Lecturer, Pediatrics, Tufts Medical Center
Hematology
Dr. Susan P. Perrine, MD
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Susan Perrine practices Hematology. She researched medicine at Tufts University School of Medicine. Tufts University School of Medicine is ranked 49 in research and 52 in primary care medicine She over the years received 2 awards: "Regional Top Doctor" and "Elected Member". Susan Perrine is a published doctor and has 75 publications published. The lastest was: 'Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells.'
Publications
- Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies.
- Stressing HbF synthesis: role of translation?
- Butyrate histone deacetylase inhibitors.
- Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize Lymphoma cells to nucleoside anti-viral agents.
- Switching globin, raising red Cells.
- Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
- Short-term Toxicity Study of ST-20 (NSC-741804) by Oral Gavage in Sprague-Dawley Rats.
- Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Si...
- Fetal globin gene inducers: novel agents and new potential.
- Effects of divalproex sodium on hemoglobin level.
- Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
- A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid Malignancies.
- Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected Lymphoma cells to nucleoside analogue antiviral agents.
- Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.
- Novel short chain fatty acids restore chloride secretion in cystic fibrosis.
- Fas ligand-mediated lethal hepatitis after rapid lysis of a localized natural killer cell Lymphoma.
- Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives.
- Fetal globin induction--can it cure beta Thalassemia?
- Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.
- Sickle cell Anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels.
- Biochemical effect of intravenous arginine butyrate in X-linked adrenoleukodystrophy.
- Alpha-lipoic acid induces p27Kip-dependent Cell cycle arrest in non-transformed Cell lines and apoptosis in tumor Cell lines.
- Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.
- Natural history of sickle cell Anemia in Saudi Arabs. A study of 270 subjects.
- Sickle cell Disease in Saudi Arabs in early childhood.
- The role of homeobox genes in erythropoiesis.
- Sequence of the -530 region of the beta-globin gene of sickle cell Anemia patients with the Arabian haplotype.
- Recombinant human GM-CSF treatment of neutropenia in glycogen storage Disease-1b.
- Inhibition of fetal globin gene switching in vivo in human and ovine fetuses.
- Sickle cell Disease: new insights into pathophysiology and treatment.
- Butyrate increases the efficiency of translation of gamma-globin mRNA.
- Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated Malignancies.
- Epstein--Barr virus post-transplant lymphoproliferative Disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate.
- Short-chain fatty acid derivatives stimulate Cell proliferation and induce STAT-5 activation.
- Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid Cell adhesion in vitro.
- Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell Disease.
- Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial Cells.
- Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy.
- Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis.
- Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated Lymphoma.
- Abrogation of IL-3 requirements and stimulation of hematopoietic Cell proliferation in vitro and in vivo by carboxylic acids.
- Butyrate in the treatment of sickle cell Disease and beta-thalassemia.
- Erythroid progenitor proliferation is stimulated by phenoxyacetic and phenylalkyl acids.
- Butyrate-induced reactivation of the fetal globin genes: a molecular treatment for the beta-hemoglobinopathies.
- A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin Disorders.
- Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture.
- Isobutyramide, an orally bioavailable butyrate analogue, stimulates fetal globin gene expression in vitro and in vivo.
- Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin Disorders.
- The biochemistry of erythropoietin: an approach to its mode of action.
- Erythropoietin-induced differentiation of Rauscher erythroLeukemia cells.
- Chediak-Higashi syndrome: studies in long-term bone marrow culture.
- Hematopoietic hormones: from cloning to clinic.
- Butyrate analogues modulate globin gene expression in human and ovine erythroid Cells.
- Delay in the fetal globin switch in infants of diabetic mothers.
- Butyric acid modulates developmental globin gene switching in man and sheep.
- MB-02 Cells undergo fetal to adult globin gene switching in response to erythropoietin.
- Human embryonic zeta-globin chains in fetal and newborn blood.
- Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta Thalassemia.
- Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching.
- A physiological delay in human fetal hemoglobin switching is associated with specific globin DNA hypomethylation.
- Gamma-interferon alters globin gene expression in neonatal and adult erythroid Cells.
- Stopping the biologic clock for globin gene switching.
- Pharmacologic modulation of fetal globin gene expression in the perinatal period.
- Interferon-gamma modulates fetal hemoglobin synthesis in sickle cell Anemia and thalassemia.
- Trial of recombinant human erythropoietin: three patients with Thalassemia intermedia.
- Influence of steel factor on hemoglobin synthesis in sickle cell Disease.
- Butryic acid analogues augment gamma globin gene expression in neonatal erythroid progenitors.
- Insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia.
- Prednisone stimulation of erythropoiesis in leukemic children during remission.
- Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and ''PSEUDO'' receptor models.
- Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.
- Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fa...
- Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling.
- A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory Sickle cell leg ulcers.
Schools
Tufts University
Tufts New England Mc
Harvard Med School Dana Farber
Conditions Treated
- Acute Leukemia
- Adrenal Gland Cancer
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- View All
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Regional Top Doctor
- Elected Member
Education
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Boston Children's Hospital -
Tufts Medical Center -
Tufts University School of Medicine
Hospital
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Tufts Medical Center -
Boston Medical Center
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