Physician
Oncology
Dr. Stephen B. Gruber, MD
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Stephen B. Gruber is an expert in the field of Oncology. He graduated from Perelman School of Medicine at the University of Pennsylvania. He received 4 awards: "America's Top Doctors", "Top Doctors:LA Area", "America's Top Doctors for Cancer" and "Elected Member". Stephen Gruber is a published doctor as well. He has 101 publications published. The latest was: Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Publications
- Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways.
- A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid Cancer.
- Increased yield of actionable mutations using multi-gene panels to assess hereditary Cancer susceptibility in an ethnically diverse clinical cohort.
- A genome-wide association study for colorectal Cancer identifies a risk locus in 14q23.1.
- Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
- Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study.
- Abnormal high-energy phosphate molecule metabolism during regional Brain activation in patients with bipolar disorder.
- MicroRNA polymorphisms and risk of colorectal Cancer.
- Hereditary colorectal Cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal Cancer: European ...
- Sun Exposure and Melanoma Survival: A GEM Study.
- Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study.
- Screening for Germline Mismatch Repair Mutations Following Diagnosis of Sebaceous Neoplasm.
- A novel colorectal Cancer risk locus at 4q32.2 identified from an international genome-wide association study.
- The impact of exposure-biased sampling designs on detection of gene-environment interactions in case-control studies with potential exposure misclassification.
- Large-scale genetic study in East Asians identifies six new loci associated with colorectal Cancer risk.
- MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors.
- The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3).
- Cumulative Exposure to Medical Radiation for Children Requiring Surgery for Congenital Heart Disease.
- Tumor-Infiltrating Lymphocyte Grade in Primary Melanomas Is Independently Associated With Melanoma-Specific Survival in the Population-Based Genes, Environment and Mel...
- Interaction of Fatty Acid Genotype and Diet on Changes in Colonic Fatty Acids in a Mediterranean Diet Intervention Study.
- Distinct molecular features of colorectal Cancer in Ghana.
- Adrenocortical carcinoma is a lynch syndrome-associated Cancer.
- An oncocytic adRenal tumour in a patient with Birt-Hogg-Dubé syndrome.
- Transcriptome Profiling Identifies HMGA2 as a Novel Gene in Melanoma Progression and Prognosis.
- Contemporary outcomes of surgical ventricular septal defect closure.
- Elevated Risk of Prostate Cancer Among Men With Lynch Syndrome.
- BAYESIAN SEMIPARAMETRIC ANALYSIS FOR TWO-PHASE STUDIES OF GENE-ENVIRONMENT INTERACTION.
- Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis.
- Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma.
- Inflammatory bowel disease and familial adenomatous polyposis.
- Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons.
- A pilot study of microsatellite instability and endometrial Cancer survival in white and African American women.
- Mukherjee et al. Respond to "GE-Whiz! Ratcheting Up Gene-Environment Studies"
- Familial renal Cancer as an indicator of hereditary leiomyomatosis and renal cell Cancer syndrome.
- Personalized oncology through integrative high-throughput sequencing: a pilot study.
- Micromanaging the classification of colon Cancer. The role of the microRNAome.
- Gene Expression Differences Between Colon and Rectum Tumors.
- Interaction of CDKN2A and Sun Exposure in the Etiology of Melanoma in the General Population.
- Meta-analysis of new genome-wide association studies of colorectal Cancer risk.
- An American founder mutation in MLH1.
- Higher Micronutrient Intake Is Associated With Human Papillomavirus-Positive Head and Neck Cancer: A Case-Only Analysis.
- Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome.
- Risk of colorectal Cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use.
- AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome.
- MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal Cancers.
- Use of bisphosphonates and reduced risk of colorectal Cancer.
- High Risk of Colorectal and Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation.
- Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers.
- Clinical implications of UGT1A1*28 genotype testing in colorectal Cancer patients.
- Nonsteroidal anti-inflammatory drugs and risk of melanoma.
- Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population.
- Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paraganGliomas.
- A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome.
- MLH1 founder mutations with moderate penetrance in Spanish Lynch syndrome families.
- Returning individual research results: development of a Cancer genetics education and risk communication protocol.
- Case-control studies of gene-environment interaction: Bayesian design and analysis.
- Allele-specific expression of APC in adenomatous polyposis families.
- Prevalence and predictors of appropriate colorectal Cancer surveillance in Lynch syndrome.
- Missing Exposure Data in Stereotype Regression Model: Application to Matched Case-Control Study with Disease Subclassification.
- Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal Cancer.
- A case-control study of levothyroxine and the risk of colorectal Cancer.
- Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal Cancer.
- Common variation in ISL1 confers genetic susceptibility for human congenital heart disease.
- Calculation of risk of colorectal and endometrial Cancer among patients with Lynch syndrome.
- Risk of pancreatic Cancer in families with Lynch syndrome.
- Use of hormone replacement therapy and the risk of colorectal Cancer.
- Colorectal Cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome.
- Emerging molecular technologies for identifying the risk of second Cancers.
- Pediatric duodenal Cancer and biallelic mismatch repair gene mutations.
- Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis.
- Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation.
- Pretreatment health behaviors predict survival among patients with head and neck squamous cell carcinoma.
- Gene expression patterns in mismatch repair-deficient colorectal Cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AK...
- FOXP3 germline polymorphisms are not associated with risk of breast Cancer.
- Anticipation in lynch syndrome: still waiting for the answer.
- Pathologic predictors of microsatellite instability in colorectal Cancer.
- Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal Cancer risk.
- Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs.
- Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal Cancer.
- PTPRJ haplotypes and colorectal Cancer risk.
- Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation.
- Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and Renal c...
- Quality of life scores predict survival among patients with head and neck Cancer.
- Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
- FGFR2 is a breast Cancer susceptibility gene in Jewish and Arab Israeli populations.
- Genome-wide association scan identifies a colorectal Cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
- Sharing genetic test results in Lynch syndrome: communication with close and distant relatives.
- Health behaviors of head and neck Cancer patients the first year after diagnosis.
- First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome.
- Inference of the Haplotype Effect in a Matched Case-Control Study Using Unphased Genotype Data.
- Network modeling links breast Cancer susceptibility and centrosome dysfunction.
- Genetic variation in 8q24 associated with risk of colorectal Cancer.
- Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric Cancer.
- APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel.
- BRAF and NRAS mutations in spitzoid melanocytic lesions.
- Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma.
- Incidence of initial local therapy among men with lower-risk prostate Cancer in the United States.
- Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and normal left ventricle.
- Frequency and spectrum of Cancers in the Peutz-Jeghers syndrome.
- Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Schools
Perelman School of Medicine University of Pennsylvania
Johns Hopkins University School Med
University Of Pa Health System
Conditions Treated
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Cancer
- Breast Cancer
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Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:LA Area
- America's Top Doctors for Cancer
- Elected Member
Education
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Johns Hopkins University -
University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
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