Physician
Infectious Disease
Dr. Steven M. Holland, MD
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Steven Holland is an expert in the field of Infectious Disease. He went to medical school at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care He received 1 awards: "Elected Member". Steven Holland is a published physician. He published 99 publications, including: 'Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.'
Publications
- Gastrointestinal Features of Chronic Granulomatous Disease Found During Endoscopy.
- Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomat...
- New Real-Time PCR Assays for Detection of Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Group.
- Clonal Diversification and Changes in Lipid Traits and Colony Morphology in Mycobacterium abscessus Clinical Isolates.
- Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
- Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficienc...
- Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
- Subgingival microbial communities in leukocyte adhesion deficiency and their relationship with local immunopathology.
- Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations.
- Matched Related and Unrelated Donor Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency.
- Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation for GATA2 Deficiency.
- Nocardia-induced GM-CSF is neutralized by autoantibodies in disseminated/extrapulmonary nocardiosis.
- GATA2 deficiency.
- The First US Domestic Report of Disseminated Mycobacterium avium Complex and Anti-Interferon-γ Autoantibodies.
- An AAVS1-targeted Minigene Platform for Correction of iPSCs from All Five Types of Chronic Granulomatous Disease.
- GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia.
- A woman with warts, leg swelling, and deafness.
- Assessment of Atherosclerosis in Chronic Granulomatous Disease.
- Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
- Activated STING in a Vascular and Pulmonary Syndrome.
- Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.
- Impaired cytokine responses in patients with Cryopyrin-Associated Periodic Syndrome (CAPS).
- Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss.
- A mouse model of HIES reveals pro and anti-inflammatory functions of STAT3.
- Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome.
- Generalized verrucosis in a patient with GATA2 deficiency.
- A familial syndrome of pulmonary nontuberculous mycobacteria infections.
- The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.
- GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity.
- Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.
- New Rapid Scheme for Distinguishing the Subspecies of the Mycobacterium abscessus Group and Identifying Mycobacterium massiliense Isolates with Inducible Clarithromyci...
- MonoMAC Syndrome in a Patient With a GATA2 Mutation: Case Report and Review of the Literature.
- The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases.
- Neurobehavioral Profiles in Individuals with Hyperimmunoglobulin E Syndrome (HIES) and Brain White Matter Hyperintensities.
- B-cell activating factor (BAFF) is elevated in Chronic Granulomatous Disease.
- B-cell lymphoma in a patient with complete interferon gamma receptor 1 deficiency.
- The use of 14C-FIAU to predict bacterial thymidine kinase presence: implications for radiolabeled FIAU bacterial imaging.
- Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
- The role of surgery in the management of patients with refractory chronic granulomatous disease colitis.
- Molecular Identification of Bacterial DNA in the Chorioretinal Scars of Chronic Granulomatous Disease.
- Recurrent Burkholderia gladioli Suppurative Lymphadenitis associated with Neutralizing Anti-IL-12p70 Autoantibodies.
- Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm?
- Lung Parenchyma Surgery in Autosomal Dominant Hyper-IgE Syndrome.
- Abnormal Nasal Nitric Oxide Production, Ciliary Beat Frequency and TLR Response in Pulmonary NTM Disease Epithelium.
- Interferon Alpha Treatment of Patients with Impaired Interferon Gamma Signaling.
- Clinical and therapeutic features of pulmonary nontuberculous mycobacterial disease, Brazil, 1993-2011.
- Anti-GM-CSF Autoantibodies in Patients with Cryptococcal Meningitis.
- Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.
- GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome.
- Chronic granulomatous disease.
- Diabetes, Renal and Cardiovascular Disease in p47( phox-/-) Chronic Granulomatous Disease.
- Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.
- JAKs and STATs in immunity, immunodeficiency, and cancer.
- Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset.
- Invasive fungal infection in chronic granulomatous disease: insights into pathogenesis and management.
- Hospitalizations associated with disseminated coccidioidomycosis, Arizona and California, USA.
- A novel internalization motif regulates human IFN-γ R1 endocytosis.
- Streptococcal infections in patients with chronic granulomatous disease: case report and review of the literature.
- Serologic Reactivity to the Emerging Pathogen Granulibacter bethesdensis.
- Spatial Clusters of Nontuberculous Mycobacterial Lung Disease in the United States.
- Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions.
- Lung Manifestations in an Autopsy Series of Pulmonary or Disseminated Nontuberculous Mycobacterial Disease.
- Innate immunity against Granulibacter bethesdensis, an emerging Gram-negative bacterial pathogen.
- Genotype, phenotype, and clinical course in five patients with pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome.
- Corticosteroid therapy for liver abscess in chronic granulomatous disease.
- Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
- Determination of Human Anticytokine Autoantibody Profiles Using a Particle-Based Approach.
- Hematologically important mutations: leukocyte adhesion deficiency (first update).
- A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
- Cutaneous Manifestations of DOCK8 Deficiency Syndrome.
- Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome.
- Recent Insights into the Pathobiology of Innate Immune Deficiencies.
- Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency.
- GI involvement in disseminated Mycobacterium genavense: endoscopy and histology.
- Two cases illustrating successful adjunctive interferon-γ immunotherapy in refractory disseminated coccidioidomycosis.
- Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.
- Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications.
- Chronic granulomatous disease: Overview and hematopoietic stem cell transplantation.
- Coronary Artery Abnormalities in Hyper-IgE Syndrome.
- Paucity of genotype-phenotype correlations in STAT3 mutation positive Hyper IgE Syndrome (HIES).
- Corticosteroids in the treatment of severe nocardia pneumonia in chronic granulomatous disease.
- Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit.
- Geosmithia argillacea: an emerging cause of invasive mycosis in human chronic granulomatous disease.
- Interleukin-12 receptor ?1 deficiency predisposing to disseminated Coccidioidomycosis.
- Human leukocytes kill Aspergillus nidulans by reactive oxygen species-independent mechanisms.
- Acupuncture for symptom management in patients with hyper-IgE (Job's) syndrome.
- High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease.
- Residual NADPH oxidase and survival in chronic granulomatous disease.
- Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis.
- Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia.
- Anticytokine autoantibodies in infectious diseases: pathogenesis and mechanisms.
- Immunodeficiency secondary to anticytokine autoantibodies.
- Highly variable clinical phenotypes of hypomorphic RAG1 mutations.
- Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries.
- Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.
- Hematologically important mutations: X-linked chronic granulomatous disease (third update).
- Trends and burden of bronchiectasis-associated hospitalizations in the United States, 1993-2006.
- Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
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