Associate Professor of Medicine Director, Physician Scientist Training Program University of Michigan
Nephrology
Dr. Subramaniam Pennathur, MD
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Subramaniam Pennathur is an expert in the field of Nephrology. He researched medicine at Tirunelveli Medical College. Subramaniam Pennathur is also published. He has 85 publications published. The lastest publication: "Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human athe...'
Publications
- Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host Disease.
- Oxidative Modifications of Protein Tyrosyl Residues are Increased in Plasma of Human Subjects with Interstitial Lung Disease.
- Altered Metabolic Profile With Sodium-Restricted Dietary Approaches to Stop Hypertension Diet in Hypertensive Heart Failure With Preserved Ejection Fraction.
- Impact of gestational bisphenol a on oxidative stress and free Fatty acids: human association and interspecies animal testing studies.
- Metabolomics and Diabetes: Analytical and Computational Approaches.
- Antioxidants complement the requirement for protein chaperone function to maintain beta cell function and glucose homeostasis.
- Disruption of heme-peptide covalent cross-linking in mammalian peroxidases by hypochlorous acid.
- Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry Disease.
- Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: An additional proatherogenic mechanism in systemic lupus erythematosus.
- Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis.
- mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes.
- Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
- The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion.
- Autophagy Deficiency by Hepatic FIP200 Deletion Uncouples Steatosis From Liver Injury in NAFLD.
- Long-chain acyl coenzyme A synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysf...
- How to find a prognostic biomarker for progressive diabetic nephropathy.
- Myeloperoxidase acts as a source of free iron during steady state catalysis by a feedback inhibitory pathway.
- Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion.
- Acyl-CoA Synthetase 1 is Induced by Gram-Negative Bacteria and Lipopolysaccharide and is Required for Phospholipid Turnover in Stimulated Macrophages.
- Endothelial Acyl-CoA Synthetase 1 Is Not Required for Inflammatory and Apoptotic Effects of a Saturated Fatty Acid-Rich Environment.
- High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis.
- Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes.
- Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis.
- Metabolic Signature of CKD: The Search Continues.
- Perspectives on systems biology applications in diabetic Kidney disease.
- Marking Renal injury: can we move beyond serum creatinine?
- Kinetic Studies on the Reaction between Dicyanocobinamide and Hypochlorous Acid.
- A Tripeptide Diapin Effectively Lowers Blood Glucose Levels in Male Type 2 Diabetes Mice by Increasing Blood Levels of Insulin and GLP-1.
- Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.
- Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus ...
- Localization of promoter sequences required for thyrotropin-releasing hormone and thyroid hormone responsiveness of the glycoprotein hormone alpha-gene in primary cult...
- Recombinant subunit vaccines as an approach to study correlates of protection against primate lentivirus infection.
- SA85-1 proteins of Trypanosoma cruzi lack sialidase activity.
- NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation.
- A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular Disease.
- p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima.
- Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice...
- Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human athe...
- Myeloperoxidase Targets Apolipoprotein A-I, the Major HDL Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions.
- The reaction of HOCl and cyanocobalamin: Corrin destruction and the liberation of cyanogen chloride.
- Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory Diseases.
- Urine glycoprotein profile reveals novel markers for chronic Kidney disease.
- Dose-dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor.
- Metabolomic profiling reveals a role for androgen in activating amino Acid Metabolism and methylation in prostate cancer cells.
- Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
- Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice.
- Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release.
- Mechanism of hypochlorous acid-mediated heme destruction and free iron release.
- Quantitative analysis of amino Acid oxidation markers by tandem mass spectrometry.
- Long-chain acyl-CoA synthetase 4 modulates prostaglandin E? release from human arterial smooth muscle cells.
- Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in Hypertension.
- Analytical approaches to metabolomics and applications to systems biology.
- Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and ident...
- Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid.
- Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.
- The management of diabetic neuropathy in CKD.
- NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.
- Decreased nitric oxide bioavailability in a mouse model of Fabry Disease.
- The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and Renal inflammation in murine lupus.
- Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1.
- Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
- Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus.
- Enrichment of glycoproteins using nanoscale chelating concanavalin A monolithic capillary chromatography.
- Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
- CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
- Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet.
- Antioxidants reduce endoplasmic reticulum stress and improve protein secretion.
- Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
- Combined statin and niacin therapy remodels the high-density lipoprotein proteome.
- Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage.
- Rosiglitazone reduces Renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy.
- Rosiglitazone treatment reduces diabetic neuropathy in streptozotocin-treated DBA/2J mice.
- Oxidative stress and endothelial dysfunction in vascular Disease.
- Mechanisms for oxidative stress in diabetic cardiovascular Disease.
- Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL.
- Detection of chronic Kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney And ...
- Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids.
- Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.
- Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson''s Disease in mice.
- Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes.
- Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL.
- The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport.
- Human atherosclerotic intima and blood of patients with established coronary artery Disease contain high density lipoprotein damaged by reactive nitrogen species.
- Mechanisms of oxidative stress in diabetes: implications for the pathogenesis of vascular Disease and antioxidant therapy.
Schools
Tirunelveli Medical College Tamil Nadu Dr Mgr Medical University
Barnes Jewish Hospital
Procedures Preformed
- Hemodialysis
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Chronic Kidney Diseases
- End-Stage Renal Disease
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Doctors Specialties
- Nephrology
Accepted Insurances
Education
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Washington University -
Washington University - Barnes-Jewish Hospital -
Tirunelveli Medical College
Hospital
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University of Michigan Hospitals and Health Centers
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