransfected poly(I):poly(C).
- HNF-1 alpha: have bile acid transport genes found their "master"?
- Diet and disease: the "phyte" over Intestinal cholesterol.
- New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor.
- The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp.
- TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding.
- Bile acids regulate their own synthesis: the nuclear connection.
- Divergent homeobox gene hex regulates promoter of the Na(+)-dependent bile acid cotransporter.
- HNF3beta and GATA-4 transactivate the liver-enriched homeobox gene, Hex.
- Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation.
- Endotoxin-stimulated macrophages decrease bile acid uptake in WIF-B cells, a rat hepatoma hybrid cell line.
- Bile acids go nuclear!
- Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane.
- Genetic mutations causing hereditary cholestasis.
- A 5-year-old boy with hepatomegaly and linear growth delay.
- Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.
- Enhanced Na+-dependent bile salt uptake by WIF-B cells, a rat hepatoma hybrid cell line, following growth in the presence of a physiological bile salt.
- Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5.
- Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter.
- Acute pancreatitis associated with acute Hepatitis A in a young child.
- Assignment of a rat liver Na+/bile acid cotransporter gene to chromosome 6q24.
- Nuclear receptor regulation of hepatic function.
- HepatoBiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride.
- Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1.
- Vaccinations for adult solid-organ transplant recipients: current recommendations and protocols.
- Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat.
- Asymptomatic small bowel intussusception associated with post-transplant lymphoproliferative Disease.
- Calcium is good for the nucleus.
- Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer.
- Adult liver transplant candidate attitudes toward graft sharing are not obstacles to split liver transplantation.
- Split-liver transplantation using the left lateral segment: a collaborative sharing experience between two distant centers.
- Intrahepatic cholestasis: summary of an American Association for the Study of Liver Diseases single-topic conference.
- Liver transplantation for severe hepatic graft-versus-host Disease: an analysis of aggregate survival data.
- Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats.
- Treatment of acute tacrolimus whole-blood elevation with phenobarbital in the pediatric liver transplant recipient.
- Developmental outcomes with early orthotopic liver transplantation for infants with neonatal-onset urea cycle defects and a female patient with late-onset ornithine tr...
- Gastroschisis and Biliary atresia in a neonate: uncommon presentation or common precipitant.
- Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
- Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative Disease following pediatric liver transplantation.
- Hepatitis C viral recurrence in a pediatric patient following liver transplantation.
- Evaluation and management of patients with propionic acidemia undergoing liver transplantation: a comprehensive review.
- Cellular and molecular biology of the liver.
- Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver.
- Growth failure and outcomes in infants with Biliary atresia: a report from the Biliary Atresia Research Consortium.
Schools
MT SINAI SCH OF MED OF NY UNIV
Yale New Haven Hospital
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Biliary Atresia
- Diverticulosis, Intestinal
- Gastroesophageal Reflux Disease (GERD)
- View All
Doctors Specialties
- Pediatric Gastroenterology
- Pediatric Transplant Hepatology
- Pediatric Endocrinology
Accepted Insurances
Awards
- Super Doctor
- Top MD
Education
-
Yale-New Haven Hospital -
Icahn School of Medicine at Mount Sinai
Hospital
-
Children's Healthcare of Atlanta
Helpful Reviews
Similar Doctors
|
|
Dr. Joey C. Low, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rene Romero, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Gayathri J. Tenjarla, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Lillian R. Meacham, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Cary G. Sauer, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Jee-Young N. Ham, MD |
|
|
Dr. Andrew B. Muir, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Conrad R. Cole, MD |
|
|
Dr. Michael V. Mendoza, MD |
|
|
Dr. Leonidas Panagiotakopoulos, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Ellen Ferrari, CPNP
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Dellys M. Soler, MD
This Doctor is OpenDoctor Recommended.
|