Director, Herbert Irving Comprehensive Cancer Center, Clyde Wu Professor of Medicine and Immunology, Columbia University College of Physicians and Surgeons
Hematology
Dr. Stephen Emerson, MD
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Stephen Emerson works in the field of Hematology. He went to Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care He has 24 awards "Elected Member", "Chevalier of the French Legion of Honor", "Selma and Karl Folkers Lectureship Prize", "Wilbur Cross Medal", "Ocala Royal Dame Prize in Cancer Research", "Bai-Yu-Lan Prize", "Donald B. Martin Teaching Service Award", "Career Achievement Award", "Top Doc for Hematology", "Francis C. Wood Professorship", "Fellow", "Stohlman Award", "M.A. (Hon.)", "Jerome W. Conn Faculty Research Award", "Scholar Award", "Frank E. Trobaugh Young Hematology Investigator Award", "Clinical Investigator Award", "Clinical Fellowship", "Medical Scientist Trainee Prize", "Upjohn Graduate Research Fellowship", "George Pierce Chemistry Prize", "National Institutes of Health Medical Scientist Training Fellowship", "Phi Beta Kappa (Zeta of Pennsylvania)" and "National Science Foundation Student Fellowship in Mathematics". Stephen Emerson has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Ex vivo expansion of hematopoietic cells from umbilical cord blood for clinical transplantation.'
Publications
- Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
- The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs.
- Brief report: long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging.
- NF-Ya protein delivery as a tool for hematopoietic progenitor cell expansion.
- Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease.
- Graft-versus-leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing.
- Tanning before transplant: lancing the Langerhans cell.
- A new bone to pick: osteoblasts and the haematopoietic stem-cell niche.
- Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells.
- Stem cell transplantation (cord blood transplants).
- Molecular pathways regulating the self-renewal of hematopoietic stem cells.
- Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease.
- Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease.
- Hematopoietic cytokines, transcription factors and lineage commitment.
- APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease.
- NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.
- Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.
- Host-reactive CD8+ memory stem cells in graft-versus-host disease.
- Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
- c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression.
- Hematopoietic stem-cell contribution to ectopic skeletogenesis.
- Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation.
- CD4+ T cells generated de novo from donor hemopoietic stem cells mediate the evolution from acute to chronic graft-versus-host disease.
- Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cel...
- Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative d...
- Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0.
- T memory stem cells: looking for stem cells in an immune haystack.
- A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody.
- Bone and blood vessels: the hard and the soft of hematopoietic stem cell niches.
- Immune reconstitution: how it should work, what's broken, and why it matters.
- Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice.
- Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host dis...
- TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells.
- Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
- Pharmacologic eigenvalues: beating the rap on bone marrow failure.
- NF-Y is necessary for hematopoietic stem cell proliferation and survival.
- NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal.
- Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease.
- Augmented production of interleukin-6 by normal human osteoblasts in response to CD34+ hematopoietic bone marrow cells in vitro.
- Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures.
- Regulation of interleukin 3 gene induction in normal human T cells.
- A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.
- Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoies...
- Developmental regulation of erythropoiesis by hematopoietic growth factors: analysis on populations of BFU-E from bone marrow, peripheral blood, and fetal liver.
- Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating facto...
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
- ETK2 receptor tyrosine kinase promotes survival of factor-dependent FDC-P1 progenitor cells.
- The role of parathyroid hormone and insulin-like growth factors in hematopoietic niches: physiology and pharmacology.
- Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitors.
- Human osteosarcoma cell lines MG-63 and SaOS-2 produce G-CSF and GM-CSF: identification and partial characterization of cell-associated isoforms.
- Intensive graft-versus-host disease prophylaxis is required after unrelated-donor nonmyeloablative stem cell transplantation.
- Interleukin-1 alpha upregulates tumor necrosis factor receptors expressed by a human bone marrow stromal cell strain: implications for cytokine redundancy and synergy.
- CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
- Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment.
- Hybrid HIV/MSCV LTR enhances transgene expression of lentiviral vectors in human CD34(+) hematopoietic cells.
- Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells.
- The role of osteoblasts in the hematopoietic microenvironment.
- Interleukin-6 is a component of human umbilical cord serum and stimulates hematopoiesis in embryonic stem cells in vitro.
- Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics.
- Infection and replication of human cytomegalovirus in bone marrow stromal cells: effects on the production of IL-6, MIP-1alpha, and TGF-beta1.
- Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor.
- Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.
- Can Dexter cultures support stem cell proliferation?
- Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1.
- In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors.
- Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro.
- Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites.
- Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5'' cDNA sequences.
- The immunobiology of T cell therapies for leukemias.
- Answer: Marrow stem cell transplantation in fibrodysplasia ossificans progressiva.
- Bone marrow progenitor cells induce a regulatory autologous proliferative T lymphocyte response.
- Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels.
- Clinical application of hematopoietic stem cell culture and expansion.
- Abnormal myelocytic cell development in interleukin-2 (IL-2)-deficient mice: evidence for the involvement of IL-2 in myelopoiesis.
- The potential for clinical ex vivo hematopoiesis.
- Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system.
- Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice.
- Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures.
- Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells.
- Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures.
- Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin.
- The regulatory mechanisms of human immunodeficiency virus replication predict multiple expression rates.
- Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity.
- The construction of high efficiency human bone marrow tissue ex vivo.
- The influence of extra-cellular matrix and stroma remodeling on the productivity of long-term human bone marrow cultures.
- IL-1 alpha and TNF alpha act synergistically to stimulate production of myeloid colony-stimulating factors by cultured human bone marrow stromal cells and cloned strom...
- Deficient T cell granulocyte-macrophage colony stimulating factor production in allogeneic bone marrow transplant recipients.
- Decreased hematopoietic accessory cell function following bone marrow transplantation.
- Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells.
- Increased efficiency of liposome-mediated transfection by volume reduction and centrifugation.
- The regulation of hematopoiesis following bone marrow transplantation.
- A tissue of T cells.
- Synergistic regulation of human megakaryocyte development.
- In vitro expansion of hematopoietic cells for clinical application.
- Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells.
- The regulation of hematopoiesis in the human fetal liver.
- Ex vivo expansion of hematopoietic cells from umbilical cord blood for clinical transplantation.
- Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte-macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by...
- Biotinylated granulocyte/macrophage colony-stimulating factor analogues: effect of linkage chemistry on activity and binding.
- Characterization of a new human multiple myeloma cell line, UMJF-2, which suppresses antibody production by B-lymphocytes in vitro.
Schools
Yale University
Massachusetts General Hospital
Brigham Womens Hospital
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
- Freedom Plan
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
Awards
- Elected Member
- Chevalier of the French Legion of Honor
- Selma and Karl Folkers Lectureship Prize
- Wilbur Cross Medal
- Ocala Royal Dame Prize in Cancer Research
- Bai-Yu-Lan Prize
- Donald B. Martin Teaching Service Award
- Career Achievement Award
- “Top Doc†for Hematology
- Francis C. Wood Professorship
- Fellow
- Stohlman Award
- M.A. (Hon.)
- Jerome W. Conn Faculty Research Award
- Scholar Award
- Frank E. Trobaugh Young Hematology Investigator Award
- Clinical Investigator Award
- Clinical Fellowship
- Medical Scientist Trainee Prize
- Upjohn Graduate Research Fellowship
- George Pierce Chemistry Prize
- National Institutes of Health Medical Scientist Training Fellowship
- Phi Beta Kappa (Zeta of Pennsylvania)
- National Science Foundation Student Fellowship in Mathematics
Education
-
Brigham and Women's Hospital -
Boston Children's Hospital -
Massachusetts General Hospital -
Yale University -
Yale University School of Medicine
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