Physician
Pathology
Dr. Steven L. Gonias, MD
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Steven Gonias works in the field of Pathology. He went to Duke University School of Medicine. Duke University School of Medicine is a one of the best medicals schools. Duke University School of Medicine has a rank of 8 in research and a 29 in primary care Steven L. Gonias, MD is also a published MD. He has 102 publication published. The most recent publication is: Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18.
Publications
- Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
- A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.
- uPAR Induces Expression of TGF-β and Interleukin 4 in Cancer Cells to Promote Tumor-Permissive Conditioning of Macrophages.
- LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein.
- LDL Receptor-Related Protein-1: A Regulator of Inflammation in Atherosclerosis, Cancer, and Injury to the Nervous System.
- Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors.
- Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necroti...
- Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.
- The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury.
- Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.
- Regulation of the Urokinase Receptor (uPAR) by LDL Receptor-related Protein-1 (LRP1).
- Maspin: the molecular bridge between the plasminogen activator system and {beta}1 integrin that facilitates cell adhesion.
- Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1.
- LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.
- Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells.
- Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.
- Factor XII bridges coagulation and fibrinolysis again.
- Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.
- Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.
- The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice.
- Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.
- Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization.
- The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-rela...
- Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.
- Urokinase: the identity crisis continues.
- Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
- A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.
- Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis.
- High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish.
- The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.
- Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member.
- uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells.
- The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.
- Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.
- Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression.
- Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.
- The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts.
- Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase i...
- Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury.
- Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1.
- Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.
- Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro.
- Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface.
- Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion.
- Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling.
- Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism.
- Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta.
- Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor.
- Regulation of Rac1 activation by the low density lipoprotein receptor-related protein.
- The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.
- Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.
- Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.
- Diverse roles for the LDL receptor family.
- Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells.
- Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 b...
- Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth.
- A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.
- Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requ...
- Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949.
- Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-deriv...
- Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein...
- Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.
- Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an as...
- The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro.
- Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18.
- Epidermal growth factor differentially regulates low density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes.
- A modified human alpha 2-macroglobulin derivative that binds tumor necrosis factor-alpha and interleukin-1 beta with high affinity in vitro and reverses lipopolysaccha...
- Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.
- Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth ...
- Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased ...
- alpha 2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent.
- LDL receptor family-dependent and -independent pathways for the internalization and digestion of lipoprotein lipase-associated beta-VLDL by rat vascular smooth muscle ...
- Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity.
- Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor syste...
- Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture.
- Proteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin.
- Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by ti...
- Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible m...
- Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular ...
- Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation.
- Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-beta(1) in the RAW 264.7 macrophage-like cell line.
- Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
- Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for ...
- Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat.
- Nerve growth factor-gamma activates soluble and receptor-bound single chain urokinase-type plasminogen activator.
- Binding of anisoylated Lys-plasminogen streptokinase activator complex to cells in culture.
- Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells.
- Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells.
- Platelet activation during coronary angioplasty in humans.
- Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of th...
- Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface.
- Plasminogen activator inhibitor-1 in the cerebrospinal fluid as an index of neurological disease.
- Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.
- Life-long bleeding diathesis: effect of orthotopic liver transplantation.
- Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response.
- Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and...
- Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.
- Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma.
- Reaction of nerve growth factor gamma and 7S nerve growth factor complex with human and murine alpha 2-macroglobulin.
- Characterization of the antiplasmin activity of human thrombospondin-1 in solution.
- LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response.
Schools
Duke University
Duke University Hospital
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
- Blue Card PPO
- Great West Healthcare-Cigna PPO
- First Health (Coventry Health Care) PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
-
Duke University Hospital -
Duke University School of Medicine
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