Surgeon-in-Chief Children's Hospital Colorado

General Surgery

Timothy Crombleholme works in the field of General Surgery. He researched medicine at Tufts University School of Medicine. Tufts University School of Medicine is ranked 49 in research and 52 in primary care medicine He over the years received 2 awards: "America's Top Doctors" and "Fellow (FACS)". Timothy Crombleholme is a published doctor. He published 99 publications, including: 'Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds.'

Publications

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• Pyloric stenosis-postoperative care on a nonsurgical ward.
• Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds.
• Intraplacental Gene Therapy with Ad-IGF-1 Corrects Naturally Occurring Rabbit Model of Intrauterine Growth Restriction.
• Fetal MRI of Torsed Bronchopulmonary Sequestration with Tension Hydrothorax and Hydrops in a Twin Gestation.
• Flow patterns in the ductus arteriosus during open fetal myelomeningocele repair.
• Prenatal MRI Diagnosis of Hirschsprung's Disease at 29 Weeks' Gestational Age in a Fetus with Heterotaxy and Polysplenia Syndrome.
• Nanofiber Microenvironment Effectively Restores Angiogenic Potential of Diabetic Endothelial Cells.
• The Role of Stem Cells in Wound Angiogenesis.
• Role of adjunctive medical therapy in the fetoscopic surgical treatment of twin-twin transfusion syndrome.
• Prevalence, Spectrum, and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-twin Transfusion Syndrome: A Large, Single-center Experience.
• Giant Chorioangiomas: Perinatal Outcomes and Techniques in Fetoscopic Devascularization.
• Regenerative Wound Healing: The Role of Interleukin-10.
• Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis.
• Comparison of interleukin 10 homologs on dermal wound healing using a novel human skin ex vivo organ culture model.
• Whole exome sequencing identifies de novo mutations in GATA6 associated with congenital diaphragmatic Hernia.
• Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in vivo and the human troph...
• Recapitulation of characteristics of human placental vascular insufficiency in a novel mouse model.
• Ex utero Intrapartum Treatment to Resection of a Bronchogenic Cyst Causing Airway Compression.
• Urologic co-morbidities associated with sacrococcygeal teratoma and a rational plan for urologic surveillance.
• Developmental outcomes of children with congenital diaphragmatic Hernia: a multicenter prospective study.
• The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing.
• Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing.
• The Utility of a Composite Index for the Evaluation of Ovarian Torsion.
• The North American Fetal Therapy Network Registry Data on Outcomes of Radiofrequency Ablation for Twin-Reversed Arterial Perfusion Sequence.
• The pediatric surgeon's road to research independence: utility of mentor-based National Institutes of Health grants.
• Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications.
• Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism.
• Variants in GATA4 are a rare cause of familial and sporadic congenital diaphragmatic Hernia.
• Fetal Cervical Teratoma: What Is the Role of Fetal MRI in Predicting Pulmonary Hypoplasia?.
• Estimated cardiac output and cardiovascular profile score in fetuses with high cardiac output lesions.
• Outcomes of Congenital Diaphragmatic Hernia in the Modern Era of Management.
• Pseudotyped AAV Vector-Mediated Gene Transfer in a Human Fetal Trachea Xenograft Model: Implications for In Utero Gene Therapy for Cystic Fibrosis.
• Fetal wound healing: implications for minimal scar formation.
• Compensatory Lung Growth in NOS3 Knockout Mice Suggests Synthase Isoform Redundancy.
• The congenital diaphragmatic Hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic Hernia.
• Tissue-engineered provisional matrix as a novel approach to enhance diabetic wound healing.
• Severe cervical scoliosis in the fetus.
• Prevalence and Progression of Recipient Twin Cardiomyopathy in Early Stage Twin-Twin Transfusion Syndrome (TTTS).
• Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
• Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isola...
• Prenatal and postnatal urologic complications of sacrococcygeal teratomas.
• Fetal MRI clues to diagnose cloacal malformations.
• Fetal surgical management of congenital heart block in a hydropic fetus: lessons learned from a clinical experience.
• Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy.
• The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome.
• Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photoco...
• Characterization of endothelial progenitor cells mobilization following cutaneous wounding.
• Placental gene transfer: transgene screening in mice for trophic effects on the placenta.
• Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease.
• Ex utero intrapartum treatment procedure: a peripartum management strategy in particularly challenging cases.
• High-risk fetal congenital pulmonary airway malformations have a variable response to steroids.
• Maternal pulmonary edema during fetoscopic surgery.
• Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndrome.
• Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome.
• The outcome of twin-twin transfusion syndrome complicated with placental insufficiency.
• Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
• Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation.
• Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
• Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experience.
• A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome.
• Role of VEGF in small bowel adaptation after resection: the adaptive response is angiogenesis dependent.
• Mirror syndrome: a novel approach to therapy with fetal peritoneal-amniotic shunt.
• Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells.
• Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model.
• Regenerative properties of fetal sheep tendon are not adversely affected by transplantation into an adult environment.
• The EXIT procedure: principles, pitfalls, and progress.
• Severe pulmonary hypoplasia associated with giant cervical teratomas.
• Twin-twin transfusion syndrome: where do we go from here?
• The ex utero intrapartum therapy procedure for high-risk fetal lung lesions.
• Management of fetal mediastinal teratoma.
• Reproductive outcomes after pregnancy complicated by maternal-fetal surgery.
• Acute cardiovascular effects of fetal surgery in the human.
• Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds.
• Successful management of concommitant blunt injury to the trachea, esophagus, and cervical spine in a 6-year-old girl.
• Hybrid constructs for craniofacial reconstruction: sustained gene delivery using demineralized bone matrix putty.
• Prenatal MR findings of the middle interhemispheric variant of holoprosencephaly.
• Right congenital diaphragmatic Hernia: Prenatal assessment and outcome.
• Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome.
• Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosis.
• Regenerative versus reparative healing in tendon: a study of biomechanical and histological properties in fetal sheep.
• The treatment of twin-twin transfusion syndrome.
• Fetal myelomeningocele repair: short-term clinical outcomes.
• Congenital high airway obstruction syndrome: natural history and management.
• In utero limb salvage: fetoscopic release of amniotic bands for threatened limb amputation.
• Human fetal trachea-SCID mouse xenografts: efficacy of vesicular stomatitis virus-G pseudotyped lentiviral-mediated gene transfer.
• Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
• Fetoscopic surgery.
• Management of congenital lung lesions.
• Fetal therapy: state of the art.
• The ex-utero intrapartum treatment.
• Influence of congenital heart disease on survival in children with congenital diaphragmatic Hernia.
• Adeno-associated virus (AAV)-mediated gene transfer in respiratory epithelium and submucosal gland cells in human fetal tracheal organ culture.
• Adenovirus-mediated ex vivo gene transfer of human vascular endothelial growth factor in a rabbit laryngotracheal reconstruction model.
• Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung.
• The natural history of prenatally diagnosed conjoined twins.
• The EXIT procedure: experience and outcome in 31 cases.
• Prenatal diagnosis and treatment of intersex states.
• Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via Enhanced Placental Glucose Transport Mechanisms.

Schools

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• Tufts University School Of Medicine

• University Of California San Francisco Program

• TuftsNew England Medical Center Program

Procedures Preformed

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• Appendectomy, Laparoscopic
• Inguinal Hernia Repair, Open

Conditions Treated

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• Appendicitis
• Inguinal Hernia
• Umbilical Hernia

Doctors Specialties

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• Pediatric Surgery
• General Surgery

Accepted Insurances

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Awards

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• America's Top Doctors
• Fellow (FACS)

Education

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• Tufts Medical Center
• UCSF Medical Center
• Tufts University School of Medicine

Hospital

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• University of Colorado Hospital
• Children's Hospital Colorado

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